GS-DTA: integrating graph and sequence models for predicting drug-target binding affinity by Junwei Luo, Ziguang Zhu, Zhenhan Xu, Chuanle Xiao, Jingjing Wei, Jiquan Shen

“…Conclusions The results show that GS-DTA achieves good performance in terms of MSE, CI, and r2 m on the Davis and KIBA datasets, improving the accuracy of DTA prediction.…”
Get full text

Evaluation of the effect of temperature on cyclic fatigue resistance of three types of Nickel-Titanium rotary files with various alloy properties: An in vitro study by Dara H. Saeed, Fadi A. Rafea

Get full text

Combined effects of topography, soil moisture, and snow cover regimes on growth responses of grasslands in a low- mountain range (Vosges, France) by P.-A. Herrault, A. Ullmann, D. Ertlen

“…Spatial patterns of browning are enhanced on north-facing slopes and at low elevations (<span class="inline-formula">&lt;1100</span> m), where high-producing grasslands with dominant herbaceous communities prevail. …”
Get full text

El chile poblano criollo en la cultura alimentaria del Alto Atoyac by Luis Joaquín Pérez Carrasco, Mario Alberto Tornero Campante, José Sergio Escobedo Garrido, Engelberto Sandoval Castro

“…El sistema de producción predominante en el Alto Atoyac, es el chile poblano criollo intercalado en árboles frutales, con superficies de siembra igual o menor a 100 m2, estrategia usada por los productores para diversificar el riesgo de las enfermedades del cultivo y con ello asegurar la sobrevivencia de sus tradicio-nes culinarias y la permanencia de su semilla con sus propias características. …”
Get full text

Honoring the Afro-Colombian musical culture with the naming of Epipedobates currulao sp. nov. (Anura, Dendrobatidae), a frog from the Pacific rainforests by Mileidy Betancourth-Cundar, Juan Camilo Ríos-Orjuela, Andrew J. Crawford, David C. Cannatella, Rebecca D. Tarvin

“…This species inhabits lowland forests from 0–260 m a.s.l. This taxon differs from congeners by having a combination of bright yellow blotches in the dorsal anterior region of the thigh and upper arm, homogenous dark-brown dorsal coloration, and advertisement calls of long duration and many pulses. …”
Get full text

The influence of exogenous melatonin treatment on quality, nutritional profile, and antioxidant system of fresh-cut carambola during cold storage by Farah Anum Mohd Yusof, Ezzat Mohamad Azman, Noranizan Mohd Adzahan, Noor Liyana Yusof

“…Vacuum impregnation with melatonin (MT) at 100 μM maintained the nutritional value and quality of fresh-cut carambola after 16 days of storage at 4 °C. …”
Get full text

Hop Distance Symmetry Moderately Reflects Knee Biomechanics Symmetry During Landing But Not For Controlled Propulsions by Stefano Di Paolo, Naoaki Ito, Kayla D. Seymore, Haraldur B. Sigurðsson, Laura Bragonzoni, Stefano Zaffagnini, Lynn Snyder-Mackler, Karin Gravare Silbernagel

“… # Study Design Cross-sectional biomechanics laboratory study # Methods Forty-two participants with and without knee surgery (age 28.0 ± 8.0 years) performed the hop test battery which consisted of a single hop for distance, crossover hop, triple hop, and 6-m timed hop in the order listed. Eight high speed cameras were used to collect simultaneous 3D motion data and Theia 3D (Theia Markerless Inc.) was used to generate 3D body model files. …”
Get full text

The structure–activity relationship and computational studies of 1,3-thiazole derivatives as cholinesterase inhibitors with anti-inflammatory activity by Modrić, Marina, Božičević, Marin, Odak, Ilijana, Talić, Stanislava, Barić, Danijela, Mlakić, Milena, Raspudić, Anamarija, Škorić, Irena

“…In our previous research, some screened 1,3-thiazole fragments were found to be potent by inhibiting LPS-induced TNF$\alpha $ and IL-8 release with IC50 values in the $\mu $M range without cytotoxic activity. In the current study, 1,3-thiazole fragments were further investigated as potent cholinesterase inhibitors prompted by the previously documented anti-inflammatory effect of AChE inhibitors. …”
Get full text

An Interactive Clustering-Based Visualization Tool for Air Quality Data Analysis by Mahsa Ashouri, Frederick Kin Hing Phoa, Chun-Houh Chen, Galit Shmueli

“…The tool provides cluster-specific quantitative figures, like seasonal variations in PM2.5 concentration in different air quality zones of Taiwan, and identifies, for example, an annual peak in early January and February (maximum value around 120 µg m−3). Our analysis identifies a region in southernmost Taiwan as different from other zones that are currently grouped together with it by Taiwan EPA (TEPA), and a northern region that behaves differently from its TEPA grouping. …”
Get full text

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. by Ashwin Seetharaman, Himani Galagali, Elizabeth Linarte, Mona H X Liu, Jennifer D Cohen, Kashish Chetal, Ruslan Sadreyev, Alex J Tate, Taiowa A Montgomery, Gary Ruvkun

“…Many synMuv B genes encode dREAM complex chromatin-regulatory proteins found in nearly all animals and plants. We show that mRNAs which are highly induced in synMuv B mutants are congruent with those induced by Orsay RNA virus infection, suggesting that the enhanced RNAi of synMuv B mutants may also be triggered by down-regulation of synMuvB gene activity in an Orsay virus infection of wild type. …”
Get full text

