Partnering with Palliative Care: A Case Report of Severe Pain in Critical Limb Ischemia Treated Successfully with a Continuous Popliteal Nerve Catheter by Ryan S. D’Souza, Stephanie Shen, Frederick Ojukwu, Halena M. Gazelka, Bridget P. Pulos

“…A 74-year-old female with acute myelogenous leukemia presented with CLI after experiencing left popliteal artery occlusion. …”
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Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice by Huihong Zeng, Jiaoqi Cheng, Ying Fan, Yingying Luan, Juan Yang, Feixuan Wang, Shuo Yang, Lijian Shao

“…Understanding the regulation of fetal liver HSC mobilization into the fetal bone marrow will help us to design proper clinical therapeutic protocol for disease treatment like leukemia during pregnancy. We prospect that fetal cells, including hepatocytes and endothelial and hematopoietic cells, might regulate fetal liver HSC expansion. …”
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Analysis of MicroRNA -155-5p Expression in Patients with Primary Myelofibrosis. by Sarah I. Khaleel, Jaffar N. AlAlsaidissa

“…This results in extramedullary hematopoiesis, variable blood cell deficiencies, hepatosplenomegaly, general symptoms, progression to leukemia, and a reduced lifespan. Myelofibrosis can occur as a de novo myeloproliferative neoplastic disorder or evolve from other myeloproliferative neoplasms, including Polycythemia Vera or Essential Thrombocytosis. …”
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Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy by Qing Nian, Yan Lin, Jinhao Zeng, Yanna Zhang, Rongxing Liu

“…WT1 is highly expressed in various types of solid tumors and leukemia, and its elevated expression is associated with a poor prognosis for patients. …”
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CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation by Jolanta B. Perz, Selma Gürel, Stefan O. Schonland, Ute Hegenbart, Anthony D. Ho, Peter Dreger

“…The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. …”
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Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione by Nebojša Đ. Pantelić, Bojana B. Zmejkovski, Željko Žižak, Nebojša R. Banjac, Bojan Đ. Božić, Tatjana P. Stanojković, Goran N. Kaluđerović

“…In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. …”
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Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration by Bysani Chandrasekar, Srinivas Mummidi, Vincent G. DeMarco, Yusuke Higashi

“…OxLDL-induced cardiotrophin (CT)-1 expression and CT-1 stimulated SMC proliferation and migration in part via leukemia inhibitory factor receptor (LIFR) and glycoprotein 130 (gp130). …”
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Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures by Isaac Dadzie, Shaibu Adams Avorgbedo, Regina Appiah-Opong, Obed Cudjoe

“…The dried samples were tested on human acute T-cell leukemia (Jurkat) and breast adenocarcinoma (MCF-7) cell lines. …”
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The Characterization of L-Asparaginase with Low L-Glutaminase Activity Produced by the Marine <i>Pseudomonas</i> sp. Strain GH-W2b by Woon-Jong Yu, Ha Young Lee, Yong Min Kwon, Seung Seob Bae, Grace Choi, Hyun-Ju Hwang, Dawoon Chung

“…L-asparaginase (ASNase) hydrolyzes L-asparagine to L-aspartic acid and ammonia and has been used as an antitumor agent for the treatment of acute lymphoblastic leukemia. ASNase has also been used to mitigate the suspected carcinogenic effects of acrylamide in foods. …”
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Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab by Ziping Li, Fujing Zhang, Xianghong Jin, Junling Zhuang

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEPs were enriched in cytokine-cytokine receptor interaction and JAK-STAT signaling pathways. Leukemia inhibitory factor (LIF) is the most correlated with other DEPs and thus may play a key role in both enriched pathways, and the level of LIF protein was highest in the BiTe group. …”
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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

“…Main methods: We use young rat model mimicking children leukemia treatment protocol, focusing on the systemic MTX effect on the central nervous system by intraperitoneal (IP) MTX injection. …”
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Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course by Angela McLigeyo, Jamilla Rajab, Mohammed Ezzi, Peter Oyiro, Yatich Bett, Andrew Odhiambo, Matilda Ong’ondi, Sitna Mwanzi, Mercy Gatua, NAOthieno- Abinya

“…Imatinib mesylate is the gold standard for the treatment of all phases of Philadelphia-positive chronic myeloid leukemia. Patients on imatinib treatment may develop cytopenia due to drug toxicity. …”
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Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3 by Marc Beyer, Sabine Classen, Elmar Endl, Matthias Kochanek, Martin R. Weihrauch, Svenja Debey-Pascher, Percy A. Knolle, Joachim L. Schultze

