Computing the time-dependent activity rate using non-declustered and declustered catalogues – a first step towards time-dependent seismic hazard calculations for operational earthq... by D. Montiel-López, S. Molina, S. Molina, J. J. Galiana-Merino, J. J. Galiana-Merino, I. Gómez, I. Gómez, A. Kharazian, J. L. Soler-Llorens, J. A. Huesca-Tortosa, A. Guardiola-Villora, G. Ortuño-Sáez

“…The first one is located in Central Italy, where the L'Aquila earthquake happened, while the other is in south-eastern Spain, where several earthquakes with a moment magnitude (<span class="inline-formula"><i>M</i>_w</span>) greater than 4.0 have taken place over the last 30 years, including two earthquakes with magnitude greater than or equal to 5.0. …”
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The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…Intestinal findings indicated that TTO treatment enhanced villus height, reduced crypt depth, and upregulated the expression of Claudin 1, Occludin, and ZO-1 mRNA in the jejunum (P < 0.05). After TTO treatment, H2S-induced oxidative stress injury and apoptosis protein expression in spleen were improved (P < 0.05). …”
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Hubungan Konsumsi Makanan Fungsional Sumber Antioksidan dengan Fungsi Kognitif dan Kadar 4-Hydroxynonenal (4-HNE) Plasma Lansia by Widia Rahmawati, Nur Indrawati Lipoeto, Yuliarni Syafrit Syafrita

“…</em><em>Functional foods sources of antioxidant consumption </em><em>were </em><em>obtained </em><em>by</em><em> Foos Frequency Questionnaires and cognitive function was measured by Moca-INA method,  where as the levels of 4-HNE plasma checked in Bio</em><em>m</em><em>edic laboratory  of Unversitas Andalas.   …”
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A qualitative study exploring the acceptability of the TEXTPAD telehealth and virtual supervised exercise intervention and trial for patients with peripheral arterial disease livin... by Maddey Patterson, MPH, Letitia Sermin-Reed, MSc, James Prentis, MBBS, Arathi Radhakrishnan, MBBS, Eileen Kaner, PhD, Sandip Nandhra, MBBS, Maisie Rowland, BSc, Gabriel Cucato, PhD, Mackenzie Fong, PhD

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MLL4 regulates postnatal palate growth and midpalatal suture development by Jung-Mi Lee, Hunmin Jung, Bruno de Paula Machado Pasqua, Yungki Park, Qinghuang Tang, Shin Jeon, Shin Jeon, Soo-Kyung Lee, Jae W. Lee, Hyuk-Jae Edward Kwon

“…Whole-mount and histological staining at perinatal stages identified that the midline defects in the Mll4-cKO mice emerged as early as 1 day prior to birth, presenting as a widened midpalatal suture, accompanied by increased cell apoptosis in the suture mesenchyme. Genome-wide mRNA expression analysis of the midpalatal suture tissue revealed that MLL4 is essential for the timely expression of major cartilage development genes, such as Col2a1 and Acan, at birth. …”
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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

“…In vitro and in vivo studies demonstrated radiotracer stability in human serum (> 97% after 24 h evaluated by radio-HPLC), adequate affinity by the PDL1 protein (IC50 = 4.21 nM), and specific detection for PD-L1 assessed in 4T1, HCT116, and AR42J cancer cells, in which PD-L1 expression was verified by immunofluorescence and Western Blot assays. …”
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Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

“…Methods: The prevalence of Bbsl-specific antibodies in the English population was estimated in a cross-sectional cohort, selected from an archive of residual NHS blood donor plasma samples (age range 17 - 84, collected between 2021 - 2022). 10,000 samples were randomly selected proportionate to the population size of each of the nine English administrative regions. 9,994 samples were tested using a standard two-tiered testing strategy, with an IgG/IgM ELISA followed by an IgG immunoblot (array) test for any sera with positive or indeterminate reactivity in the ELISA. …”
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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…The addition of EDTA to Ni(II)-treated WMSS samples successfully reversed these resonance modifications, an observation confirming the transfer of Ni(II) from the above endogenous complexants to this exogenous chelator to form the highly stable diamagnetic octahedral [Ni(II)-EDTA] complex (K_stab = 1.0 × 10¹⁹ M⁻¹). <b>Conclusions:</b> The results acquired demonstrated the value of linking advanced experimental design and multivariate metabolomics/statistical analysis techniques to ¹H NMR analysis for such speciation studies. …”
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Probiotic Supplementation Alleviates Corticosterone-Induced Fatty Liver Disease by Regulating Hepatic Lipogenesis and Increasing Gut Microbiota Diversity in Broilers by Yuyan Feng, Wenqing Mei, Qu Chen, Xiaojing Chen, Yingdong Ni, Mingming Lei, Jie Liu

