Multicentric Reticulohistiocytosis Presenting with Papulonodular Skin Lesions and Arthritis Mutilans by Raya Saba, Shawn G. Kwatra, Bishwas Upadhyay, Aibek E. Mirrakhimov, Farah N. Khan

“…We report the case of a 54-year-old female who was misdiagnosed as having rheumatoid arthritis and underwent numerous joint replacement surgeries for progressively destructive arthritis in her hands, shoulders, hips, and knees. …”
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A Case Report of a Subdural Hematoma following Spinal Epidural prior to a Total Knee Arthroplasty by Brian J. Carlson, David G. Deckey, Henry D. Clarke, Joshua S. Bingham

“…This case report adds to current literature on management of a subdural hematoma following total knee arthroplasty and is particularly important as joint replacement moves into outpatient surgery centers where the orthopedic surgery team becomes the sole patient contact point. …”
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Comparison of CMM and Micro-CT Volumetric Analysis of Polyethylene Tibial Knee Inserts in Total Knee Replacement by Wei Jiang, Cuicui Ji, Huaxing Xiao, Zhongmin Jin, Yuntian Dai

“…Ultrahigh molecular weight polyethylene (UHMWPE) bearings are used widely in orthopaedic joint replacement as a prominent material for improving the longevity, which is dramatically influenced by wear of polyethylene. …”
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Cardiac Transplantation following Cobalt Cardiomyopathy from Bilateral Metal-on-Metal Hip Replacements by Peter Szedlak, Amrik Virdi, Paul Cacciottolo, Stephen Shepherd, Stephen Pettit, Florian Falter

“…He underwent bilateral revision hip arthroplasties and was listed for heart transplantation. Metal-on-metal joint replacement is a rare cause of iatrogenic cobalt toxicity. …”
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Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies by Lisa M. Billesberger, Kyle M. Fisher, Yawar J. Qadri, Richard L. Boortz-Marx

“…Newer injectable therapies are gaining attention as alternatives to medications because of a safer side effect profile and are much less invasive than a joint replacement. Platelet-rich plasma is beginning to replace the more common injectable therapies of intra-articular corticosteroids and hyaluronic acid, but larger trials are needed to confirm this effect. …”
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Tibia Adamantinoma Resection and Reconstruction with a Custom-Made Total Tibia Endoprosthesis: A Case Report with 8-Year Follow-Up by Gilber Kask, Toni-Karri Pakarinen, Jyrki Parkkinen, Hannu Kuokkanen, Jyrki Nieminen, Minna K. Laitinen

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Promoting Articular Cartilage Regeneration through Microenvironmental Regulation by Kai Liu, Bingjun Zhang, Xiaoling Zhang

“…Current treatments of OA include exercise and medications in the early stages and total joint replacement in the late stages. These approaches only relieve pain and reduce inflammation; however, they have significant side effects and high costs. …”
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Rotationplasty with Vascular Reconstruction for Prosthetic Knee Joint Infection by Masahide Fujiki, Shimpei Miyamoto, Fumihiko Nakatani, Akira Kawai, Minoru Sakuraba

“…The mean interval between prosthetic joint replacement and rotationplasty was 10.4 years and the mean interval between the diagnosis of prosthesis infection and rotationplasty was 7.9 years. …”
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Context-Aware Dual-Task Deep Network for Concurrent Bone Segmentation and Clinical Assessment to Enhance Shoulder Arthroplasty Preoperative planning by Luca Marsilio, Andrea Moglia, Alfonso Manzotti, Pietro Cerveri

“…<italic>Goal:</italic> Effective preoperative planning for shoulder joint replacement requires accurate glenohumeral joint (GH) digital surfaces and reliable clinical staging. …”
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The Waterfall Fascia Lata Interposition Arthroplasty “Grika Technique” as Treatment of Posttraumatic Osteoarthritis of the Elbow in a High-Demand Adult Patient: Validity and Reliab... by Giuseppe Rollo, Roberto Rotini, Denise Eygendaal, Paolo Pichierri, Ante Prkic, Michele Bisaccia, Riccardo Maria Lanzetti, Domenico Lupariello, Luigi Meccariello

