Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…Two recombinant PD-L1xCD3 BiTEs (mBiTE and sBiTE contain anti-PD-L1 scFv region from atezolizumab and from a published sequence, respectively) were able to specifically bind to both CD3 on T lymphocytes, and to PD-L1 overexpressed after gemcitabine treatment on CCA (KKU213A, KKU055, and KKU100) cells. mBiTE and sBiTE significantly enhanced T lymphocyte cytotoxicity against CCA cells, especially after gemcitabine treatment, and their magnitudes of cytotoxicity were positively associated with the levels of PD-L1 expression. …”
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Hooks, Lines, and Sinkers: How Active Galactic Nucleus Feedback and Cosmic-Ray Transport Shape the Far-infrared–Radio Correlation of Galaxies by Sam B. Ponnada, Rachel K. Cochrane, Philip F. Hopkins, Iryna S. Butsky, Sarah Wellons, N. Nicole Sanchez, Cameron Hummels, Yue Samuel Lu, Dušan Kereš, Christopher C. Hayward

“…In doing so, we generally verify the predictions of “calorimeter” theories at high FIR luminosities ( L _60 _μ _m  ≳ 10 ^9.5 L _⊙ ) and at low FIR luminosities ( L _60 _μ _m ≲ 10 ^9.5 L _⊙ ), the so-called “conspiracy” of increasing UV radiation escape in tandem with increasing CRe escape, and find that the global FRC is insensitive to orders-of-magnitude locally variable CR transport coefficients. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…Pharmacological inhibition of Sig-1R with BD1047 (10 μM) abolished Sig-1R-mediated activation of lipopolysaccharide-treated BV-2 microglial cells. …”
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Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…The extracts reduced the DPPH and ABTS radicals, showing a range of IC50 values of 7.35 ± 0.43 - 12.02 ± 0.21 µg/mL. However, the extracts were less toxic to the cells as they showed IC50 values > 20 µg/mL. …”
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Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases by Wei Guo, Bolun Zhou, Lizhou Dou, Lei Guo, Yong Li, Jianjun Qin, Zhen Wang, Qilin Huai, Xuemin Xue, Yin Li, Jianming Ying, Qi Xue, Shugeng Gao, Jie He

“…In this study involving 12 metastatic ESCC patients, we employed single-cell sequencing, spatial transcriptomics (ST), and multiplex immunohistochemistry (mIHC) to explore the spatial and molecular attributes of primary tumor samples, adjacent tissues, metastatic and non-metastatic lymph nodes. …”
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Performance Evaluation of Dual-Drive Mach-Zehnder Modulator and Optomechanical Crystal Cavity Comb Generation for All-Optical Band Conversion in 5G-Advanced Cellular Systems by Vicente Fito, Raul Ortiz, Maria Morant, Laura Mercade, Alejandro Martinez, Roberto Llorente

“…The OMCC implementation provides a reduced footprint (182 <inline-formula><tex-math notation="LaTeX">$\mu \mathrm{m}^{2}$</tex-math></inline-formula>) since it is implemented on a silicon chip and has the extra advantage of generating an optical comb without an external local oscillator, which reduces its power requirements (under 1 mW) while providing a phase noise of <inline-formula><tex-math notation="LaTeX">$-38.3$</tex-math></inline-formula> dBc/Hz at 1 kHz offset and <inline-formula><tex-math notation="LaTeX">$-97.1$</tex-math></inline-formula> dBc/Hz at 100 kHz offset. …”
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Elucidating the effects of manganese on the growth and cadmium accumulation of OsNRAMP5 mutant rice by Xian’an Yu, Qiuqin Zhou, Xin-Yuan Huang, Mingxue Chen, Jiawen Zhou, Tong Zhou, Pengjie Hu, Xia Pan, Miaomiao Cheng, Yongming Luo, Peter Christie, Longhua Wu

“…There was lower biomass of ZA7 than ZZ35 under hydroponic conditions with 0–0.05 μM Mn supply, and this was alleviated at Mn concentrations ranging from 1 to 200 μM. …”
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Sensitive Detection of Lasalocid Residue in Chicken by Surface Enhanced Raman Spectroscopy by Yao WANG, Yingying SUN, Yubing JING, Xiyan YANG, Yanfei LI, Jiaxiang HUANG, Xiujin CHEN, Zhaozhou LI, Li CAO, Huaibin KANG

