Clinical Features and Changes in Insulin Requirements in People with Type 2 Diabetes Requiring Insulin When Hospitalised with SARS-CoV-2 Infection by Antonella Corcillo, Aaisha Saqib, Niruthika Sithamparanathan, Amina Khanam, Jamal Williams, Abhiti Gulati, Dulmini Kariyawasam, Janaka Karalliedde

“…People requiring insulin were younger, had a higher preadmission HbA1c, were more frequently on oral medication for diabetes before the admission, and were more likely to be obese (body mass index ≥30 kg/m2), with p ≤ 0.001 for all. In multivariable logistic regression analyses, we observed that younger age and higher HbA1c before admission were independently associated with needing insulin, with one-year increase in age associated with decreased odds of needing insulin initiation (OR 0.91, 95% CI 0.83–0.99), and increasing preadmission HbA1c by 1 mmol/mol associated with an increased odds of insulin initiation (OR 1.05, 95% CI 1.002–1.11) (p < 0.05 for both). …”
Get full text

3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules by Woo-Youl Maeng, Yerim Lee, Szu-Han Chen, Kyung Su Kim, Daeun Sung, Wan-Ling Tseng, Gyu-Nam Kim, Young-Hag Koh, Yuan-Yu Hsueh, Jahyun Koo

“…This work further demonstrates that the addition of dyes can enable high-resolution printing, resulting in the achievement of fine multichannels with a diameter of 200 μm. In vivo animal studies using a rat sciatic nerve gap model show that GelMA/PEGDA-based multichannel NGCs can significantly improve peripheral nerve regeneration, as indicated by improved paw sensory recoveries, increased hindlimb gait function, and muscle fiber regeneration. …”
Get full text

Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis by Qi Jin, Ge Xu, Yuchen Ying, Lumin Liu, Huimin Zheng, Shifen Xu, Ping Yin, Yuelai Chen

“…NPIs significantly reduced serum testosterone (SMD = -0.57; 95% CI: -0.86 to -0.29, p < 0.01), A4 (SMD = -1.37; 95% CI: -2.63 to -0.12, p = 0.03), and mFG score (WMD = -0.81; 95% CI: -1.26 to -0.37, p < 0.01). …”
Get full text

Modulation of brain activity in brain-injured patients with a disorder of consciousness in intensive care with repeated 10-Hz transcranial alternating current stimulation (tACS): a... by David Williamson, Francis Bernard, Stefanie Blain-Moraes, Caroline Arbour, Virginie Williams, Louis de Beaumont, Catherine Duclos, Béatrice P De Koninck, Daphnee Brazeau, Amelie A Deshaies, Marie-Michele Briand, Charlotte Maschke

“…The intervention includes a 20 min 10 Hz tACS at 1 mA intensity or a sham session over parieto-occipital cortical sites, repeated over five consecutive days. …”
Get full text

Prediction Models of Severity in Acute Biliary Pancreatitis by Iulia Ratiu, Renata Bende, Camelia Nica, Oana Budii, Calin Burciu, Andreea Barbulescu, Tudor Moga, Bogdan Miutescu, Roxana Sirli, Mirela Danila, Alina Popescu, Felix Bende

“…In univariate analysis, the following parameterswere associatedwith at least a moderate–severe form of acute pancreatitis: Balthazar score, fasting blood glucose (mg/dL), modified CTSI score, CRP values at 48 h, BISAP score at admission, CTSI score, Ranson score, duration of hospitalization (days), and the presence of leukocytosis (×1000/µL) (all <i>p</i> < 0.05).BISAP score at admission (AUC-0.91), CRP levels at 48 h (AUC-0.92), mCTSI (AUC-0.94), and CTSI score (AUC-0.93) had the highest area under the curve (AUC) for predicting the severity of acute pancreatitis. …”
Get full text

High-fat diet-induced liver injury in Channa argus through lipid metabolism, anti-oxidative status, apoptosis, and inflammation by Jiaxin Tian, Ying Li, Jiwu Wan, Zhinan Yang, Guiqin Wang

“…At 90 days, the L22 group exhibited a significant upregulation of mRNA expression levels for liver inflammatory factors, including interleukin-1β (IL-1β), IL-8, IL-10, and tumor necrosis factor-α (TNF-α). …”
Get full text

Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency by Fabiola Del Carpio-Cano, Natthapol Songdej, Liying Guan, Guangfen Mao, Lawrence E. Goldfinger, Jeremy G.T. Wurtzel, Kiwon Lee, Michele P. Lambert, Mortimer Poncz, A. Koneti Rao

“…Results: Platelet F13A1 mRNA and protein were decreased in our index patient and in 2 siblings from an unrelated family with RHD. …”
Get full text

Endoplasmic reticulum stress in the salivary glands of patients with primary and associated Sjögren’s disease, and non-Sjögren’s sicca syndrome: a comparative analysis and the infl... by Graziela Vieira Cavalcanti, Fabiola Reis de Oliveira, Rafael Ferraz Bannitz, Natalia Aparecida de Paula, Ana Carolina Fragoso Motta, Eduardo Melani Rocha, John Chiorini, Hilton Marcos Alves Ricz, Denny Marcos Garcia, Maria Cristina Foss-Freitas, Luiz Carlos Conti de Freitas

“…Histopathological analysis and mRNA expression analysis of genes associated with ERS and UPR (PERK, XBP1, ATF-6, ATF-4, CANX, CALR, CHOP, and BIP) were performed on the samples. …”
Get full text

Utilizing ultrasound for the extraction of polysaccharides from the tuber of Typhonium giganteum Engl.: Extraction conditions, structural characterization and bioactivities by Xi Peng, Jing-Ya Wang, Kui-Xu Gao, Zhi-Kun Wang, Qiao-Ling Deng, Yao Wang, Mei-Bian Hu, Yu-Jie Liu

“…Consequently, the optimum extraction conditions predicted by RSM for TGEP-U were obtained as adding water at a ratio of 31 mL/g and extracted for 32 min under an ultrasound power of 440 W. …”
Get full text

Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinen... by Gang Jiang, Fengyuan Yan, Yuanfeng Xu, Jianlin Li, Wenrong Feng, Guo an Hua, Wen jing Li, Jun Zhou, Yongkai Tang

“…This study focused on evaluating hypoxia stress and A. veronii infection in Eriocheir sinensis, and elucidating the molecular mechanisms via biochemical, histopathological and transcriptomic analyses. 360 healthy E. sinensis were equally divided into four groups: a normoxic control (C) at 7.5 ± 0.5 mg/L DO, a hypoxic treatment (Th) at 1.5 ± 0.5 mg/L DO, an A. veronii-infected group (Tv) at 3.5 × 107 CFU/mL under normal DO conditions, and a dual-stress condition (Thv) combining hypoxia and infection. …”
Get full text

Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome by Kun-Chen Lin, Christopher Glenn Wallace, Tsung-Cheng Yin, Pei-Hsun Sung, Kuan-Hung Chen, Hung-I Lu, Han-Tan Chai, Chih-Hung Chen, Yi-Ling Chen, Yi-Chen Li, Pei-Lin Shao, Mel S. Lee, Jiunn-Jye Sheu, Hon-Kan Yip

“…ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed application 0.15 mJ/mm2 for 200 impulses at 6 Hz per left/right lung field. …”
Get full text

Associations of co-exposure to polycyclic aromatic hydrocarbons and vitamin D with early lung dysfunction: Mediating roles of metabolic score-visceral adiposity index by Baihao Lin, Wanlu Liu, Hank-Han Wang, Haixia Qian, Xinyu Zhu, Mengya Xu, Yuyu Zheng, Nada Alhazmi, Yansen Bai

“…Decreased associations of ΣOH-PAHs with FEV1, FVC, and early lung dysfunction, as well as with metabolic score-visceral adiposity index (MSV) were visualized with increased Σ25(OH)D among subjects with body mass index (BMI) < 28 kg/m2. Furthermore, 2.18 %, 18.20 %, 5.70 %, and 4.70 % of the associations of co-exposure to ΣOH-PAHs and Σ25(OH)D with FEV1, FVC, FEV1/FVC, and early lung dysfunction disease were mediated by MSV. …”
Get full text

Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis by Hao Jin, Kongbo Zhu, Lina Wang, Yifan Li, Jingjun Meng, Hong Zhi

