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Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders
Published 2025-01-01“…These techniques enable earlier and more accurate differentiation of movement disorders, including Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, Lewy body and frontotemporal dementia, Huntington’s disease, and dystonia. …”
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Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia
Published 2014-01-01“…In the present study, we questioned whether microglial cells proliferate in the HC of established PD patients versus control subjects or incidental Lewy body disease (iLBD) cases as a prodromal state of PD. …”
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Alpha synuclein and inflammaging
Published 2025-01-01“…The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). …”
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Classifying Dementia Using Local Binary Patterns from Different Regions in Magnetic Resonance Images
Published 2015-01-01“…We explored the use of 2D local binary pattern (LBP) extracted from FLAIR and T1 MR images of the brain combined with a Random Forest classifier in an attempt to discern patients with Alzheimer's disease (AD), Lewy body dementia (LBD), and normal controls (NC). …”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer
Published 2025-01-01“…This structural reconfiguration occurs in a conserved structural kernel shared by a vast number of αS-fibril polymorphs including extracted fibrils from Parkinson’s and Lewy Body Dementia patients. Consistent with reports of anti-parallel β-strands being a defining feature of toxic αS pre-fibrillar intermediates, I1 impacts viability of neuroblasts and disrupts cell membranes, resulting in an increased calcium influx. …”
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Models of Integrated Acute Care for Older Adult Inpatients That Incorporate Integrative Health: An Integrative Review
Published 2025-02-01“…Three integrated acute psychogeriatric-care models were identified: the Admiral Nursing model, the Lewy body dementia Admiral nursing service model, and the Care for Acute Mentally Infirm Elders model. …”
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