Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…VPA inhibited the transcription of lipogenic genes and these lipogenic genes showed significant decreases in promoter chromatin accessibility only in the IDH1 MT glioma cell lines tested. VPA inhibited the mTOR pathway and a key lipogenic gene, fatty acid synthase (FASN). …”
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Wind Field Retrieval From Co-Polarized SAR Imagery Without External Wind Direction Assistance by Xianen Wei, Jinsong Chong, Yawei Zhao, Lijie Diao, Xuan Jin

“…Similarly, the RMSE and the absolute value of Bias of wind speed comparison with ECMWF and ASCAT were both within 2.5 and 0.65 m/s, respectively. The retrieved wind direction was relatively consistent with the buoy wind direction, but there was a significant deviation in wind speed comparison. …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…The levels of both CXCL8 mRNA and its protein IL-8 in cancer cells under conditions of glucose deficiency were increased in an NF-κB-dependent manner. …”
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Percepción y manejo de la muerte descendente de mango (Mangifera indica L.) en Actopan, Veracruz, México by Juan Carlos Noa-Carrazana, Norma Flores-Estévez, Felipe Roberto Flores-de la Rosa, Luis Guillermo Hernández-Montiel, Liliana Eunice Saucedo-Picazo

“…El análisis de conglomerados permitió identificar tres grupos distintos de productores: pequeños (PPM, 56 %), medianos (MPM, 16 %) y grandes (GPM, 28 %) productores de mango, cada uno con características específicas en cuanto a superficie de cultivo, manejo agronómico y rendimiento (M = 8,54 ± 3,75 t/ha). La  muerte descendente fue reconocida por todos los productores encuestados; los principales síntomas asociados con la enfermedad son: gomosis, pudrición de ramas y tronco. …”
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Utilizing A Multi-Stage Transition Model for Analysing Child Stunting in Two Urban Slum Settlements of Nairobi: A Longitudinal Analysis, 2011-2014. by Oduro, Michael S., IddiI, Samuel, Asiedu, Louis, Asiki, Gershim, Kadengye, DamazoT.

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Assessment of Hand-Hygiene Practices Among Health Care Workers at Kisoro Hospital, Kisoro District. by Nsenga, Alex

“…Specific objectives of the study were; to examine the level of knowledge of health workers on hand-hygiene practice, to determine the level of adherence to hand-hygiene practice among health workers and to identify key barriers m implementation of hand-hygiene practice among health workers at Kisoro hospital in Kisoro District. …”
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Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? by Christoph Riegler, Christoph Riegler, Viktoria Rücker, Regina von Rennenberg, Regina von Rennenberg, Kerstin Bollweg, Kerstin Bollweg, Bastian Cheng, Anna C. Alegiani, Fabian Flottmann, Marlena Schnieder, Marielle Ernst, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Christoffer Kraemer, Ruben Mühl-Benninghaus, Steffen Tiedt, Steffen Tiedt, Lars Kellert, Hanna Zimmermann, Felix J. Bode, Felix J. Bode, Gabor C. Petzold, Gabor C. Petzold, Franziska Dorn, Jörg Berrouschot, Albrecht Bormann, Kathleen Bernkopf, Silke Wunderlich, Tobias Boeckh-Behrens, Martina Petersen, Lars Udo Krause, Stephan Lowens, Heinrich J. Audebert, Heinrich J. Audebert, Eberhard Siebert, Peter U. Heuschmann, Peter U. Heuschmann, Peter U. Heuschmann, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte

“…We analysed baseline factors, treatment details, and clinical outcomes [Modified Rankin Scale (mRS) at 3 months] over a 5-year period (2017–2021).ResultsWe included 6,251 patients from eight centres. …”
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Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial by Todd Molfenter, Jessica Vechinski, Jee-Seon Kim, Jingru Zhang, Lionel Meng, Jessica Tveit, Lynn Madden, Faye S. Taxman

“…Methods This 2 × 2 design compared high (n = 12) and low (n = 4) dose coaching with and without ECHO in a 12-month intervention and 12 M sustainability period. The national trial included 25 jails and 13 community-based partners. …”
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Identification and Analysis of Key Immune- and Inflammation-Related Genes in Idiopathic Pulmonary Fibrosis by Tan Y, Qian B, Ma Q, Xiang K, Wang S

“…Six distinct immune cells, including naive CD4 T cells, T cells CD4 memory resting, T cells regulatory (Tregs), Monocytes, Macrophages M2, Neutrophils were identified. Real-time quantitative polymerase chain reaction (RT-qPCR) results were consistent with the training and validation sets, and the expression of these key genes was significantly upregulated in the IPF samples.Conclusion: This study identified three key genes (RNASE3, S100A12 and S100A8) associated with immune response and inflammation in IPF, providing valuable insights into the diagnosis and treatment of IPF.Summary: This study focuses on cutting-edge research in IPF, with special attention to the development dynamics and application potential of IPF. …”
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IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury by Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao, Ruidong Li

“…OI promoted the transformation of macrophages into M2 macrophages, and this was inhibited when TIM4 was blocked. …”
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Microstructures and mechanical properties of a 30CrNi2MoV steel/GH4098 joint produced by hot-compression bonding by Shengqing Wu, Sheng Liu, Hexin Wang, Shaofei Ren, Bin Xu, Xiaopeng Zhang, Mingyue Sun

“…Owing to the mutual diffusion of GH4098 and 30CrNi2MoV, the bonding interface becomes an interface band where Al2O3/Ti(C, N) is distributed on the side near GH4098 and Ti(C, N)/M23C6 is distributed on the side near 30CrNi2MoV. …”
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Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows by Jiawei Zhang, Lei Shi, Xiaorong Zhong, Yunhe Bai, Jun Dou, Lu Zhang, Xiaochao Shi, Bingchun Wu, Zemin Tan, Lin Yan, Jinku Yu, Jingru Zhang, Guo Han, Jiansheng Xiong, Hua Zhang, Xingyuan Cao, Haoshu Luo