Evaluation of the risk of inferior alveolar nerve injury during an implant procedure: A comparative study between OPG and CBCT by Hassan A. Barzanji, Alan A. Tahir

Get full text

The Effect of Embryo Transfer Process Duration on Implantation Success by Isıl Kasapoglu, Kiper Aslan, Adnan Orhan, Ozge Albayrak, Seyma Haskoylu, Goktan Kuspinar, Berrin Avcı, Gürkan Uncu

“…Day 5 fresh embryo transferred patients aged between 18 - 40, BMI <35 kg/m2 without uterine pathology were enrolled in the study. …”
Get full text

Twelve-Week Quadriceps Strength as A Predictor of Quadriceps Strength At Time Of Return To Sport Testing Following Bone-Patellar Tendon-Bone Autograft Anterior Cruciate Ligament Re... by Joseph P Hannon, Sharon Wang-Price, Shiho Goto, Steven Singleton, Lindsey Dietrich, James Bothwell, Curtis Bush, Craig Garrison

“… # Study Design Cohort Study # Methods A total of 120 participants (males = 55; females =65) were enrolled in the study (age = 16.1±1.4 yrs; height = 1.72±10.5 m; mass = 70.7±16.3 kg). All participants were level 1 or 2 cutting and pivoting sport athletes who underwent a primary bone-patellar tendon-bone autograft ACL-R. …”
Get full text

Physicochemical properties of water quality of Imeh, Edegelem and Chokocho communities located along Otamiri-oche River in Etche Ethnic Nationality of Rivers State, Nigeria by BM Onyegeme-Okerenta, C Obia, MO Wegwu

“…Each sampling points is located 500m away from the successive one, and the samples were taken from the open river at the zone extending beyond the shoreline. …”
Get full text

Optimizing Photovoltaic Array Performance Under Partial Shading Using a Golden Ratio-Based Configuration: A Comparative Analysis of 16 Configurational Variants by Sakthivel Ganesan, Prince Winston David, Hariharasudhan Thangaraj, Devakirubakaran Samithas, Praveen Kumar Balachandran, Muhammad Ammirrul Atiqi Mohd Zainuri

Get full text

نیتروژن‌زدایی جذبی از سوخت به‌کمک جاذب زیستی تهیه شده از پوست سبز گردو by امین علمداری, صدرا رستمی, عباس آقایی نژاد میبدی

“…نتایج فرآیند جذب سطحی نشان داد که جاذب کربن فعال سنتز شده از پوست سبز گردو، ppm 200 ایندول و کینولین را در مدت زمان شش h 6، با مقدار جاذب g 05/0 بر mL 10 سوخت نرمال- هپتان حاوی کینولین و ایندول در دمای ºC 25 به‌ترتیب به‌میزان 26/42 و mg.g-1 68/37 حذف می‌کند. …”
Get full text

Experimental study of mortar incorporating nano-magnetite on engineering performance and radiation shielding by Kunchariyakun Kittipong, Sinyoung Suthatip, MacKenzie Kenneth J. D., Pungkun Vithit, Raknarong Pakkamai, Teh Musofpar, Jekabaso Afham, Sittichan Narumol

“…A 5 wt% addition of nano-Fe3O4 provided the best physical (1,847 ± 19.1 kg m−3), compressive strength (216.79 ± 6.19 ksc at 28 days), and radiation shielding properties, increasing the photon linear attenuation coefficient to 0.155 cm−1 from 0.144 cm−1 in the material without nano-Fe3O4. …”
Get full text

Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents by Joseph Obiezu, Chukwujekwu Ezeonwumelu, Muhammad, Ntale, Steve, Okwudili Ogbonnia, Ezera, Agwu, Julius, Kihdze Tanayen, Ahmed, Adebowale Adedeji, Okonkwo, Chukwudi Onyeka, Ambrose, Amamchukwu Akunne, Jennifer, Chibuogwu Ebosie, Frederick, Byarugaba

Get full text

Public-Private Partnership and Early Childhood Education in Kasese District, Uganda. by Kategaya, Raymond Mwesigye, Adyanga, Akena Francis, Ocan, Johnson

Get full text

Optimization of Soursop (Annona Muricata L.) Leaf Extract in Nanoemulgel And Antiacnes Activity Test Against Propionibacterium Acnes, Staphylococcus Aureus, Staphylococcus Epidermi... by Asyhari, Hanif Fibiana, Cabral, Kibedi B., Wikantyasning, Erindyah R.

“…Particle size, polydispersity index, and zeta potential of the optimal formula were 229.47±38.79 nm, 0.41±0.10, and -39.13±0.19 mV, respectively. Evaluation of nanoemulgel physical properties showed homogeneous, pH value of 5.83±0.24, spreadability of 5.57±0.25cm, the adhesive force of 3.80±0.25 seconds, viscosity of 11479.33±167.49 cP, antibacterial activity against P.acnes, Staphylococcus aureus, and Staphylococcus epidermidis with inhibition zone diameters of 9.67±0.47 mm, 7.33±0.47 mm, and 5.67±0.47 mm. respectively. …”
Get full text