“…And it does not coincide with patients taking dabigatran 110 mg with dose reduction for other factors including aged ≥75 years, renal impairment (CrCL 30–50 mL/min), gastritis, esophagitis, or gastroesophageal reflux, receiving concomitant verapamil, and so on. …”
Get full text

Dietary Micronutrient Intake and the Prevalence of Metabolic Conditions among Children from the United States–Affiliated Pacific Region in the Children’s Healthy Living Program by Lucia A Seale, Ashley B Yamanaka, Kristi Hammond, Eunjung Lim, Lynne R Wilkens, Pauline McFall, Tanisha F Aflague, Patricia Coleman, Travis Fleming, Leslie Shallcross, Jonathan Deenik, Rachel Novotny

“…Objectives: The study examined the association between micronutrient intake with body mass index (BMI in kg/m2) and the presence of insulin resistance proxy, acanthosis nigricans (AN), in 3529 children aged 2–8 y from the USAP region in the Children’s Healthy Living study. …”
Get full text

Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study by Yao Wu, BinBin Su, Junqing Xie, Bo Wen, Xiaolan Wu, Mengfan Wang, Yanhui Dong, Yi Song, Jun Ma

Get full text

Corrigendum: Organizational readiness for change towards implementing a sepsis survivor hospital to home transition-in-care protocol by Elaine Sang, Elaine Sang, Ryan Quinn, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Jiyoun Song, Jiyoun Song, Jiyoun Song, Karen B. Hirschman, Karen B. Hirschman, Karen B. Hirschman, Sang Bin You, Sang Bin You, Katherine S. Pitcher, Katherine S. Pitcher, Nancy A. Hodgson, Nancy A. Hodgson, Nancy A. Hodgson, Patrik Garren, Melissa O'Connor, Sungho Oh, Sungho Oh, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles

Get full text

Effect of sun dry brewer spent yeast on chemical composition, in vitro digestibility, and ruminal degradation kinetics of wheat straw by Geberemariyam Terefe, Mulugeta Walelgne, Dereje Fekadu, Getu Kitaw, Mesfin Dejene, Aeimro Kehaliu, Bethlehem Mekonnen, Yohannse Habteyesus

“…The sample (3 g and 2 mm sieve size) with nylon bags (6.5 X 14 cm and 50 μm pore size) was entered sequentially and manually pressed deep into the liquid phase of the ventral sac of the rumen and incubated in the rumens (6, 12, 24, 48, 72, and 96 h) of three fistulated Boran × Holstein–Friesian steers. …”
Get full text

The control effect and induced disease resistance mechanism of Bacillus tequilensis on wheat powdery mildew by Qiuyan Bi, Fen Lu, Jie Wu, Xiangyu Liu, Xiuying Han, Jianjiang Zhao

“…The results revealed that B. tequilensis controlled WPM at an effective concentration of 1 × 107 cfu/mL or higher. The inhibitory effect in vitro was 90.91–100.00 %. …”
Get full text

3-Hydroxyanthranic acid inhibits growth of oral squamous carcinoma cells through growth arrest and DNA damage inducible alpha by Guifang Gan, Xinxia Zhou, Qiaoping Zheng, Xianfu Gao, Xu Chen, Han Zhang, Jinghao Liu, Zhaopeng Shi, Fuxiang Chen

“…Exogenous 3-HAA hampered growth of OSCC cells both in vitro and in vivo. 3-HAA induced growth arrest, G2/M-phase arrest, and apoptosis of OSCC cells. RNA-seq indicated that 3-HAA significantly increased GADD45A expression. 3-HAA promoted transcription of GADD45A by transcription factor YY1. …”
Get full text

Liposome-like encapsulation of fish oil-based self-nano emulsifying formulation for improved bioavailability by Iqbal Ahmad, Aparana Dogra, Tanya Nagpal, Chandvi Sharma, Sudhakar Singh, Nikhil Shaiva, Gaurav Saini, Kanishk Luhach

“…The optimized formulation exhibited significantly smaller particle sizes (100–300 nm), low PDI (0.149–0.303), and a stable zeta potential(-32.5 to -27.9 mV), potentially contributing to improved absorption and stability. …”
Get full text