“…Through ovarian weight gain, superovulation and fertility testing assays, our results revealed that a single rpFSH-pFc treatment could effectively promote follicular development and maturation in vivo. Meanwhile, the mRNA expression levels of the target genes associated with follicular development, maturation and ovulation were significantly up-regulated after rpFSH-pFc treatment. …”
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ارزیابی جامع آسیب سازند سیالات مجرابند جدید by جواد مهدوی کلاته نو, احسان خامه‌چی, پارسا کاظمی حکم آباد

“…همچنین نتایج حاصل از آزمایش تورم رس نشان می‌دهد که میزان تورم رس ناشی از هر دو سیال کمتر از mL 5 در g 2 رس می‌باشد. از این‌رو این سیالات می‌توانند به‌عنوان سیال مجرابند در چاه‌های نفت و گاز استفاده شوند و بهره وری و ایمنی را به ویژه در مخازن چالش برانگیز با دما و فشار بالا و نفوذپذیری کم افزایش دهند.…”
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Propiedades psicométricas de la Escala de Comunicación Familiar en estudiantes universitarios / Psychometric Properties of the Family Communication Scale in College Students by Anthony John Erik Copez-Lonzoy, David Villarreal-Zegarra, Ángel Paz-Jesús

“… El objetivo del presente trabajo es analizar las propiedades psicométricas de la Escala de Comunicación Familiar (FCS) en una muestra de 491 estudiantes de una universidad privada en Lima Metropolitana, cuyas edades oscilan entre 16 y 28 años (M = 20.31, DE = 3.08). La muestra se dividió en dos grupos proporcionales. …”
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The water footprint of lithium extraction technologies: Insights from environmental impact reports in Argentina's salt flats by Walter Fernando Díaz Paz, Lucas Seghezzo, Ariela Griselda Salas Barboza, Melisa Escosteguy, Paula Valentina Arias-Alvarado, Eduardo Kruse, Marc Hufty, Martín Alejandro Iribarnegaray

“…Total WF was 51.0 and 135.5 m3/ton of lithium carbonate (Li2CO3) for Olaroz and Fénix, respectively. …”
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Adsorptive removal of toxic heavy metal and dyes from wastewater by rice husk (lignocellulosic biomass) derived activated biochar: A fixed-bed column adsorption study by Md. Mahmudur Rahman, Mohd. Maniruzzaman, Nor ealam, Parvej Mahmud, Sumiya Khatun, Md. Kaowsar Hossain, Md. Ismail Hossain, Md. Hasanuzzaman, Md. Ashraful Alam, Md. Al-amin, Bijoy Chandra Ghos

“…As per the findings it has been stated that the synthesized FRHBC adsorbents have possessed a promizing 2D honeycomb-like well-oriented mesoporous surface microstructure with a larger surface area around 36.84 m2/g. Additionally holds substantial active binding sites, lower crystallinity nearly 23±0.03%, and higher thermal stability upto 700 °C. …”
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Characteristics of Soil Active Carbon Fractions and Carbon Pool Stability in Major Forest Types in Northern Daxing’an Mountains by LIU Beibei, CAI Tijiu

“…[Results] (1) From May to September, soil total organic carbon (TOC), highly active organic carbon (LOC-H) and moderately active organic carbon (LOC-M) of the four forest types showed a “single-peak” trend of change, and reached a peak in August, and the contents were higher in broad-leaved forests than in coniferous forests. (2) The utilisation rate of soil stability organic carbon (ER4) fluctuated between 72.33% and 85.11% from May to September, it was significantly higher than the utilisation rates of the other three types of active carbon, and dominated the soil carbon pool. (3) Soil carbon pool activity (CPA) fluctuated between 0.20 and 0.38, with P. davidiana forests>B. platyphylla forests>P. sylvestris var. mongolica forests >L. gmelinii forests; that of coniferous forests peaked in August, while that of broad-leaved forests were highest in May. (4) Soil active organic carbon content and carbon pool stability were subject to the combined effects of climatic factors and soil factors. …”
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Simulation and experimental study on olive drop injury by Weike Lan, Haotian Mu, Di Xin, Shijia Pan, Yuncai Yan, Wen Gao, Zijie Niu, Dongyan Zhang, Jun Zhang, Yongjie Cui

“…The optimum fall height was below 1.05 m, the contact material was a foam board, and the collision angle was 49.05 °. …”
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Inhibition Mechanism of Pleurotus citrinipileatus Sing. Ergothioneine on Pancreatic Lipase Activity by Zhangchen XIA, Xiaohui MENG, Ru FANG, Yanqing MAO, Junwen CHENG, Yanbin WANG, Juan XU, Liang HE

“…The results showed that the inhibition process of PCEGT on PL was reversible non-competitive with 15.29 mg/mL of the half-maximal inhibitory concentration (IC50). …”
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Influence of minor hydrocarbon seepage on sulfur cycling in marine subsurface sediments by E. Schnabel, A. Vuillemin, C. C. Laczny, B. J. Kunath, A. R. Soares, A. J. Probst, R. Di Primio, J. Kallmeyer

“…The analysis of 50 gravity cores revealed significant variability in the predicted sulfate depletion depth, ranging from 3 to 12 m below the seafloor. We observed nearly linear pore water sulfate and alkalinity profiles, alongside low rates of sulfate reduction (pmol cm<span class="inline-formula">³</span> d<span class="inline-formula">⁻¹</span>). …”
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