Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer by Ji Eun Shin, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Byoung Yong Shim

“…The detection rate of the T790M mutation after dacomitinib treatment failure was comparable to that of other second-generation EGFR-TKIs.…”
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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

“…Reversal of EMT by inhibiting GSK-3β/YAP/β-catenin signaling and PI3K/AKT/mTOR signaling contributes to the effect.…”
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SKYSURF. VI. The Impact of Thermal Variations of HST on Background Light Estimates by Isabel A. McIntyre, Timothy Carleton, Rosalia O’Brien, Rogier A. Windhorst, Sarah Caddy, Seth H. Cohen, Rolf A. Jansen, John MacKenty, Scott J. Kenyon

“…Based on this improved modeling, we provide new upper limits on the level of DL of 21, 32, and 25 nW m ^−2 sr ^−1 for F125W, F140W, and F160W. Additionally, by accounting for all known sources of measurement uncertainty, we report lower limits on the level of DL of 12, 20, and 2 nW m ^−2 sr ^−1 for F125W, F140W, and F160W.…”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…Results of physical property evaluation and the dissolution test of D. officinale chewable tablets showed that the water content, adhesion, elasticity, and chewiness were 2.23%±0.92%, 12.75±0.54 mJ, 7.08±0.58 mm, and 0.41±0.67 mJ, respectively, and the cumulative dissolution reached 79.80%±0.75% at 60 min. …”
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Метаболізм кальцію та його фракційного складу у клінічно здорових кіз by Гоцуляк М.М., Сахнюк В.В.

“…Фізіологічні ліміти кальцію іонізованого в сироватці крові клінічно здорових кіз за M±2s наступні: min – 0,47 ммоль/л, max – 1,20 ммоль/л і в 96,6 % досліджених тварин (n=177) ці значення знаходились у визначених межах. …”
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Effect of Biogas Slurry on the Nutrient Cycling and Micro-organisms Community in Two Types of Soil by Pengcheng Li, Dongqi Jiang, Shuqiang Wang, Xianying Zhang, Yulan Zhang, Yonghuan Wang, Zhenhua Chen, Nan Jiang

“…BS is often used in large amounts because of fragmented farmland ownership resulting from previous local policies. In this work, 20 m3 · 667m-2 of BS was applied to black soil twice and to aeolian sandy soil once to explore microbial-driven nutrient cycling. …”
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Accumulation Characteristics and Hydrological Effects of Litter in Mixed Robinia pseudoacacia Plantations by CAO Zetao, DENG Yangxu, TIAN Jing, WANG Bing, LIU Guobin, YANG Yanfen

“…[Results] (1) The total litter accumulation in different mixed R. pseudoacacia plantations ranged from 0.29 to 1.01 kg/m2, with semi-decomposed litter accounting for more than 60% in all cases. …”
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Physicochemical and sensory analysis of fruit juices based on buffalo yogurt whey by Gladis Rébak, Gladys Obregón, Luz Segovia-Espindola, Victoria Cantero, Mariano Pino, Liliana Alegre

“…The objective of this work was to carry out physical-chemical and sensory analysis of juices made with buffalo yogurt whey. The mixtures used 90 mL of whey, 300 mL of fruit juice, and 120 g of sugar in 1 L of filtered water. …”
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Characteristics and Influencing Factors of Soil CH4 and N2O Fluxes in Typical Broad-leaved Forests in the Yangtze River Delta Region, China by JIA Qinqi, XU Fei, CHEN Bingjiang, LU Yanran, CHEN Lihan, HU Jiahao, GUO Na, FANG Shuangxi

“…[Results] The average annual absorption fluxes of CH4 in the soil without litter (S) and soil with litter (SL) treatments were (47.82±18.54), (36.80±13.55) μg/(m2·h), as well as the average emission fluxes of N2O were (80.74±45.24), (52.70±25.98) μg/(m2·h), respectively. …”
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Incidência e Preditores de Desfechos Clínicos em Pacientes com Fibrilação Atrial Valvar e Não Valvar em uso de Antagonistas da Vitamina K by Idelzuita Leandro Liporace, Gustavo Bernardes F. Oliveira, Lucas Bassolli de Oliveira Alves, Nadia Marchiori Galassi, Andreia Dias Jeronimo, Fernanda Maria Lopes, Gregory Y. H. Lip, Álvaro Avezum

“…Incidência anual de eventos tromboembólicos e morte cardiovascular foi 4,4% e preditores foram tromboembolismo prévio (hazard ratio [HR] 2,12; intervalo de confiança [IC] de 95% 1,22 - 3,67), tempo na faixa terapêutica (TFT) < 50% (HR 1,98; IC95% 1,16 - 3,37), e taxa de filtração glomerular (TFG) < 45 mL/min/1.73 m2 (HR 2,76; IC95% 4,82 - 1,58). Taxa de sangramento maior e não maior clinicamente relevante foram 3,24% por ano (IC95% 2,47 - 4,14) e preditores foram sangramento prévio (HR 2,60; IC95% 1,47 - 4,61) e prótese mecânica (HR 1,91; IC95% 1,15 - 3,15). …”
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Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study by Qingzheng Wu, Bing Li, Yuepeng Wang, Yuepeng Wang, Yue Zhang, Qian Wang, Binqi Li, Binqi Li, Wei Jing, Jing Yang, Yiming Mu

