SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

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Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN) by Khalida Ismail, Boon How Chew, Iliatha Papachristou Nadal, Angus Forbes, Nurul Iftida Basri, Rozita Zakaria, Pamela Phui Har Yap, Veronika Rysinova, Intan Nureslyna Samsudin, Nurain Mohd Noor, Ziti Akthar Supian, Haslinda Hassan, Fuziah Paimin, Siti Rohani Mohamed Alias, Norizzati Bukhary Ismail Bukhary, Madeleine Benton

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Would Cortisol Measurements Be a Better Gauge of Hydrocortisone Replacement Therapy? Congenital Adrenal Hyperplasia as an Exemplar by Peter C Hindmarsh, John W Honour

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Metastatic Breast Cancer Presenting as Fulminant Hepatic Failure: A Case Report and Literature Review by Malcolm S. Trimble, Cameron N. Ghent, David R. Grant, Caroline A. McLean

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On the generalised André–Pink–Zannier conjecture. by Richard, Rodolphe, Yafaev, Andrei

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Treatment of Whiplash-Associated Disorders - Part I: Non-Invasive Interventions by Anne Conlin, Robert Teasell, Sanjit Bhogal, Keith Sequeira

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An Unusual Case of Spontaneous Bladder Perforation with Associated Autodialysis of the Ensuing Urinary Ascites by A. Aber, S. A. Hyder, V. Arumuham

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Generation of Basis Vectors for Magnetic Structures and Displacement Modes by Z. L. Davies, A. S. Wills

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Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions by Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson, Gino van Heeke

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Primary Gallbladder Lymphoma in a Male Patient with No Risk Factors Detected Incidentally by CT Colonography by Monil Karia, Grigorios Mitsopoulos, Ketan Patel, Akkib Rafique, Hemant Sheth

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Probable Linezolid-Induced Pancytopenia by Nita Lakhani, William Thompson, Anne Marie Bombassaro

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Pneumatosis Coli Mimicking Colorectal Cancer by Teresa Jacob, Mohammad Paracha, Marta Penna, Dhili Arul, Jonathan Wilson

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Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes by Anne Dell, Alaa Galadari, Federico Sastre, Paul Hitchen

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Upper Extremity Motor Learning among Individuals with Parkinson's Disease: A Meta-Analysis Evaluating Movement Time in Simple Tasks by K. Felix, K. Gain, E. Paiva, K. Whitney, M. E. Jenkins, S. J. Spaulding

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Effective Variational Data Assimilation in Air-Pollution Prediction by Rossella Arcucci, Christopher Pain, Yi-Ke Guo

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Development of a patient-reported outcomes tool to monitor changes in joint health and wellbeing for young people with haemophilia B by Bladen Melanie, McDonagh Janet, McLaughlin Paul, Gooding Richard, Holder Kerry-Ann, Thind Sharon, Klooster Brittany, Shields Alan, Turner-Bowker Diane M., Chatterton Kaitlin, Leso Allison, Volpi Connor, Sivasubramaniyam Sujan, Abulizi Jiawula, Khan Nisa

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Prospective Changes in Health-Related Quality of Life and Emotional Outcomes in Kidney Transplantation over 6 Years by Konstadina Griva, Jan Stygall, Juan Hui Ng, Andrew Davenport, Mike J. Harrison, Stanton Newman

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Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series by T. Foltynie, C. Magee, C. James, G. J. M. Webster, A. J. Lees, P. Limousin

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