LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies by Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi

Subjects: “…LAG3…”
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Efficacy of anti-LAG3 and anti-PD-1 combination checkpoint inhibitor therapy against head and neck squamous cell carcinoma in a genetically engineered mouse model by Felipe F. Lamenza, Peyton Roth, Puja Upadhaya, Suvekshya Shrestha, Sushmitha Jagadeesha, Natalie Kazmierowicz, Natalie Horn, Hasan Pracha, Sonali Dasari, Steve Oghumu

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Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentials by Ke Ren, Hayam Hamdy, Abdo Meyiah, Eyad Elkord, Eyad Elkord, Eyad Elkord

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The immune checkpoint LAG-3 is expressed by melanoma cells and correlates with clinical progression of the melanoma by Melanie Wiecken, Devayani Machiraju, Shounak Chakraborty, Eva-Maria Mayr, Bénédicte Lenoir, Rosa Eurich, Jasmin Richter, Nicole Pfarr, Niels Halama, Jessica C. Hassel

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Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma by Qianqian Cao, Yuzhe Zhang, Cheng Cheng, Xiaoyang Wang, Panlong Fan, Jincheng Huang, Zhipeng Dai

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A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies by Chia-Chi Lin, Elena Garralda, Patrick Schöffski, David S. Hong, Lillian L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, Brigette Ma, Chrisann Kyi, Daniel SW Tan, Philippe A. Cassier, John Sarantopoulos, Andrew Weickhardt, Richard D. Carvajal, Jennifer Spratlin, Taito Esaki, Fréderic Rolland, Wallace Akerley, Barbara Deschler-Baier, Lawrence Rispoli, Tanay S. Samant, Niladri Roy Chowdhury, Daniel Gusenleitner, Eunice L. Kwak, Vasileios Askoxylakis, Filippo De Braud

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A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells by Rui Guo, Xiaoyang Chen, Lu Ying, Wenjing Zhang, Zufa Sabeel, Lianhui Zhao, Jian Dong, Yiyang Dong, Zhao Yang

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Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti‐Lag‐3 via reducing FGL1 expression by Jianchu Wang, Wang Wei, Qianli Tang, Libai Lu, Zongjiang Luo, Wenchuan Li, Yuan Lu, Jian Pu

Subjects: “…anti‐Lag‐3…”
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Immunohistochemical expression of PD1, LAG3, and CTLA4 in diffuse large B cell lymphoma, clinicopathological correlation, and prognostic value by Madonna I. William, Dina A Tantawy, Alyaa R. Elsergany, Amira K El-Hawary, Shaimaa M Yussif

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Lag-3 expression and clinical outcomes in metastatic melanoma patients treated with combination anti-lag-3 + anti-PD-1-based immunotherapies by Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer

Subjects: “…LAG-3…”
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The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway by Hongchi Ge, Nan Guo, Yufei Liu, Bin Lang, Xiaowan Yin, Xiaowen Yu, Zining Zhang, Yajing Fu, Haibo Ding, Qinghai Hu, Xiaoxu Han, Wenqing Geng, Hong Shang, Yongjun Jiang

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Lichen Planus-Like Exanthema Induced by Anti-PD-1 and Anti-LAG-3 Combination Immunotherapy Could Potentially Predict the Treatment Response in Metastatic Melanoma by Marek Pasek, Eva Sticová, Emanuel Marques, Vojtěch Tretera, Petr Arenberger, Monika Arenbergerová

Subjects: “…melanoma, anti-PD-1, anti-LAG-3, adverse events…”
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Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses by Markus Zettl, Melanie Wurm, Otmar Schaaf, Sven Mostböck, Iñigo Tirapu, Ilse Apfler, Ivo C. Lorenz, Lee Frego, Cynthia Kenny, Michael Thibodeau, Elisa Oquendo Cifuentes, Markus Reschke, Jürgen Moll, Norbert Kraut, Anne Vogt, Jonathon D. Sedgwick, Irene C. Waizenegger

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PD-1 and LAG-3 were optimal combination of immune checkpoints for predicting poor clinical outcomes of patients with ovarian cancer by Yifan Wu, Cunte Chen, Yingwen Cui, Ruoyao Zou, Yaoxiang Yang, Fengjie Sun, Yanzi Du, Peipei Wang

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Prognostic nutrition index reveals LAG3 in cytotoxic CD8+ T cells and MHC class II in gastric cancer cells by Chikanori Tsutsumi, Kenoki Ohuchida, Masaki Imamura, Bryan Tan, Yuki Shimada, Kiwa Son, Takaaki Kosai, Naoki Katayama, Yuki Mochida, Sayuri Hayashida, Chika Iwamoto, Nobuhiro Torata, Kohei Horioka, Koji Shindo, Yusuke Mizuuchi, Naoki Ikenaga, Kohei Nakata, Yoshinao Oda, Masafumi Nakamura

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New horizons in B-cell lymphoma immunotherapy: From immune checkpoints to precision medicine by RuiXin Zheng, YuXiao Li, KaiXin Shi, YuanYuan Pan, KaiYi Liu, JinCheng Song, Li Li

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The clinicopathologic characteristics and tumor immune microenvironment of pulmonary enteric adenocarcinoma by Lan Yang, Lingru Chen, Jiali Gong, Hongyang Lu

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Noninvasive Immunotyping and Immunotherapy Monitoring of Lung Cancers via Nuclear Imaging of LAG‐3 and PD‐L1 by Lishu Zhao, Jianxian Ge, Ruru Zhang, Hao Wang, Xinyue Liu, Kandi Xu, Yujin Liu, Wencheng Zhao, Wengang Zhang, Li Ye, Zhimin Chen, Jianfeng Zeng, Yayi He, Mingyuan Gao

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Lymphocyte activation gene 3 served as a potential prognostic and immunological biomarker across various cancer types: a clinical and pan‐cancer analysis by Yifan Liu, Yuntao Yao, Xinyue Yang, Maodong Wei, Bingnan Lu, Keqing Dong, Donghao Lyu, Yuanan Li, Wenbin Guan, Runzhi Huang, Guofeng Xu, Xiuwu Pan

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Association of PD-1, LAG-3 and TIM-3 expression on intratumoral CD8 T-cells with response to atezolizumab in a Real-World-Evidence biomarker study for advanced urothelial carcinoma... by Carlos E. de Andrea, Marta Abengozar-Muela, José Ángel Arranz, Miguel Angel Climent, Javier Puente, Ángel Vizcay, Ligia Montero de la Fuente, José Miguel Jurado, Teresa Bonfill, Carmen Santander, José Carlos Villa, Eduardo Pujol, Adriana Carolina Rosero, Jenifer Gomez, Eva María Fernández, Carlos Álvarez Fernández, Ignacio Ramirez, Pablo Arnáiz, Álvaro López-Janeiro, Ignacio Melero, Miguel F. Sanmamed, José Luis Pérez-Gracia

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