Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Methods We assessed XPO1 protein and mRNA levels using western blotting and RT-qPCR. …”
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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…The reason may be that the excessive immune response in the severe group at the late stage of DENV infection induces the polarization of macrophages into M2 type, and the macrophages then inhibit T cell immunity through the TGF‐β signaling pathway. …”
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The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis by Mengqian Li, Mengqian Li, Xiaomei Zhang, Yuxin Lai, Yunlong Sun, Tianshu Yang, Xinlei Tan

“…The meta-analysis showed the following: average CT value (MD = 75.57 HU, 95%CI: 44.40–106.75), maximum diameter (MD = 4.99 mm, 95%CI: 4.22–5.77), vascular convergence sign (OR = 11.16, 95%CI: 6.71–18.56), lobulation sign (OR = 3.80, 95%CI: 1.59–9.09), average diameter (MD = 4.46 mm, 95%CI: 3.44–5.48), maximum CT value (MD = 112.52 HU, 95%CI: 8.08–216.96), spiculation sign (OR = 4.46, 95%CI: 2.03–9.81), volume (MD = 1,069.37 mm3, 95%CI: 1,025.75–1,112.99), vacuole sign (OR = 6.15, 95%CI: 2.70–14.01), CTR ≥0.5 (OR = 7.24, 95%CI: 3.35–15.65), vascular type [types III and IV] (OR = 13.62, 95%CI: 8.85–20.94), pleural indentation (OR = 6.92, 95%CI: 2.69–17.82), age (MD = 4.18years, 95%CI: 1.70–6.65), and mGGN (OR = 3.62, 95%CI: 2.36–5.56) were risk factors for infiltration of ground-glass nodules. …”
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Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model by Hua Tao, Jianghao Zhao, Tingting Liu, Yujie Cai, Xu Zhou, Huaijie Xing, Yan Wang, Mingkang Yin, Wangtao Zhong, Zhou Liu, Keshen Li, Bin Zhao, Haihong Zhou, Lili Cui

“…While the relative miR-146a levels significantly increased, the expression of its target mRNAs (IRAK-1 and TRAF-6) and typical inflammatory modulators (NF-κB, TNF-α, IL-1β, and IL-6) decreased, supporting an anti-inflammatory role of miR-146a via the TLR pathway. …”
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Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Com... by Luciana D’Alessio, Hector Konopka, Patricia Solís, Laura Scévola, Mónica Fernandez Lima, Claudio Nuñez, Eduardo Seoane, Silvia Oddo, Silvia Kochen

“…Depression was associated with a higher % of cells with the CB dendritic expression (CB-sprouted cells) (F1,20=11.81, p=0.003, hp2=0.37), a higher CB+ area (μm2) (F1,20=5.33, p=0.032, hp2=0.21), and a higher optical density (F1,20=15.09, p=0.001, hp2=0.43) (two-way ANOVA). …”
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Behavior Changes in Quinpirole Obsessive-Compulsive Disorder Rats Treated with 6-Hydroxydopamine and the Corresponding Dopaminergic Compulsive Loop Mechanism by Haowen Zheng, Rui He, Yang Ming, Haiping He, Wei Wang, Ligang Chen, Feilong Gong

“…Methods: A total of 52 male Sprague Dawley (SD) rats were exposed to either saline (1 mL/kg, NS group, n = 6) or quinpirole (QNP, dopamine D2-agonist, 0.5 mg/kg, n = 46) twice weekly for 5 weeks. …”
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Reproducibility of indirect persistent inward current indicators with neuromuscular electrical stimulation by Timothée Popesco, Davide D'Amato Brunetta, Stefano Pata, Nicolas Place

“…Scientific Reports, 11(1), 6399. https://doi.org/10.1038/s41598-021-85645-0 Heckman, C. J., & Enoka, R. M. (2012). Motor unit. Comprehensive Physiology, 2(4), 2629–2682. https://doi.org/10.1002/cphy.c100087 Mesquita, R. …”
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Bio-carbon composite for supercapacitor electrodes: Harnessing hydrochar frameworks and bio-tar polymerization by Jixiu Jia, Yuxuan Sun, Lili Huo, Lixin Zhao, Ziyun Liu, Zhidan Liu, Kang Kang, Shuaishuai Zhang, Teng Xie, Yanan Zhao, Zonglu Yao

“…And it also showed a maximum specific surface area of 2714.27 m2/g, with a mesopore ratio of 68.79 % at an activation temperature of 800 °C. …”
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High-Resolution Satellite Reveals the Methane Emissions from China’s Coal Mines by Xingyu Li, Tianhai Cheng, Hao Zhu, Xiaotong Ye, Donghao Fan, Tao Tang, Haoran Tong, Shizhe Yin, Jingyu Xiong

“…With a spatial resolution of 60 m and spectral channels from 381 to 2493 nm, the EMIT satellite can finely characterize facility-level methane plumes. …”
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Serum hsa-miR-22-3p, hsa-miR-885-5p, Lipase-to-Amylase Ratio, C-Reactive Protein, CA19-9, and Neutrophil-to-Lymphocyte Ratio as Prognostic Factors in Advanced Pancreatic Ductal Ade... by Jakub Wnuk, Dorota Hudy, Joanna Katarzyna Strzelczyk, Łukasz Michalecki, Kamil Dybek, Iwona Gisterek-Grocholska

“…For NLR, CRP and CA19-9 thresholds were determined using ROC analysis (6.63, 24.7 mg/L and 4691 U/mL, respectively). Cox’s F test for overall survival showed statistically significant differences between groups (<i>p</i> = 0.002 for NLR, <i>p</i> = 0.007 for CRP and <i>p</i> = 0.007 for CA19-9). …”
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2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2 by Yae Jin Yoon, Yu-Jin Lee, Jiyeon Choi, Seung-Wook Chi, Sangku Lee, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Han