“…However, probiotic supplementation markedly decreased the intrahepatic lipid accumulation and steatosis histological score, which was associated with the downregulation of sterol regulatory element-binding protein-1 (<i>SREBP1</i>) and acetyl-CoA carboxylase (<i>ACC</i>) mRNA (<i>p</i> < 0.05) and the expression of its protein (<i>p</i> = 0.06). …”
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Screening semen samples for Zika virus infection: role for serologic and RT-PCR testing by Humberto Ferraz, Humberto Ferraz, Humberto Ferraz, Kevan Akrami, Kevan Akrami, Kevan Akrami, Laise de Moraes, Laise de Moraes, Lais Cambuí Gusmão, Genevieve Coelho, Daniele Freitas, Daniele Freitas, Manoel Barral-Netto, Aldina Barral, Viviane Boaventura, Viviane Boaventura, Luciane Amorim Santos, Luciane Amorim Santos, Luciane Amorim Santos, Ricardo Khouri, Ricardo Khouri

“…Human reproductive clinics typically perform serologic tests to screen for Zika infection.MethodsIn this study, we evaluated semen samples stored in a human reproduction clinic in Salvador, Brazil, during the Zika virus outbreak, using real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) technique.Results36 sperm samples from 23 donors were analyzed, including 5 with positive IgG serology for ZIKV and all negative for IgM. Despite these serologic findings, all analyzed samples were negative by RT-qPCR ZIKV.DiscussionDespite the limited number of samples, this study raises further concern that the use of serology may be an unreliable surrogate method to predict the presence of ZIKV in semen.…”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Moreover, we test the use of these piezo-activated macrophages (piezoMϕ) as adoptive cell therapy (ACT) for treating various immunosuppressive bacterial infections, including sepsis, pneumonia and peritonitis. …”
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Molecular Epidemiology, Drug-Resistant Variants, and Therapeutic Implications of Hepatitis B Virus and Hepatitis D Virus Prevalence in Nigeria: A National Study by Oludare ‘Sunbo Adewuyi, Muhammad Shakir Balogun, Hirono Otomaru, Alash’le Abimiku, Anthony Agbakizu Ahumibe, Elsie Ilori, Que Anh Luong, Nwando Mba, James Christopher Avong, John Olaide, Oyeladun Okunromade, Adama Ahmad, Afolabi Akinpelu, Chinwe Lucia Ochu, Babatunde Olajumoke, Haruka Abe, Chikwe Ihekweazu, Adetifa Ifedayo, Michiko Toizumi, Hiroyuki Moriuchi, Katsunori Yanagihara, Jide Idris, Lay-Myint Yoshida

“…Up to 33.2% (95% CI 30.0–36.6) of the participants had detectable VLs of ≥300 copies/mL. The predominant circulating HBV genotype was E with 98.4% (95% CI 97.1–99.1), followed by A with 1.6% (95% CI 0.9–2.9). …”
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A FAIR and open geographic data collection for the Massaciuccoli Lake basin wetland in ItalyZenodoZenodo by Gian Luca Vannini, Pasquale Bove, Gianpaolo Coro

“…In the GS phase, geodata were selected based on a spatial resolution compatible with regional-scale ecological models (maximum 0.0005° ≈ 50 m), and a temporal coverage that could represent from remote past to far future scenarios. …”
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Prevention and management of cytomegalovirus infection and disease in kidney transplant: A consensus statement of the Transplantation Society of Taiwan by Mu-Chi Chung, Cheng-Hsu Chen, Shen-Shin Chang, Chih-Yuan Lee, Ya-Chung Tian, Mei-Yi Wu, Hsu-Han Wang, Chia-Cheng Yu, Teng-Wei Chen, Chien-Chang Kao, Chih-Yang Hsu, Yang-Jen Chiang, Ming-Ju Wu, Yen-Ta Chen, Mai-Szu Wu

