Alteration of Mevalonate Pathway in Proliferated Vascular Smooth Muscle from Diabetic Mice: Possible Role in High-Glucose-Induced Atherogenic Process by Guo-Ping Chen, Xiao-Qin Zhang, Tao Wu, Liang Li, Jie Han, Chang-Qing Du

“…Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pathway is changed in proliferated VSMCs during atherogenic process in diabetic mice. …”
Get full text

Wedelolactone Mitigates Alcoholic Steatohepatitis via Modulating the TLR4/MyD88/NF-κB Pathway by Tao Jiang, Bingde Hu, Yongxia Li, Shuihong Yu

“…Cellular immunofluorescence analyses demonstrated WEL’s ability to reduce alcohol-induced TLR4 expression. …”
Get full text

A Mechanistic Study on the Non-genotoxic Carcinogenicity of the Food Contaminant Semicarbazide by Daniel P. Fitzpatrick

“…These changes in the cellular environment could be the initiation mechanism that facilitates the manifestation of cancer in a cell population. …”
Get full text

The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy by Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu

Get full text

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor by Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington

“…FBXW12 causes depletion of endogenous and plasmid-derived IL-22R in lung epithelia, binds the E3 ligase constituent Skp-1, and facilitates ubiquitination of IL-22R in vitro. FBXW12 knockdown with shRNA increases IL-22R abundance and STAT3 phosphorylation in response to IL-22 cytokine treatment. …”
Get full text

GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway by Chenhua Luo, ZhiMing Xiao, WenLong Yang

“…Abstract G-protein gamma subunit 2 (GNG2) plays a vital role in various cellular processes, yet its specific function in colorectal cancer (CRC), particularly in highly invasive cases and brain metastasis, remains unclear. …”
Get full text

Innovations in intestinal organoid technology featuring an open apical surface by Ye Chen, Yi Wang

“…Since the development of the three-dimensional (3D) “mini-gut” culture system, adult stem cell-derived organoid technology has rapidly advanced, providing in vitro models that replicate key cellular, molecular, and physiological properties of multiple organs. …”
Get full text

Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles by Zhang Hongyu, Guo Jingwen, Wang Zhi, Wang Na, Feng Nianping, Zhang Yongtai

“…The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). …”
Get full text

Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in differen... by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…Pt NCs may promote mitochondrial apoptosis by promoting damaging autophagy, thereby promoting cellular demise. This study has confirmed the P53-independent anticancer impact of Pt NCs on osteosarcoma in vitro and in vivo. …”
Get full text

Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases by NaiLi Wei, ZiFang Quan, Hailiang Tang, JianHong Zhu

“…However, the majority of these researches focus on elucidating cellular and molecular mechanisms involving in brain organogenesis or disease development and only a few of them conducted for treating diseases. …”
Get full text

Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…Additionally, molecular docking simulations performed with AutoDock software confirmed the robust binding interactions between ATBC and these core targets, reinforcing our understanding of their interactions. To explore the cellular impact of ATBC, we performed in vitro experiments using osteoblasts (MC3T3-E1) exposed to relevant concentrations. …”
Get full text

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue by Sara Nava, Valeria Sordi, Luisa Pascucci, Carlo Tremolada, Emilio Ciusani, Offer Zeira, Moris Cadei, Gianni Soldati, Augusto Pessina, Eugenio Parati, Mark Slevin, Giulio Alessandri

Get full text

The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine by Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang Fu

“…Compared with silk fibroin in vitro, the oral mucosal epithelial cells survived better on the decellularized ADSC sheets with an intact and consecutive epidermal cellular layer. …”
Get full text

Effects of milk extracellular vesicles from Holstein Friesian and Brown Swiss heat-stressed dairy cows on bovine mammary epithelial cells by S. Castellani, L. Basiricò, A. Maggiolino, C. Lecchi, P. De Palo, U. Bernabucci

“…These findings indicated that the small vesicles of Brown milk triggered cellular defense against heat stress, supporting the Brown Swiss breed's thermotolerance.…”
Get full text

D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes by Jialiang Luo, Tianxing Wu, Jing Zhang, Zhicheng Liang, Weijie Shao, Di Wang, Lei Li, Daming Zuo, Jia Zhou

“…Inflammatory cytokines and cellular differential gene expression levels were measured by real-time PCR. …”
Get full text

Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog by Ting Ye, Jingyuan Li, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Jianyu Wang, H. Rosie Xing

“…We generated the mouse LLC‐SD lung carcinoma CSC cellular model in which Nr5a2 expression was enhanced. …”
Get full text

Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…Additionally, MO-HPA1.0 hydrogel demonstrated effective oxygen-producing and cell migration-promoting functions in both in vitro and cellular experiments. The MO-HPA1.0 group significantly accelerated wound healing in both of mouse skin defect model and rabbit gastrostomy model. …”
Get full text

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…In addition to exhaustion, cellular senescence in tumor-infiltrating T cells (TILs) has recently been identified as an important T cell dysfunctional state induced by various malignant tumors. …”
Get full text

Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

“…Methods This study utilized both in vivo and in vitro models. In the vivo model, 64 Sprague–Dawley rats were employed, with 40 analyzed for survival outcomes. …”
Get full text

Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells by Tim Heemskerk, Celebrity Groenendijk, Marta Rovituso, Ernst van der Wal, Wouter van Burik, Konstantinos Chatzipapas, Danny Lathouwers, Roland Kanaar, Jeremy M.C. Brown, Jeroen Essers

“…Background and purpose: Understanding the cellular and molecular effect of proton radiation, particularly the increased DNA damage complexity at the distal end of the Bragg curve, is current topic of investigation. …”
Get full text