“…After adjusting for all factors with the exception of the stratified variable, this association held true in age, sex, BMI, hypertension, and hyperlipidemia subgroup and was especially pronounced in those aged &lt;60 years, BMI ≥24 kg/m2, and males, with interactions between WWI and age, sex, and BMI (P for interaction &lt;0.05).ConclusionWWI was positively associated with T2DM in Chinese urban adults, especially in young and middle-aged males with BMI ≥24 kg/m2.…”
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Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…Additionally, 1.66 log10CFU/mL units of S. aureus within biofilms were killed. …”
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Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning by Xinye Zhu, Kin-Fai Ho, Tzu-Ting Yang, Vincent Laiman, Jian Sun, Zhenxing Shen, Hsiao-Chi Chuang

“…There were 48.30% of PM2.5 was able to deposit in the alveolar area with a concentration of 32.25 µg m–3 estimated by a multiple-path particle dosimetry (MPPD) model. …”
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Evaluating Ultrafine Particles and PM2.5 in Microenvironments with Health Perspectives: Variability in Concentrations and Pollutant Interrelationships by Sheng Xiang, Shaojun Zhang, Yu Ting Yu, Hui Wang, Ye Deng, Qinwen Tan, Zihang Zhou, Ye Wu

“…Similarly, PM2.5 in winter (109 µg m−3) was 3–5 times higher than autumn, while ΔPM2.5 (40 µg m−3) was 3–6 times higher. …”
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Highly Thermally Conductive and Flame-Retardant Waterborne Polyurethane Composites with 3D BNNS Bridging Structures via Magnetic Field Assistance by Hao Jiang, Yuhui Xie, Mukun He, Jindao Li, Feng Wu, Hua Guo, Yongqiang Guo, Delong Xie, Yi Mei, Junwei Gu

“…Highlights By simultaneously incorporating the magnetic filler-modified boron nitride nanosheets (M@BNNS) and the non-magnetic filler U-BNNS into the polymer matrix, a three-dimensional heat conduction pathway composites are obtained under a horizontal magnetic field. …”
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Oxidative alterations in exfoliated oral mucosa cells of patients with major depressive disorder by Lukas Mendes de Abreu, Cintia Rodrigues da Silva, Ana Laura Ferreira Bortoleto, Giovana Barros Nunes, Matheus Martins Gracia, Rafael Akira Tzanno Murayama, Daniel Galera Bernabé, Gisele Zoccal Mingoti

“…Intracellular levels of reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), caspase-3 and -7 activity, and reduced glutathione (GSH) were measured in Arbitrary Fluorescence Units (AFU). …”
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Quantitative proteomics and targeted metabolomics reveal the role of Cassia siamea L. extract in the response to high-fat diet-induced obesity in Drosophila by Ananya Dechakhamphu, Nattapong Wongchum, Theeraphan Chumroenphat, Alongklod Tanomtong, Sirithon Siriamornpun

“…In vitro, CSE significantly inhibited pancreatic lipase activity (IC50 = 67.73±3.24 µg/mL) in a noncompetitive manner. In a high-fat diet-fed Drosophila model, CSE supplementation (10 mg/mL) reduced lipase activity and triglyceride levels and improved body weight, suggesting antiobesity and potential antidiabetic effects. …”
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Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tiss... by Meng-Yun Tsai, Kuo-Tung Huang, Chiann-Yi Hsu, Yi-Hsuan Yu, Pin-Kuei Fu

“…Assessments included the 1MSTS, 6MWT, pulmonary function test (PFT), GAP score, mMRC scale, and Charlson Comorbidity Index (CCI). …”
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Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients by Bo Zhao, Nobuyuki Kanematsu, Shuri Aoki, Shinichiro Mori, Hideyuki Mizuno, Takamitsu Masuda, Hideyuki Takei, Hitoshi Ishikawa

“…Results: Compared to the conventional plans, the boost plans delivered clinically acceptable dose coverage (D90% and D50%) to the target (PTV2) within 1% differences while significantly increasing the minimum LETd by 16 ∼ 24 keV/μm for the PTVboost (63.9 ± 2.8 vs. 44.0 ± 1.3 keV/μm, p < 0.001). …”
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Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer by Ping’an Ding, Jiaxiang Wu, Haotian Wu, Wenqian Ma, Tongkun Li, Peigang Yang, Honghai Guo, Yuan Tian, Jiaxuan Yang, Limian Er, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

“…This model significantly reduced overtreatment rates from 83.9 to 44.1% in tissue specimens and from 84.4 to 56.0% in liquid biopsies. The 4-mRNA panel showed specificity for T1 GC compared to other gastrointestinal cancers (P < 0.001). …”
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