Grotius e Rousseau: duas concepções distintas de soberania by Anderson Francisco dos Santos

Get full text

Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Results: lnc-EST885 is one of the lncRNAs with the highest expression levels in M2-type macrophages. The expression of lnc-EST885 in HCC tissues is significantly higher than in normal tissues, and high expression is associated with poor prognosis. …”
Get full text

Demographic and Dietary Determinants of the Association between Dietary Fiber Intake and Obesity in Japanese Adults with Type 2 Diabetes: A Cross-Sectional Study (JDDM 78) by Efrem d'Ávila Ferreira, Mariko Hatta, Laymon Khin, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

“…Obesity was defined as BMI ≥25 kg/m2. Setting: Clinics throughout Japan. Participants: 1,565 Japanese outpatients with type 2 diabetes (63.1% men; age range 30–89 years). …”
Get full text

Speciation Analysis of Arsenic Compounds by High-Performance Liquid Chromatography in Combination with Inductively Coupled Plasma Dynamic Reaction Cell Quadrupole Mass Spectrometry... by Hai Anh Vu, Manh Ha Nguyen, Hong-An Vu-Thi, Quan Do-Hong, Xuan Hoang Dang, Thi Ngoc Bich Nguyen, Hong Quan Trinh, Thuy Ly Bich, Tien-Thanh Nguyen, Dung Le-Van, Minh Binh Tu, Dinh Binh Chu

“…Arsenic compounds were detected online by inductively coupled plasma dynamic reaction cell quadrupole mass spectrometry utilizing oxygen as the reaction gas at a flow rate of 0.7 mL·min−1. Five selected arsenic species were baseline separated at the optimum experimental conditions. …”
Get full text

Зміни асоційованої зі здоров’ям якості життя в пацієнтів зі стабільною ішемічною хворобою серця та проміжними ураженнями вінцевих артерій після планового перкутанного коронарного в... by М. В. Стан, К. О. Міхалєв, О. Й. Жарінов, А. В. Хохлов

“…Показники асоційованої зі здоров’ям ЯЖ оцінювали за допомогою загальномедичного опитувальника SF-36 (загальний показник фізичного здоров’я – РНsum [physical health summar]; загальний показник психологічного здоров’я – MНsum [mental health summary]), а також хворобоспецифічного опитувальника SAQ (Seattle Angina Questionnaire; домени: шкала обмеження фізичних навантажень (physical limitation [PL]); шкала стабільності нападів стенокардії (angina stability [AS]); шкала частоти нападів стенокардії (angina frequency [AF]); шкала задоволеності лікуванням (treatment satisfaction [TS]); шкала ставлення до хвороби (disease perception [DP]), – початково та через 3 місяці після ПКВ. …”
Get full text

In-vivo high-resolution χ-separation at 7T by Jiye Kim, Minjun Kim, Sooyeon Ji, Kyeongseon Min, Hwihun Jeong, Hyeong-Geol Shin, Chungseok Oh, Robert J. Fox, Ken E. Sakaie, Mark J. Lowe, Se-Hong Oh, Sina Straub, Seong-Gi Kim, Jongho Lee

Get full text

Agronomic and Nutritional Evaluation of INIA 910—Kumymarca Ryegrass (<i>Lolium multiflorum</i> Lam.): An Alternative for Sustainable Forage Production in Department of Amazonas (NW... by Héctor V. Vásquez, Leandro Valqui, Leidy G. Bobadilla, Enrique Meseth, Milton J. Trigoso, Luis H. Zagaceta, Lamberto Valqui-Valqui, David Saravia-Navarro, Elgar Barboza, Jorge L. Maicelo

“…The results showed that applying 180 kg/ha of nitrogen with a 45-day cutting interval provided the highest dry matter yield (460 kg/m²) and superior agronomic traits, including plant height (96.73 cm), number of tillers, and stem diameter. …”
Get full text

