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5202
Novel Polymorphism in a Promoter of MBL2 Gene Result in Lower MBL Expression in Chronic Infection Caused by HCV
Published 2020-12-01“…The 6bp deletion was statistically decreasing the concentration of MBL below 1µg.mL-1, precisely among non-responder patients. In conclusion, the existence of the new deletion in the promoter region of MBL2 gene and the additional newly detected polymorphisms, reduce the level of MBL protein and as a result impacts on the response to treatment among HCV-infected patients. …”
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5203
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5204
Prediction of inhibitory peptides against E.coli with desired MIC value
Published 2025-02-01“…Feature selection techniques, particularly mRMR, were utilized to refine our model inputs. …”
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5205
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5206
Early and long-term performance evaluation of low NaOH concentrated waste HBP-GGBS based alkali activated composites
Published 2025-03-01“…This study investigates the long-term (365 days) performance of alkali activated composites (AACs) produced using GGBS and waste hollow brick powder (HBP) and activated with a low concentration (6 M) NaOH solution. Furthermore, it evaluated mechanical strength, durability and microstructure properties together, focusing on long-term performance analysis, which is limited in the literature. …”
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5207
O ensino problêmico como via para a formação do pensamento profissional metodológico: O caso do professor de Matemática
Published 2024-12-01“…Galperin sobre o papel da atividade investigativa do sujeito e às de M. Majmutov sobre as situações problêmicas baseadas em contradições dialéticas como fonte do pensamento profissional do professor de Matemática, voltado para a transformação criativa de suas práticas de ensino que potencializam o desenvolvimento intelectual dos estudantes na escola. …”
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5208
The emerging roles of aberrant alternative splicing in glioma
Published 2025-02-01“…Dysregulation of this process, through variations in spliceosome components, aberrant splicing factors and RNA-binding protein activity, disproportionate regulation of non-coding RNAs, and abnormal mRNA methylation, can contribute to the disruption of AS. …”
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5209
Real-time Monitoring of Suspended Particulate Matter in Indoor Air: Validation and Application of a Light-scattering Sensor
Published 2020-07-01“…Additionally, the working range of the tested units was established, and the limits of detection and quantification were found to be 5 and 15 µg m−3, respectively. Finally, in order to serve as an alternative to the gravimetric method, these instruments must be accredited for PM measurement in accordance with standards such as ISO 17025.…”
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5210
Hydroacoustic sensing of seismic events during the Tajogaite volcanic eruption (La Palma, Spain)
Published 2025-02-01“…This study presents marine passive acoustic monitoring data from a moored hydrophone deployed offshore at a depth of 77 m and 7 km from the volcanic vent, both during and after the eruption. …”
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5211
Extending the game immersion questionnaire to online users
Published 2025-02-01“…This study extends the GIQ to capture the immersion experiences of a more expansive cohort of online users beyond gamers.MethodsThe extended GIQ was administered to a cohort of active internet users from Latvia (n = 227), aged 13 to 65 (M = 26.6, SD = 8.4), with 53.7% identifying as female, 33% as male, and 13.2% as nonbinary. …”
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5212
Time to intubation with McGrath™ videolaryngoscope versus direct laryngoscope in powered air-purifying respirator: a randomised controlled trial
Published 2024-01-01“…Methods: To simulate intubation of COVID-19 patients, we randomly assigned 28 elective surgical patients to be intubated with either McGrath™ MAC VL or direct laryngoscope (DL) by specialist anaesthetists who donned 3M™ Jupiter™ powered air-purifying respirators (PAPR) and N95 masks. …”
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5213
Fourth-generation Ceramic Head Fracture in Total Hip Arthroplasty: A Case Report and Literature Review
Published 2025-04-01“…We present a case report of a 69-year-old male with a BMI of 40.01 kg/m2 who suffered a fracture of a 36-mm ceramic femoral head with pseudoacetabular involvement of the polyethylene liner. …”
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5214
Suitability of Bentonite-Stabilized Laterite for Use as a Material for Nuclear Waste Containment in Sub-Saharan Africa
Published 2025-01-01“…Permeabilities of the mixes increased to 4.3E − 12, 5.5E − 12, 3.8E − 11, and 2.5E − 11 m/s, respectively, with 10%, 20%, 30%, and 40% of laterite in the composite. …”
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5215
Second harmonic generation from bound-state in the continuum-hosted few-layers van der Waals metasurface
Published 2025-01-01“…The high conversion efficiency in this work is 1.47 × 10−4 for 6 mW incident power. Moreover, our design is highly thin and can be used for various linear and non-linear applications in optics. …”
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5216
Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity
Published 2025-02-01“…Further focused screening revealed the K187T variant, which exhibited a fourfold increase in catalytic efficiency (k cat /K M ) over wild-type ACE2. Conclusions This work demonstrates the potential of droplet microfluidics for therapeutic peptidase engineering, offering a robust and accessible method to optimize enzyme properties for clinical applications.…”
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5217
Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles
Published 2025-02-01“…Evaluating their biodistribution is crucial for newly developed vaccines, such as lipid nanoparticles –messenger RNA (LNP-mRNA), DNA, and Viral vectors in non-replicated (VVnr), or recombinant virus vaccines. …”
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5218
Low-temperature biodegradation of freshwater dissolved organic matter during winter-to-spring transition
Published 2025-02-01“…Despite limited degradation of colored and fluorescent DOM (CDOM and FDOM, respectively), 84% of the mass-to-charge (m/z) peaks detected using positive ion mass spectrometry were lost in winter DOM after 28-day incubation. …”
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Effects of mixed fermentation on the flavor quality and in vitro antioxidant activity of Zaosu pear-Merlot grape composite alcoholic beverage
Published 2025-01-01“…The optimum fermentation parameters identified using a fuzzy mathematical sensory evaluation model were an initial pH of 4.22, a ratio of M. pulcherrima 346 and S. cerevisiae ES488 inoculated 1.13:1, sequential inoculation time 47.02 h and making temperature 19 °C. …”
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Real-Time Analysis of Event Response Based on RT-Thread
Published 2025-01-01“…And, a thread synchronization experiment based on event response is designed to measure the actual time of thread scheduling on Arm Cortex-M4 microcontroller STM32L431RCT6. The experimental results show that the low-latency piling timing analysis approach proposed in this paper has an error of about 1.5 microseconds compared to the measurement time of the logic analyzer and the theoretical analysis time. …”
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