“…The linear range of this method was 0.55×10−6~0.55 mg/mL, the detection limit was 0.23 ng/mL, the recovery rate of chicken samples was 91.9%~107.3%, and the relative standard deviation was 3.6%~5.7%, which was consistent with the detection results of the national standard method (GB31613.5-2022). …”
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Seed priming induces biochemical changes in melon plants and increase salt tolerance by Jose Castañares, C.A. Bouzo

“…Se evaluó el porcentaje de germinación y crecimiento de las plántulas a una conductividad eléctrica de 8.0 dS m-1. Se midió el contenido total de clorofila, contenido relativo de agua, viabilidad de raíces, contenido de prolina, pérdida relativa de electrolitos, concentración de malondialdehído, actividad peroxidasa y la catalasa, proporción de Na.…”
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FERMENTATIVE-MODIFICATION OF SORGHUM AND MILLET BIOPOLYMERS: IMPACT ON FUNCTIONAL PROPERTIES, PROXIMATE COMPOSITION, AMINO ACIDS AND PROTEIN QUALITY OF MODIFIED FLOURS by SULEIMAN YUSUF BAGIREI, IROH NKAMA, MAMUDU HALIDU BADAU, YAHAYA SAYYADI MOHAMMAD

“…The grains were decanted and dried in a solar dryer at 41 oC, ground and sieved through a 300 μm sieve, while laboratory analyses carried out by standard methods. …”
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. by Monica G Ferrini, Andrea Abraham, Revecca Millán, Leslie Graciano, Sriram V Eleswarapu, Jacob Rajfer

“…NO intracellular content, nitrite formation and cGMP content in culture media, nitric oxide synthase (NOS) isoforms and mRNA content, pro-inflammatory cytokines, and PAI-1 expression and activity were measured. …”
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Optimizing spatial allocation schemes with a focus on carbon fixation services by the integration of GIS and a robust algorithmic approach by Eryan Guo, Jing He

“…When the carbon sequestration weight is 100%, the current savings are greater than those of other optimized scenarios starting in the 35th year, at roughly 8.8 × 104 m3, and the current carbon storage is superior to those of other optimized scenarios starting in the 25th year, at 4.9 × 104 t. …”
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Allelopathic and auto-toxic effects of aqueous extracts of Codonopsis pilosula root secretions. by Daiyu Qiu, Xue Wang, Fengbin Xu, Qian Li, Fengying Ren, Kan Jiang

“…The most pronounced auto-toxic comprehensive effect was observed with extracts at a concentration of 50 mL during the reproductive phase, diminishing SOD and POD activities, and MDA levels in C. pilosula seedlings by 72.3%, 71.7%, and 83.3% respectively, compared to the control (P<0.05). …”
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On stabilization of magnetically charged brane shell and over-extremality by Sohei Tsukahara

“…Moreover, we show the existence of over-extremal states such that (gQ)2 ≥ G 4 m 2 is satisfied in regions where the magnetic field is sufficiently large. …”
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DYSOXYLUM MOLLISSIMUM (SPRENG.) BLUME EX G. DON (MELIACEAE), A NEW RECORD FOR THE FLORA OF VIETNAM by Van Dung Luong, Ngoc Trieu Le, Tan Dat Nguyen, Van Ket Nguyen, Thanh Truong Hoang

“…This species is distributed in primary and secondary forests in scattered populations at elevations of 800–1200 m above sea level in the provinces of Gia Lai and Lam Dong in the Central Highlands of Vietnam. …”
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GLOBAL ACADEMIC TRENDS OF METABOLIC AND ELECTRICAL BIOMEDICAL TOOLS IN MARKETING by Ahmed H. Alsharif, Salmi Mohd Isa, Lina Pilelienė

“…The findings revealed that the United States emerges as the predominant contributor, with 19 papers, while influential authors such as Balconi, M., and the most-cited article, "The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making," signify pivotal contributions to the field. …”
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Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…They have also contributed to groundbreaking discoveries, including the introduction of the first mRNA vaccine (against COVID-19), and have improved certain imaging and diagnostic techniques, too. …”
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Integrated Pest Management for Mosquito Reduction around Homes and Neighborhoods by C. Roxanne Rutledge Connelly, Elizabeth Bolles, D. Culbert, James DeValerio, Michael Donahoe, K. Gabel, R. Jordi, J. McLaughlin, Anita Neal, Sally Scalera, E. Toro, Joseph Walter

“…Culbert, J. DeValerio, M. Donahoe, K. Gabel, R. Jordi, J. McLaughlin, A. …”
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