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Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer
Published 2019-01-01“…Hemocyanins, as opposed to QS-21, had no cytotoxic effect on either oral cancer cell line cultured in vitro, supporting the idea that the antitumor effects of hemocyanins are associated with their modulation of the immune response. …”
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542
Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis
Published 2025-01-01“…While glycosylation is known to regulate various cellular processes, its impact on CAFs activation remains insufficiently explored. …”
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543
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544
Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice
Published 2017-12-01“…This was accompanied by a significant increase in relative monocyte and neutrophil counts and in spleen cellularity. Lamotrigine significantly inhibited ConA-induced splenocyte proliferation in vitro and it significantly inhibited IL-2 and TNF-α secretion in ConA-stimulated splenocytes. …”
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545
The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity
Published 2019-01-01“…Our data confirmed the preservation of the genomic landscape from tumour tissue to GSCs, supporting the relevance of this cellular model to test in vitro new target therapies for GBM.…”
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546
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547
Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis
Published 2025-01-01“…Thyroid hormone (TH) and it most active form triiodothyronine (T3) are crucial in promoting mitochondrial biogenesis and maintaining cellular homeostasis during the stress response, but their role in paraquat (PQ)-induced pulmonary fibrosis isunclear. …”
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548
CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation
Published 2025-12-01“…Both CAV1 and CAVIN-2 emerged as predictors of DM-PAD. In vitro, CAVIN-2 knockdown decreased LDL transcytosis, while CAVIN-2 overexpression increased it. …”
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549
Computational identification of anti-cancer compounds targeting the RNA-binding domain of human FOX-1 protein (RBFOX1)
Published 2025-01-01“…The transcription factor RBFOX1 is essential for cellular proliferation and has shown upregulation in many human cancers. …”
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550
Antifungal activity and mechanism of Phoebe bournei wood essential oil against two dermatophytes
Published 2025-02-01“…Culture plates containing PWEO in vitro tested PWEO inhibition effect of mycelial growth of dermatophytes and the effect of PWEO on hyphal structure was observed by microscopy; the changes of cell membrane permeability and the degree of lipid peroxidation were reflected by measuring cell physiological indexes. …”
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551
EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer
Published 2025-02-01“…Abstract Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. …”
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552
Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7
Published 2025-03-01Get full text
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553
Bi-allelic variants in WDR47 cause a complex neurodevelopmental syndrome
Published 2024-11-01“…The corpus callosum, the largest interhemispheric connection, is formed by the axons of callosal projection neurons through a series of tightly regulated cellular events, including neuronal specification, migration, axon extension and branching. …”
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554
mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae
Published 2025-01-01“…Importantly, the LNP-YidR-SP mRNA vaccine induced strong adaptive humoral and cellular immunity and increased the survivability of mice compared to the other groups. …”
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555
Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer
Published 2025-01-01“…The photothermal performance, cellular uptake and distribution, cytotoxicity, anti-tumor effects, and mechanism of action of GDNPs@ICG were investigated both in vitro and in vivo.Results: GDNPs@ICG were taken up by tumor cells via a lipid-dependent pathway. …”
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556
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557
Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal
Published 2024-12-01“…Future studies should investigate the specific role of variation in host cellular environment on reactivation differences.…”
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558
Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures
Published 2025-01-01“…We also present the in vitro cell viability and biocompatibility of the alloy system. …”
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559
Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway
Published 2025-02-01“…Besides, the activity-based protein profiling (ABPP) was performed to explore the potential targets of DA. Furthermore, cellular thermal shift assay (CETSA) and pulldown-western blot assays were used to validate the conclusion. …”
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560
Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease
Published 2025-01-01“…Consistent results were also obtained in mice and cellular experiments. In addition, we highlighted a specific renal tubular subpopulation with mitophagy phenotype found in single-cell data, and preliminarily validated it with co-localization and increased expression of Pink1 and Gclc in kidney specimens of DKD patients treated with losartan. …”
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