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The Effect of Tumor Angiogenesis Agents on Tumor Growth Dynamics: A Mathematical Model
Published 2025-01-01“…Conclusion: Our results show the ineffectiveness of targeted treatments on the immune system, which has been confirmed by many negative treatment methods in immunotherapies. Tumor-secreted inhibitor factors are essential to regulating the angiogenesis process. …”
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1843
A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review
Published 2025-01-01“…Ongoing research into targeted therapies, immunotherapies, and innovative technologies remains critical to advancing patient care and improving long-term prognosis.…”
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1844
Comprehensive analysis pinpoints CCNA2 as a prognostic and immunological biomarker in non-small cell lung cancer
Published 2025-01-01“…Despite advances in targeted and immunotherapies, overall survival (OS) rates remain suboptimal. …”
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Colon Cancer Genetic and Epigenetic Changes, Etiopathogenesis, Risk Factors, Treatment: Literature Review
Published 2024-06-01“…It highlights the potential of CRISPR/Cas9, immunotherapies, and liquid biopsies in pioneering personalized CRC treatments and early detection. …”
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Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c...
Published 2024-01-01“…If proven safe, PITHAC could be combined with systemic immunotherapies for the management of cancer. Trial registration: ClinicalTrials.gov Identifier: NCT06281860…”
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Dynamic changes in peripheral blood lymphocyte trajectory predict the clinical outcomes of sepsis
Published 2025-02-01“…Incorporating longitudinal trajectory modeling and lymphocyte subsets may improve prognostic risk assessment and guide the selection of immunotherapies tailored to specific immune phenotypes in sepsis patients.Clinical trial registrationhttps://www.chictr.org.cn/showproj.aspx?…”
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1848
Ewing sarcoma – pathomechanisms, standard treatment and new therapeutic perspectives
Published 2025-01-01“…The paper discusses, among other things, treatment attempts based on the role of the EWS-FLI1 protein, epigenetics, tyrosine kinase inhibitors, immunotherapies and the use of nanomedicine and viruses, as well as the difficulties associated with their application. …”
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The impact of integrated genomic analysis on molecular classifications and prognostic risk stratification in endometrial cancer: a Chinese experience
Published 2025-02-01“…Conclusively, large-scale NGS has revolutionized EC management by facilitating rapid molecular subtype identification, guiding tailored adjuvant therapies, targeted treatments, and immunotherapies, and efficiently screening for Lynch syndrome, thereby significantly improving patient outcomes.…”
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Prognostic implications of immune classification based on PD-L1 expression and tumor-infiltrating lymphocytes in endocervical adenocarcinoma
Published 2025-02-01“…Conclusions: TMIT I group within the NHPVA population is most likely to benefit from PD-L1/PD-1 blockade immunotherapies. The immune classification of ECA demonstrates significant prognostic value, suggesting its potential utility in guiding clinical stratification and therapeutic decision-making.…”
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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
Published 2024-12-01“…Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. …”
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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a...
Published 2025-02-01“…To combine them with existing immunotherapies, the intratumoral immune microenvironment needs to be deeply characterised. …”
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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer
Published 2025-01-01“…Sphingomonas and Sediminibacterium were liable to remodulate lipid and essential amino acid degradations to embrace progression after immunotherapies. Microbiome‐derived metabolites reshaped the immune microenvironment in the lower respiratory tract by releasing inflammatory cytokines and chemokines, which was partially achieved by metabolite‐mediated tumoral inflammatory products and reduction of CD8+ effective T cells and M1 phenotypes macrophages in malignant lesions. …”
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A bibliometric analysis of 30 years of research on transarterial radioembolization (TARE) for hepatocellular carcinoma
Published 2025-01-01“…Based on our analysis, future research focus include the clinical comparative studies on the effect of TARE and TACE combined with immunotherapies or targeted therapy, dosimetry, and personalized TARE therapy for HCC.…”
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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice
Published 2025-01-01“…To date, current treatment options primarily involve various chemotherapies, which often prove ineffective and are associated with substantial toxicity. Furthermore, immunotherapies utilizing checkpoint inhibitors have shown limited efficacy in this context, highlighting an urgent need for novel therapeutic strategies. …”
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Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer
Published 2025-01-01“…Based on this, COL1A1 could serve as a promising biomarker for OC prognosis and provide a new perspective for the development of potential immunotherapies for patients with OC.…”
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