Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…To assess the impact of these mutations on DNAJC12 expression, we used quantitative real-time PCR and Western blotting techniques to measure mRNA and protein levels, respectively. The Morris water maze test was administered to evaluate the cognitive functions of the mice. …”
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Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…ObjectiveTo evaluate the efficacy and safety of programmed cell death protein 1 or its ligand (PD-1/L1) inhibitors as first-line therapy in advanced or metastatic urothelial carcinoma (mUC) who are ineligible for platinum-based chemotherapy.MethodA systematic search was conducted in four databases (Pubmed, Embase, Web of Science, and the Cochrane Library) to find articles that evaluate the effectiveness of first-line PD-1/L1 inhibitors for mUC, from the establishment of the databases to 22 November 2023. …”
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The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…Results: The six extracts showed variable IC50 values ranging from 1.77 to - 40.97 μg/mL. The most active extracts were C. rotundifolia coded as (stem; BEP-03A and leaves; BEP-03B) on HepG2 cells and showed ∼ 4 and 8 fold selectivity compared to normal MRC5 cells. …”
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An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein... by Chenguang Zhang, Huifeng Liu, Xingwei Jiang, Zhihong Zhang, Xinfeng Hou, Yue Wang, Dangdang Wang, Zongjun Li, Yangchun Cao, Shengru Wu, Sharon A. Huws, Junhu Yao

“…(a genus that was also showed to be linked to the ECM production via the mWASs analysis), GH24 (lysozyme), and 9,10,13-TriHOME (linoleic acid metabolism). …”
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Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

“…We discovered that spireoside controlled blast disease by inhibiting both spore germination and appressorium formation in M. oryzae, primarily through disrupting cell membrane integrity. …”
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Early Postoperative Safety of Total Hip Arthroplasty in Systemic Lupus Erythematosus Patients by YANG Xingdong, YU Muyang, XU Yiming, ZHU Wei, HU Mingwei, WENG Xisheng, FENG Bin

“…After propensity score matching, 163 cases from SLE and control groups were included for analysis. (1) Regarding medical complications, compared with control group, SLE group showed significant differences in osteoporosis, respiratory system disorders, gastrointestinal diseases, urinary system disorders, hematologic abnormalities, and secondary or concomitant rheumatic diseases (all P < 0.05). (2) In terms of preoperative laboratory tests, SLE group had lower platelet counts, absolute lymphocyte counts, hemoglobin levels, hematocrit, albumin levels, blood glucose levels, and activated partial thromboplastin times than control group, while C-reactive protein, erythrocyte sedimentation rate, and D-dimer levels were higher (all P < 0.05). (3) Regarding surgical-related indicators, a higher proportion of patients in SLE group had an ASA grade > 2 (15.95% vs. 3.07%, P < 0.001), but intraoperative blood loss was significantly smaller [324.7 (200.0, 500.0) mL vs. 421.8 (200.0, 500.0) mL, P=0.005]. (4) In terms of complications, SLE group exhibited a significantly higher incidence of major complications than control group (8.59% vs. 1.23%, P=0.005), with a relative risk of 1.081 (95% CI: 1.028-1.136). …”
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Assessing the role of genotype by environment interaction of winter wheat cultivars using envirotyping techniques in North China by Haiwang Yue, Yanbing Wang, Zhaoyang Chen, Jiashuai Zhu, Partha Pratim Behera, Pengcheng Liu, Haoxiang Yang, Jianwei Wei, Junzhou Bu, Xuwen Jiang, Xuwen Jiang, Wujun Ma

“…Conversely, negative correlations were observed with relative humidity at 2 meters (RH2M), total precipitation (PRECTOT), potential evapotranspiration (PETP), and dew point temperature at 2 meters (T2MDEW). …”
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Cool topoclimates promote cold-adapted plant diversity in temperate mountain forests by Borderieux, Jeremy, De Lombaerde, Emiel, De Pauw, Karen, Sanczuk, Pieter, Vangansbeke, Pieter, Vanneste, Thomas, De Frenne, Pieter, Gégout, Jean-Claude, Serra-Diaz, Josep

“…Here we report on growing season understory temperatures using 48 loggers in contrasting topographic features and canopy of a mid-range mountain valley spanning from 475 m a.s.l. to 1203 m a.s.l. in the Vosges Mountains (NE France). …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Further epigenetic and transcriptomic analysis revealed that NAT10 enhances the stability of ERRFI1 mRNA by binding to its coding sequence region in an ac4C-dependent manner. …”
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Identification of key chromium resistance genes in Cellulomonas using transcriptomics by Hongmei Sun, Yongdong Li, Shengchao Gao, Guangchuan Shi, Lianbin Cao, Xinya Li, Tong Li, Tongbiao Li, Mingcheng Wang, Enzhong Li, Junhe Liu, Hongxia Ni, Yi Chen, Ying Liu

“…The results showed that under 0.5 mM Cr(VI) stress, 654 genes were upregulated. Among the upregulated genes, phosphate transport protein encoding genes phoU and TC.PIT, and molybdate transport protein encoding genes modA, modB, and modC were involved in the cell uptake of Cr(VI). …”
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Intrathecal Clonidine versus Dexmedetomidine as Adjuvants to Hyperbaric Ropivacaine in Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Priya Kishnani, Aiman Monaf, Kalpesh Pati, Jatin Patel, Sara Mary Thomas