Socioeconomic indicators related to the global burden of breast cancer in women in 2020: an analysis of WHO data by Tingting XU, Ruoyu YANG, Jingjing LI, Yiying FANG

“…The mean values of the 10 selected indicators representing national socioeconomic development were as follows: 2 138.06 ± 7 465.03 million for total female population, 26.58 ± 17.12 μg/m3 for mean annual urban particulate matter concentration; 63.97 ± 57.32 per 10 000 population for density of physicians, 4.01 ± 4.11 per 10 000 population for density of pharmacists, 4.11 ± 4.32 US dollars for net official development assistance received by the medical research and basic health sector per capita, 63.65 ± 20.31 for average of 13 International Health Regulations Core Capacity Scores, 10. 41 ± 5.17% for the percentage of government health expenditure, 68.00 ± 28.65% for the percentage of the population using safely managed sanitation services, 66.05 ± 95.28 million US dollars in official development assistance (ODA) provided through government-coordinated expenditure plans specifically for water and sanitation, and 0.587 ± 0.190 for the inequality-adjusted Human Development Index (HDI). …”
Get full text

Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple‐Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1‐Regulated Cholesterol Metabolism by Yilan Yang, Jiatao Liao, Zhe Pan, Jin Meng, Li Zhang, Wei Shi, Xiaofang Wang, Xiaomeng Zhang, Zhirui Zhou, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Yi‐Zhou Jiang, Zhi‐Min Shao, Fei Xavier Chen, Xiaoli Yu, Xiaomao Guo

“…This effect is achieved through reduced activity of the transcription factor forkhead box M1 (FOXM1), which normally increases cholesterol production by inducing SREBF1 expression. …”
Get full text

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

“…TMT-MS experiments reveal a select group of off-targets, including PCNA clamp-associated factor PCLAF and ribonucleoside-diphosphate reductase subunit M2 (RRM2), that are similarly depleted by XL44 treatment. …”
Get full text

Deregulated methylation and expression of PCDHGB7 in patients with non-small cell lung cancer: a novel prognostic and immunological biomarker by Yue Yuan, Yue Yuan, Xin Nie, Jiayi Gao, Jiayi Gao, Yumeng Tian, Yumeng Tian, Liuer He, Liuer He, Xue Wang, Ping Zhang, Junling Ma, Lin Li, Lin Li

“…The methylation level of PCDHGB7 was upregulated in tumor tissue and negatively correlated with PCDHGB7 mRNA level. In immunotherapy cohort studies, patients with higher PCDHGB7 tissue expression showed worse prognosis. …”
Get full text

Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis by Min Hu, Xinyu Meng, Tong Wang, Yifan Wang, Xiaodong Chen, Dongliang Xu, Wei He, Hongjia Zhang, Wenzheng Guo, Bo Jing, Siwei Zhang, Jianhua Xu, Beibei Sun, Xueqian Sun, Tingting Liu, Na Ni, Tongtong Zhang, Wenwen Cui, Xiaoyu Wu, Liping Xia, Feng Yao, Fang Zhang, Jing Du, Jiong Deng

“…The lymphocytes from lymph nodes and tumor tissues exhibited greatly enhanced activities of Th1 cells and M1 macrophages. Conclusion Immunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.…”
Get full text

LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…Results Genetic editing of CD38 universal CAR-T cells, including CD38, T cell receptor alpha constant (TRAC), beta-2-microglobulin (B2M), and class II major histocompatibility complex transactivator (CIITA) knockdowns, was successfully achieved. …”
Get full text

Technological dental sealants: in vitro evaluation of material properties and antibiofilm potential by Witalo Pereira de Jesus, Luiza de Almeida Queiroz Ferreira, Washington Henrique Themoteo da Silva, Fernanda Vieira Belém, Ana Paula Turrioni, Cláudia Silami de Magalhães, Mila Fernandes Moreira Madeira, Ivana Márcia Alves Diniz, Marco Aurelio Benini Paschoal

