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Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner
Published 2025-01-01“…METTL7B silencing suppressed cell proliferation and tumorigenesis in vitro and in vivo. Besides, METTL7B knockdown induced cell cycle arrest in G1 phase with a reduction in cyclin D1(CCND1), CDK4, and CDK6 levels and an elevation in CDKN2D levels in cells. …”
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502
A bacterial membrane-disrupting protein stimulates animal metamorphosis
Published 2025-02-01“…Here, we show that MACs bind to tubeworm cilia and form visible pores on the cilia membrane surface, which are smaller and less numerous in the absence of Mif1. In vitro, Mif1 associates with eukaryotic lipid membranes and possesses phospholipase activity. …”
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503
Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator
Published 2025-02-01“…In this pilot study, NPs were further labeled with Alexa fluorophore to track and study cellular uptake using fluorescence microscopy, which showed efficient uptake by HEK-α4β2 cells. …”
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504
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance
Published 2025-02-01“…Finally, the MAP3K1 knockdown has shown significant impacts on the cellular behavior of the BGC823 cells. Conclusion This comprehensive assessment provides valuable insights into the role of MAP3K genes in GC, offering avenues for further research and therapeutic exploration.…”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability
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508
Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway
Published 2020-01-01“…Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/Bad ratio, enhancing cellular reactive oxygen species (ROS) accumulation, triggering DNA damage, decreasing mitochondrial membrane potential (MMP), and leading cytochrome c release from mitochondria. …”
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509
Establishment of the first marine mollusk cell line from scallop (Chlamys farreri) trochophore
Published 2025-03-01“…We successfully established the first marine mollusk cell line, providing a valuable cellular tool for mollusk studies.…”
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510
Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS
Published 2025-01-01“…Expression of pyroptosis and insulin resistance markers was analyzed using qRT-PCR, Western blot, and IHC. Additionally, an in vitro model assessed MV's impact on inflammation and insulin resistance. …”
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511
Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy
Published 2025-03-01“…The Nb-GrB conjugation enhances tumor targeting, while a Gv/Sd linker coupled to h-HFn further improves cellular transport and targeting. Additionally, the multimerization of GrB enhances its effectiveness. …”
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512
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Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose
Published 2019-01-01“…The aim of this study was to elucidate the molecular and cellular mechanisms underlying the protective effects of CaD. …”
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514
Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response
Published 2023-08-01“…In parallel, VBL promotes the nuclear translocation of transcription factor EB, inducing lysosome biogenesis and a dramatic increase in phagocytic activity in macrophages.Conclusions This study explored whether manipulating cellular morphology affects macrophage polarization and consequently induces an antitumor response. …”
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515
miR-223 and Chromogranin A Affect Inflammatory Immune Cell Activation in Liver Metastasis of Neuroendocrine Neoplasms
Published 2025-01-01“…We performed flow cytometry of circulating neutrophils in a patient cohort (n = 10) with NEN, microdissection and histology of tumor tissue. Subsequently, in vitro transfections using the well-established human pancreatic NEN cell line (BON), and co-culture experiments with primary macrophages and neutrophils were performed. …”
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516
WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers
Published 2007-01-01“…Furthermore, we and others detected IgM and IgG WT1 antibodies in patients with hematopoietic malignancies, indicating that the WT1 protein was highly immunogenic, and that immunoglobulin class-switch-inducing, WT1-specific, cellular immune responses were elicited in these patients. …”
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517
Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung
Published 2019-01-01“…Porcine has spurred an increased interest in biomedical research models and xenotransplantation, owing to most of its organs share similarities in physiology, cellular composition and size to humans. Therefore, characterization of stem/progenitor cells in porcine organs or tissues may provide a novel avenue to better understand the biology and function of stem cells in humans. …”
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518
Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils
Published 2025-02-01“…Such observations are expanding our current knowledge of vimentin as a structural cellular component towards additional roles as an active participant in cell signaling. …”
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519
RETRACTED ARTICLE: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6
Published 2024-10-01“…A temporal analysis of breast cancer cells using single-cell RNA sequencing provided insights into cellular developmental trajectories and highlighted changes in expression patterns across key genes during disease progression. …”
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520
Is There a Noninvasive Source of MSCs Isolated with GMP Methods with Better Osteogenic Potential?
Published 2019-01-01“…In this study, we evaluate the osteogenic potential of these various stem cell types. Methods. Ten cellular strains obtained from each different source (umbilical cord, orbicularis oris muscle, or deciduous dental pulp) were induced to osteogenic differentiation in vitro, and the bone matrix deposition of each primary culture was quantified. …”
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