Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow by Elin Svedlund Eriksson, Marta Lantero Rodriguez, Bente Halvorsen, Inger Johansson, Anna K. F. Mårtensson, Anna S. Wilhelmson, Camilla Huse, Thor Ueland, Pål Aukrust, Kaspar Broch, Lars Gullestad, Brage Høyem Amundsen, Geir Øystein Andersen, Mikael C. I. Karlsson, Malin Hagberg Thulin, Alessandro Camponeschi, Dana Trompet, Ola Hammarsten, Björn Redfors, Jan Borén, Elmir Omerovic, Malin C. Levin, Andrei S. Chagin, Tuva B. Dahl, Åsa Tivesten

Get full text

Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock by Kosaku Masuda, Ryusuke Yoshimoto, Ruoshi Li, Takeshi Sakurai, Arisa Hirano

Get full text

MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway by Qiong Xiang, Hu Lin, Jia-Sheng Tao, Chuan-Jun Fu, Li-Ni Liu, Jing Deng, Xian-Hui Li

Get full text

Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

Get full text

A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

Get full text

Whole genome sequencing in early onset advanced heart failure by Erik Linnér, Tomasz Czuba, Olof Gidlöf, Jakob Lundgren, Entela Bollano, Maria Hellberg, Selvi Celik, Neha Pimpalwar, Philipp Rentzsch, Molly Martorella, Anders Gummesson, Olle Melander, Sebastian Albinsson, Göran Dellgren, Jan Borén, Anders Jeppsson, R. Thomas Lumbers, Sonia Shah, Johan Nilsson, Pradeep Natarajan, Tuuli Lappalainen, Malin Levin, Hans Ehrencrona, J. Gustav Smith

Get full text

Editorial: Revealing the role of mitochondrial gene defects in tumor progression and developing mitochondrial-targeted drugs by Leilei Liang, Yuzhen Gao

Get full text

Assessment of maternal healthcare services among the women of reproductive age in the rural municipality of Nepal: a cross-sectional study by Mukesh Adhikari, Manish Rajbanshi, Anita Karki, Richa Aryal, Bishnu Prasad Choulagai

Get full text

Editorial: Sulforaphane and isothiocyanates in health by Jed W. Fahey, Jed W. Fahey, Diego A. Moreno, Paul Licciardi, Paul Licciardi, Francesco Grassi, Tom C. Karagiannis, Nadia Mazarakis, Nadia Mazarakis

Get full text

KLF4: a multifunctional nexus connecting tumor progression and immune regulation by Yunjie Ju, Wen Xiao, Bryan James Mathis, Ying Shi

Get full text

Viral hepatitis B epidemiology in Sakha republic (Yakutia) by S. I. Semenov, R. G. Savvin, S. G. Nikitina, S. S. Maksimova, V. G. Krivoshapkin, S. S. Sleptsova

Get full text

Pause before action: Waiting short time as a simple and resource-rational boost by Masaru Shirasuna, Rina Kagawa, Hidehito Honda

Get full text

Seurat function argument values in scRNA-seq data analysis: potential pitfalls and refinements for biological interpretation by Mikhail Arbatsky, Ekaterina Vasilyeva, Veronika Sysoeva, Ekaterina Semina, Ekaterina Semina, Valeri Saveliev, Kseniya Rubina

Get full text

Using a Two-Steps Clustering and PCA Analysis for Stratified Chronic Non-Cancer Pain Care: A Retrospective Cross-Sectional Study by Peiró AM, Barrachina J, Escorial M, Aguado I, Margarit C, Grimby-Ekman A

“…Ana M Peiró,1,2 Jordi Barrachina,1 Mónica Escorial,1 Isidro Aguado,1 César Margarit,1,3 Anna Grimby-Ekman4 1Neuropharmacology Applied to Pain (NED), Clinical Pharmacology Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, 03010, Spain; 2Institute of Bioengineering, University Miguel Hernández, Elche, 03202, Spain; 3Pain Unit, Alicante Department of Health -General Hospital, Alicante, 03010, Spain; 4School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenCorrespondence: Ana M Peiró, Alicante Institute for Health and Biomedical Research (ISABIAL), Hospital General Universitario Doctor Balmis, c/Pintor Baeza, 12, Alicante, 03010, Spain, Email apeiro@umh.esPurpose: Given the number of people who suffer from chronic pain and the impact on healthcare resources, it is imperative that the people with pain receive an appropriate matched treatment due and stratified care. …”
Get full text

Improving quality of surgical and anaesthesia care in sub-Saharan Africa: a systematic review of hospital-based quality improvement interventions by Justine Davies, Nataliya Brima, Imran O Morhason-Bello, Andy JM Leather, Vandy Charles

“…Objectives To systematically review existing literature on hospital-based quality improvement studies in sub-Saharan Africa that aim to improve surgical and anaesthesia care, capturing clinical, process and implementation outcomes in order to evaluate the impact of the intervention and implementation learning.Design We conducted a systematic literature review and narrative synthesis.Setting Literature on hospital-based quality improvement studies in sub-Saharan Africa reviewed until 31 December 2021.Participants MEDLINE, EMBASE, Global Health, CINAHL, Web of Science databases and grey literature were searched.Intervention We extracted data on intervention characteristics and how the intervention was delivered and evaluated.Primary and secondary outcome measures Importantly, we assessed whether clinical, process and implementation outcomes were collected and separately categorised the outcomes under the Institute of Medicine quality domains. Risk of bias was not assessed.Results Of 1573 articles identified, 49 were included from 17/48 sub-Saharan African countries, 16 of which were low-income or lower middle-income countries. …”
Get full text

Nutrition and Physical Therapy in the Prevention and Treatment of Endometriosis by Paulina Krzemińska, Maciej Gołębski, Wojciech Nowak, Jagoda Mikołajczyk, Zuzanna Kukla, Stella Mieruszyńska, Izabela Sadowska, Joanna Kołodziej, Mirosław Sawicki, Jakub Włosiański, Sebastian Musialik

Get full text

Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

Get full text

The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

Get full text

Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis by Mahsa Ranjbar, Mehran Rahimlou, Maryam Fallah, Kurosh Djafarian, Hamed Mohammadi

Get full text

Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

Get full text