“…For the MBS test, specimens were made in bovine enamel with the addition of the experimental group FluroShield® (Dentsply) + Single Bond Universal® adhesive (3 M)(G5) and measured in a universal testing machine. …”
Get full text

The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…Lactylation, for example, activates genes such as Arg1, which is a hallmark of the M2 macrophage phenotype implicated in immunosuppression and tumor growth. …”
Get full text

Eco-friendly sustainable farming: Enhancing summer tomato (Lycopersicon esculentum mill.) yield with jute non-woven agro textile Mulch by Nilimesh Mridha, Dipak Nayak, Ashok Yadav, Tilak Mondal, Rakesh Kr Ghosh, Manik Bhowmick, Atul Singha, D.P. Ray, B.S. Manjunatha, Avijit Das, D.B. Shakyawar, Sourav Paul, Amit Das, Santanu Mukherjee, Ravinder Kumar

“…Jute non-woven mulch with 100 % jute (100:0) of 250, 450, and 650 g per square meter (GSM), the blend non-woven of pure jute with caddis (50:50) of 250, 450, and 650 GSM, plastic (50 μm) and rice straw mulch were evaluated on summer tomato crop at the ICAR-CISH regional station in Malda, West Bengal, India. …”
Get full text

Facilitating free travel in the Schengen area—A position paper by the European Association for Biometrics by Christoph Busch, Farzin Deravi, Dinusha Frings, Els Kindt, Ralph Lessmann, Alexander Nouak, Jean Salomon, Mateus Achcar, Fernando Alonso‐Fernandez, Daniel Bachenheimer, David Bethell, Josef Bigun, Matthew Brawley, Guido Brockmann, Enrique Cabello, Patrizio Campisi, Aleksandrs Cepilovs, Miles Clee, Mickey Cohen, Christian Croll, Andrzej Czyżewski, Bernadette Dorizzi, Martin Drahansky, Pawel Drozdowski, Catherine Fankhauser, Julian Fierrez, Marta Gomez‐Barrero, Georg Hasse, Richard Guest, Ekaterina Komleva, Sebastien Marcel, Gian Luca Marcialis, Laurent Mercier, Emilio Mordini, Stefance Mouille, Pavlina Navratilova, Javier Ortega‐Garcia, Dijana Petrovska, Norman Poh, Istvan Racz, Ramachandra Raghavendra, Christian Rathgeb, Christophe Remillet, Uwe Seidel, Luuk Spreeuwers, Brage Strand, Sirra Toivonen, Andreas Uhl

Get full text

Structural basis of FpGalNase and its combination with FpGalNAcDeAc for efficient A-to-O blood group conversion by Meiling Zhou, Kaishan Luo, Chao Su, Yan Sun, Zuyan Huang, Shuo Ma, Xun Gao, Jiwei Wang, Chen Zhang, Pengcheng Han, Guoqiu Wu

“…We optimized treatment conditions, achieving over 99% conversion in just five minutes using phosphate buffer saline and a 16 nM enzyme concentration. Additionally, we engineered two fusion proteins, FpGalNAcDeAc-FpGalNase and FpGalNase-FpGalNAcDeAc, which showed a 28-fold increase in catalytic efficiency compared to the enzyme mixture. …”
Get full text

Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…We here aim to comprehensively analyze the mRNA expression of FNDC1, FNDC3A, FNDC3B, FNDC4, FNDC5, and GPR116 in nonaffected and affected mucosal samples of patients with IBD or colorectal cancer (CRC). …”
Get full text

Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…For instance, in 2021, 22.3% of women were over 35 years old, 17.7% were born outside of France, 11.3% had a body mass index (BMI) of 30 kg/m2 or higher, and 39.9% were primiparous. Episiotomy and OASI (third- and fourth-degree tears) were identified from medical records. …”
Get full text