“…The elbow interposition arthroplasty is a very common procedure performed mainly on active young patients who need great functionality and for whom total joint replacement is contraindicated and arthrodesis is noncompliant. …”
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The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines by Stefan Landgraeber, Marcus Jäger, Joshua J. Jacobs, Nadim James Hallab

“…All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15–25 years of use, due to slow progressive subtle inflammation at the bone implant interface. …”
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Confirmatory Factor Analysis of the Hip Disability and Osteoarthritis Outcome Score (HOOS) and Associated Sub-scales by Emilie N. Miley, Madeline P. Casanova, Scott W. Cheatham, Lindsay Larkins, Michael A. Pickering, Russell T. Baker

“…# Background Hip Disability and Osteoarthritis Outcome Score (HOOS), HOOS-Joint Replacement (JR), HOOS Physical Function (PS), and HOOS-12 item scale have been suggested as reliable and valid instruments for assessing hip disability. …”
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FEATURES HIP ARTHROPLASTY AFTER REDUCTIONRECONSTRUCTIVE INTERVENTIONS OF PROXIMAL FEMUR by B. Sh. Minasov, R. R. Yakupov, T. E. Hairov, I. R. Gafarov, K. K. Sirodzhov, K. K. Karimov, G. .N. Filimonov, A. R. Trubin

“…Results: conducting joint replacement in patients of the main group was accompanied by an increase in the frequency of intraoperative and postoperative complications. …”
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Mitigative Effect of Erythromycin on PMMA Challenged Preosteoblastic MC3T3-E1 Cells by Yi Shen, Weili Wang, Xiaomiao Li, David C. Markel, Weiping Ren

“…Aseptic loosening (AL) is a major complication of total joint replacement. Recent approaches to limiting AL have focused on inhibiting periprosthetic inflammation and osteoclastogenesis. …”
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Simultaneous total hip and knee arthroplasties in hemophilic arthropathy: series of 5 cases by Özgür Mert Bakan, Arman Vahabi, Elcil Kaya Biçer, Fahri Şahin, Kaan Kavaklı

“…Methods: A retrospective database search identified five patients with severe factor 8 deficiencies who underwent simultaneous hip and knee joint replacement surgery between 2002-2018. Preoperative and postoperative evaluations included Harris Hip Score (HHS), Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), range of motion, flexion contracture (FC), Visual Analog Scale (VAS), hip-knee angle, and leg length discrepancy. …”
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Effect of non-contact induction heating on HA coatings and bone cement, an ex vivo study [version 2; peer review: 2 approved, 1 approved with reservations] by Robert Kamphof, Dr. Bart G.C.W. Pijls, Dr. Rob G.H.H. Nelissen, Jeroen Mesman-Vergeer, Dr. Giuseppe Cama

“…Background Prosthetic joint infection is a serious complication that can arise after total joint replacement surgery. When bacteria colonise an orthopaedic implant, they form biofilms that protect them from their environment, making them difficult to remove. …”
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Loosened hip joint prosthesis-decision options by Byser Bonchev, Tsvetoslav Yordanov, Luben Stokov, Teodor Ivanov, Georgi Georgiev, Luben Lubenov Stokov, Kristian Nastev

“… For the period 2013-2015, 36 patients underwent revision surgery because of secondary developed complications after primary hip joint replacement surgery. 14 of them were male and 23 – female, with average age 73 years.  …”
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Robotic Assistance in Unicompartmental Knee Arthroplasty Results in Superior Early Functional Recovery and Is More Likely to Meet Patient Expectations by Meredith P. Crizer, Amer Haffar, Andrew Battenberg, Mikayla McGrath, Ryan Sutton, Jess H. Lonner

“…Outcomes studied included Lower Extremity Functional Score (LEFS), new Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR.), VR/SF-12, Visual Analog Scale (VAS) pain scores, and perioperative opioid consumption. …”
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Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production by Katriina Vuolteenaho, Anna Koskinen, Meiju Kukkonen, Riina Nieminen, Unto Päivärinta, Teemu Moilanen, Eeva Moilanen

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Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…The general outcome of treatment is not acceptable despite current interventions. Therefore, joint replacement surgery is frequently needed by patients with severe OA. …”
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