“…Routine surveillance after prophylaxis, secondary prophylaxis after CMV disease treatment, and mTOR inhibitors for primary CMV prophylaxis were not recommended. …”
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Fotobiomodulación vascular en el tratamiento de niños con transtornos temporomandibulares by María Roxana Ferreira Sertaje, Lara Motta Jansiski, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Ana Paula Taboada Sobral, Natalia Osorio Viarengo, Ana Laura Fossati, Laura Hermida, Andrea Oliver Gomes, Marcela Leticia Leal Gonçalves, Sandra Kalil Bussadori

“…El  láser que se usó es de la marca DMC Therapy Ec potencia 100 mW ±20%, longitud de onda 660nm ±10  nm, rojo, el parámetro de energía 120J, de aplicación continua. …”
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Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women by Chen Shang, Wei Sun, Chunlin Wang, Xiangqing Wang, Huijuan Zhu, Linjie Wang, Hongbo Yang, Xue Wang, Fengying Gong, Hui Pan

“…The objective of this study was to investigate the differentially expressed proteins in VAT between morbidly obese (BMI >35 kg/m2) and normal weight Chinese women. Method. Nine morbidly obese women and 8 normal weight women as controls were enrolled. …”
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Synthesis and characterization of zinc oxide nanoparticles-carbon composite derived from pineapple peel wastes for adsorption of methylene blue from solution and photocatalytic act... by Salsa Putri Alzura, Vienna Saraswaty, Safri Ishmayana, Yudha Prawira Budiman, Diana Rakhmawaty Eddy, Evyka Setya Aji, Diah Ratnaningrum, Een Sri Endah, Hanny Meirinawati, Henry Setiyanto

“…The calculated maximum adsorption capacity of the ZnONPs/PPWB composite biosorbent (qmax = 65.43 mg/g) was 1.85 folds higher compared to the non-composite biosorbent (PPWB) (qmax = 35.21 mg/g) under the following conditions; adsorbent dose of 10 mg/30 mL, pH 7, and initial MB concentration of 20 mg/L. …”
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Water and nitrogen regulation strategy for wolfberry farmland based on nitrogen balance in the Yellow River irrigation districts of Gansu Province, China by Minhua Yin, Rongrong Tian, Yi Ling, Yuqing Yang, Yanlin Ma, Yanxia Kang, Guangping Qi, Jinghai Wang

“…In contrast, the lowest level was observed under the W3N0 treatment at 90.13 kg·ha−1, which was reduced by 12.25%−51.59% compared with other treatments. (3) The soil N2O flux (28.50–433.41 ug·m−2·h−1) and total emissions (0.40–1.67 kg·ha−1) increased with increased irrigation and nitrogen application. (4) The W1N1 treatment showed the highest nitrogen productivity (14.29 kg·kg−1), absorption efficiency (0.85 kg·kg−1), and recovery efficiency (27.14%), outperformed other treatments by 0.64–10.94 kg·kg−1, 0.10−0.65 kg·kg−1, and 2.52–18.80%, respectively. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…The cytotoxic effect of 131I-HLX58-Der was observed in the CLDN18.2-positive cell line, with an IC50 of 11.28 ng/mL. In terms of cytotoxicity, 131I-HLX58-Der exhibited greater activity compared to HLX58-Der. 125I-HLX58 and 131I-HLX58-Der demonstrated similar biodistribution profiles in CLDN18.2-positive tumor models, achieving 5.72 ± 0.41%ID/g (48 h) and 5.83 ± 0.41%ID/g (72 h) in the tumor tissues postinjection, respectively. …”
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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…A GABA-producing Bacteroides finegoldii, released EVs with a high GABA content (4 µM) compared to Phocaeicola massiliensis. Upon testing the capacity of MEVs to cross host barriers, MEVs exhibited a dose-dependent paracellular transport and were endocytosed by Caco-2 and hCMEC/D3 cells. …”
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