“…Group RC30 (Ropivacaine+Clonidine) was given 3.5 mL of 0.75% hyperbaric ropivacaine with 30 μg of clonidine, while Group RD5 (Ropivacaine + Dexmedetomidine) was given 3.5 mL of 0.75% hyperbaric ropivacaine along with 5 μg of dexmedetomidine, intrathecally. …”
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Evaluación del Sistema Acuapónico de Pequeña Escala para la Producción de Tilapia y Lechuga by Delia Jazmín Sánchez-Morales, Juan Enrique Rubiños-Panta, Guillermo Crespo-Pichardo, Cándido Mendoza-Pérez, Ma. de Lourdes Pérez-Ávila, Maruja Peralta-Inga, Cesar Enrique Rubiños-Hernández

“…En productividad del agua se obtuvo 10.3 kg m-3 en tilapia y 5 kg m-3 en lechuga. Se concluye que este sistema de producción puede ser una alternativa viable y eficiente a implementar para una producción sustentable de peces y cultivos agrícolas al mismo tiempo.…”
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Levels, Chemical Compositions, and Sources of PM2.5 of Rural and Urban Area under the Impact of Wheat Harvest by Zhiyong Li, Ziyuan Yue, Dingyuan Yang, Lei Wang, Xin Wang, Zhenxin Li, Yutong Wang, Lan Chen, Songtao Guo, Jinsong Yao, Xiao Lou, Xiaolin Xu, Jinye Wei

“…The PM2.5 concentrations at ARS and UA decreased from 156 to 75.5 µg m−3 and from 137 to 53.1 µg m−3, respectively, between the periods during (DWH) and after (AWH) the wheat harvest. …”
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Perencanaan Coverage Jaringan 5G Berdasarkan Propagasi Rugi Rugi Lintasan dan Shadowing by Made Niama Dwi Susila, Linawati Linawati, Nyoman Gunantara

“…Hasil analisis adalah jari-jari yang dihasilkan adalah 70,4479 m dengan luas coverage 0,0129 km2. Jumlah menara rooftop yang diperlukan adalah 366 ditempatkan di balai banjar dan 11.550 ditempatkan di luar balai banjar. …”
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Manejo del Nitrógeno y Densidad de Plantación en Repollo Cultivado en el Noroeste de México by Fidel Núñez-Ramírez, Blancka Yesenia Samaniego-Gámez, Raúl Enrique Valle-Gough, Samuel Samaniego-Gámez, Pedro Iván López Cuen, Isabel Escobosa-García

“…En conclusión, se recomienda el manejo de nitrógeno de 250 kg ha-1 y utilizar la densidad de población de 6.25 plantas m2 a fin de obtener el mayor rendimiento en repollo cultivado en el noroeste de México.…”
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Early initiation of intravenous cyclophosphamide and one‐year outcome in super‐refractory cryptogenic‐new onset refractory status epilepticus by Yasufumi Yorichika, Shuichiro Neshige, Hideaki Sakahara, Narumi Ono, Megumi Nonaka, Yuichiro Tagane, Tomoaki Watanabe, Keisuke Tachiyama, Haruka Ishibashi, Masahiro Nakamori, Takeo Shishido, Shiro Aoki, Hiroki Ueno, Yu Yamazaki, Takahiro Iizuka, Hirofumi Maruyama

“…Early‐treated patients exhibited shorter sedation periods (median 29 vs. 75 days) and better 1 year functional status (mRS 1–2 vs. mRS 4) compared to the late‐treated patient. …”
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Chitosan-multilayered graphene oxide hybrid beads for $\protect \text{Zn}^{2+}$ and metoprolol adsorption by Bouyahmed, Farida, Muller, Fabrice, Richard, Annie, Mostefaoui, Toufik Amayas, Belabbas, Imad, Warmont, Fabienne, Roulet, Marjorie, Reinert, Laurence, Duclaux, Laurent, Delpeux-Ouldriane, Sandrine

“…While pure CS is not efficient for the MTP adsorption, the Langmuir-type isotherms of the 3 wt% MGO hydrogel beads (dose: 5 mg/100 mL) show 163 mg$\cdot $g$^{-1}$ maximum adsorption uptake. …”
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Sistem Kontrol Swarm untuk Flocking Wahana NR-Awak Quadrotor dengan Optimasi Algoritma Genetik by Endra Joelianto, Winarendra Satya Rajasa, Agus Samsi

“…. , dan  yang diperoleh menggunakan AG menghasilkan pergerakan swarm yang baik dengan kesalahan RMS pelacakan 0,0094 m terhadap fungsi obyektif. Sedangkan ketika parameter ,  dan  dicari menggunakan AG, tidak berpengaruh banyak dalam memperbaiki hasil simulasi swarm quadrotor.   …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Oxidative damage-triggered immunogenic cell death (ICD) in turn leads to the polarization of macrophages to the M1 phenotype, inducing immunogenic cell death and inhibiting tumor cell proliferation and metastasis.Discussion: The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. …”
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Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis by Xueqin Huang, Yingqi Yang, Hanlin Zhou, Liping Hu, Annan Yang, Hua Jin, Biying Zheng, Jiang Pi, Jun Xu, Pinghua Sun, Huai-Hong Cai, Xujing Liang, Bin Pan, Junxia Zheng, Haibo Zhou

“…Using this “on-to-off” triggering strategy, the target S. aureus can be recorded in a wide linear range with a limit of detection of 38 CFU/mL in the colorimetric mode and 6 CFU/mL in the SERS mode. …”
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