“…Treatment of SW620 cancer cells transfected by control vector with 20 μM HCA increased ROS levels by 5.2-fold compared to DMSO-treated cells. …”
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Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series by Giacomo Savini, Alice Galzignato, Catarina P. Coutinho, Jinhai Huang, Yue Wu, Piero Barboni, João Mendanha Dias, Filomena J. Ribeiro, Domenico Schiano-Lomoriello

“…Three months postoperatively, manifest refraction, monocular and binocular uncorrected and corrected visual acuity at 4 m, 66 cm and 40 cm, binocular defocus curve, binocular contrast sensitivity, halometry and Strehl ratio were measured. …”
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A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years by Zixuan Liu, Qinyang Shou, Kay Jann, Chenyang Zhao, Danny JJ Wang, Xingfeng Shao

“…Additionally, ChP volume (mean ± std = 1.72± 0.85 ml) increased (p < 0.01) and ChP perfusion (43.07±14.18 mL/100 g/min) decreased (p = 0.04) with age. These findings underscore the robustness of multi-delay ASL with model-fitting quantification in assessing ChP perfusion, making it the preferred method for accurate CBF and ATT estimation, particularly in regions with prolonged transit time such as ChP.…”
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Altered zygotic gene expression caused by sperm with Tdrd6 variants disrupts early embryonic development by Zhijie Hu, Yuqi Zhang, Renfei Cai, Qiuju Chen, Haiyan Guo, Danjun Li, Weidong Lin, Hongxi He, Haibo Wu, Yali Liu, Bin Li, Qianwen Xi, Hongyuan Gao, Jian Zhang, Qifeng Lyu, Yanping Kuang, Xuefeng Lu

“…Additionally, our research revealed that OAD influences the expression of multitude of genes at the 2‐pronuclear (2PN) stage, with the Mos gene playing a pivotal role in early embryonic arrest. The injection of Mos mRNA can mitigate this arrest. To our knowledge, this is the first study to show that sperm‐related OAD affects gene expression at the 2PN stage and elucidate how AOA overcomes male factor‐derived embryonic arrest, enabling successful pregnancies and live births.…”
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Extensive Atrophic Gastritis Increases Intraduodenal Hydrogen Gas by Yoshihisa Urita, Toshiyasu Watanabe, Tadashi Maeda, Tomohiro Arita, Yosuke Sasaki, Takamasa Ishii, Tatsuhiro Yamamoto, Akiro Kugahara, Asuka Nakayama, Makie Nanami, Kaoru Domon, Susumu Ishihara, Hirohito Kato, Kazuo Hike, Norikok Hara, Shuji Watanabe, Kazushige Nakanishi, Motonobu Sugimoto, Kazumasa Miki

“…At the time of endoscopic examination, we intubated the stomach and the descending part of the duodenum without inflation by air, and 20 mL of intraluminal gas samples of both sites was collected through the biopsy channel. …”
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Kefir Prevents Adipose Tissue Growth Through the Induction of Apoptotic Elements in High-Fructose Corn Syrup-Fed Rats by Esra Aslan, Gokhan Sadi, Hilal Guzel, Cigdem Karaca, Omer Adil Korkmaz, Mine Kanat Pektas, Mehmet Celegen, Tugce Aladag, Seyma Oncu, Mehmet Bilgehan Pektas

“…HFCS (20%, w/v ) was given in drinking water and kefir (1 mL/100 g body weight) by gastric gavage daily for 8 weeks. …”
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Associations between exposure to volatile organic compounds with obesity in adults by Runmiao Wu, Lei Jia, Xu Zhu, Gongchang Guan, Junkui Wang, Rutai Hui, Meijuan Ma, Zhao Zhao, Hui Pang, Ling Zhu

“…The median BMI was 27.7 (24.2, 32.4) kg/m2, and the median waist circumference was 98.0 (87.3, 109.0) cm. …”
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Shexiang Tongxin dropping pills ameliorate myocardial ischemia-reperfusion injury progression via the S1PR2/RhoA/ROCK pathway by Ying Sun, Boyang Jiao, Yizhou Liu, Ran Wang, Qiong Deng, David N. Criddle, Yulin Ouyang, Wei Wang, Xuegong Xu, Chun Li

“…The mechanisms of STDP (50 and 100 ng/mL) were evaluated by examining the expression of sphingosine 1-phosphate receptor 2 (S1PR2), Ras Homolog family member A (RhoA), and Rho-associated coiled-coil-containing protein kinase (ROCK) proteins and the distribution of ZO-1, VE-cadherin, and F-actin proteins in an oxygen and glucose deprivation/reoxygenation model. …”
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Parents' perception of the promotion of physical activity as part of the Purzelbaum project in Swiss daycare centers by Bianca Celine Schmidli, Claudio R. Nigg

“…., Lee, A. S. Y., Capio, C. M., & Chan, D. K. C. (2022). Parental influence on child and adolescent physical activity level: A meta-analysis. …”
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Features of development and progression of colorectal cancer on a background of ulcerative colitis by I. L. Khalif, V. N. Kashnikov, A. V. Gusev, O. V. Golovenko, K. V. Bolikhov, L. L. Kapuller, A. N. Kuznetsov, A. V. Vasilchenko

“…In 12 patients (18,5%) CRC was characterized by primary multifocal with up to 5 tumors in different regions of the large intestine in T4N0M0stage. In 7 (10,8%) cases of 65 the signs of dysplasia of intestinal epithelium were not revealed, in 24 (36,9%) dysplasia of moderate degree and in 34 (52,3%) – high degree was observed. …”
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