“…In recent years an increase of functional CD4+CD25+ regulatory T cells (Treg cells) has been established for patients with solid tumors, acute leukemias, and lymphomas. We have reported an expanded pool of CD4+CD25high Treg cells in patients with chronic lymphatic leukemia (CLL), multiple myeloma (MM) as well as its premalignant precursor monoclonal gammopathy of undetermined significance (MGUS). …”
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Refractory human cytomegalovirus infection without evidence of genetic resistance in the UL-54 and UL-97 genes in a pediatric hematopoietic stem cell transplant recipient: a case r... by Alejandra Pando-Caciano, Ketty Adid Escudero-Ramirez, Jackeline Carol Rodríguez-Torres, Holger Maita-Malpartida, Holger Maita-Malpartida

“…Here, we present a case of an 8 years-old patient diagnosed with acute myeloid leukemia. Eight months post-diagnosis, the patient underwent TCR-αβ+/CD19+-depleted haploidentical HSCT. …”
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Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults by Eric J Bow, Gerald Evans, Jeff Fuller, Michel Laverdière, Coleman Rotstein, Robert Rennie, Stephen D Shafran, Don Sheppard, Sylvie Carle, Peter Phillips, Donald C Vinh

“…Over the past few years, a new and broader understanding of the epidemiology and pathogenesis of C/IC has emerged and has been coupled with the availability of new antifungal agents and defined strategies for targeting groups at risk including, but not limited to, acute leukemia patients, hematopoietic stem cell transplants and solid organ transplants, and critical care unit patients. …”
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Association between Novel Marker (Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio, and Delta Neutrophil Index) and Outcomes in Sudden Cardiac Arrest Patients by Sang Il Han, Kyoung-Chul Cha, Young Il Roh, Sung Oh Hwang, Woo Jin Jung, Tae Youn Kim

“…The exclusion criteria were as follows: no data on laboratory study, traumatic arrest, age < 18 years, and a history of leukemia, myelodysplastic syndrome, and myelofibrosis. …”
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Clinical Features and Outcome of Mucormycosis by Carlos Rodrigo Camara-Lemarroy, Emmanuel Irineo González-Moreno, René Rodríguez-Gutiérrez, Erick Joel Rendón-Ramírez, Ana Sofía Ayala-Cortés, Martha Lizeth Fraga-Hernández, Laura García-Labastida, Dionicio Ángel Galarza-Delgado

“…Ten patients had diabetes mellitus as the underlying disease, and 6 patients had a hematological malignancy (acute leukemia). Of the diabetic patients, 3 had chronic renal failure and 4 presented with diabetic ketoacidosis. …”
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Neurohypophysial Receptor Gene Expression by Thymic T Cell Subsets and Thymic T Cell Lymphoma Cell Lines by I. Hansenne, G. Rasier, Ch. Charlet-renard, M.-P. Defresne, R. Greimers, C. Breton, J.-J. Legros, V. Geenen, H. Martens

“…Moreover, the restriction of OTR transcription to T cell lines derived from thymic lymphomas may be important in the context of T cell leukemia pathogenesis and treatment.…”
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Bmi1 Severs as a Potential Tumor-Initiating Cell Marker and Therapeutic Target in Esophageal Squamous Cell Carcinoma by Xiaochen Wang, Kang Li, Maosheng Cheng, Ganping Wang, Hui Han, Fangfang Chen, Wenjing Liao, Zhi Chen, Jianwen Chen, Yong Bao, Liang Peng, Demeng Chen

“…Through genetic lineage tracing approach, we found that a group of Moloney murine leukemia virus insertion site 1- (Bmi1-) expressing cell populations present in the invasive front of the esophageal epithelium, providing a continuous flow of tumor cells for ESCC. …”
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Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia by F. Malvestiti, C. Agrati, S. Chinetti, A. Di Meco, S. Cirrincione, M. Oggionni, B. Grimi, F. Maggi, G. Simoni, F. R. Grati

“…Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder included in the broader diagnostic category of myeloproliferative neoplasms, associated with fusion by BCR gene at chromosome 22q11 to ABL1 gene at chromosome 9q34 with the formation of the Philadelphia (Ph) chromosome. …”
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