Gastric Cancer Mesenchymal Stem Cells Inhibit NK Cell Function through mTOR Signalling to Promote Tumour Growth by Shuwei Guo, Chao Huang, Fengfeng Han, Bin Chen, Ying Ding, Yuanyuan Zhao, Zhihong Chen, Shaodi Wen, Mei Wang, Bo Shen, Wei Zhu

“…The study results revealed that GCMSCs contributed to dysfunctional NK cells involved at least partially in the inhibition of mTOR signalling, suggesting potential directions for NK cell-based cancer immunotherapy.…”
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DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis by Leilei Xia, Ye Wang, Shengyun Cai, Mingjuan Xu

“…Owing to its insidious onset, rapid development, and poor prognosis, ovarian cancer is the fifth most common cause of death in women. Although immunotherapy-related drugs, such as Olaparib, can alleviate ovarian cancer progression, there are no remarkable breakthroughs for its effective treatment. …”
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Disulfidptosis-related immune patterns predict prognosis and characterize the tumor microenvironment in oral squamous cell carcinoma by Xuechen Wu, Boxin Liu, Shi-Zhou Deng, Tengteng Xiong, Lin Dai, Bo Cheng

“…With this model, we can more accurately predict the prognosis of patients with OSCC, as well as assess the potential effects of their TME and immunotherapy.…”
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SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma by Lianxiang Luo, Jiating Su, Yushi Zheng, Fangfang Huang, Riming Huang, Hui Luo

“…Great advances in new immunotherapy strategies have shown encouraging results in lung cancer patients. …”
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Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation by Sonia Aristin Revilla, Cynthia L. Frederiks, Stefan Prekovic, Enric Mocholi, Onno Kranenburg, Paul J. Coffer

“…Summary: In colorectal cancer (CRC), increased numbers of tumor-infiltrating CD4+ regulatory T (Treg) cells correlate with tumor development, immunotherapy failure, and poor prognosis. To assess how CRC tumors directly modulate Treg cell differentiation, we developed an in vitro co-culture system using CD4+ T cells from Foxp3eGFP mice and CRC tumor-derived organoids. …”
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Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53. by Kenneth Y Wertheim, Robert Chisholm, Paul Richmond, Dawn Walker

“…Over half of all high-risk cases are expected to succumb to the disease even after chemotherapy, surgery, and immunotherapy. Although the importance of MYCN amplification in this disease is indisputable, the mechanistic details remain enigmatic. …”
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2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway by Shikai Yan, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai

“…Immune checkpoint blockade (ICB) therapeutics are highly effective in cancer immunotherapy, but gastrointestinal toxicity limited the application. …”
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A generative deep neural network for pan-digestive tract cancer survival analysis by Lekai Xu, Tianjun Lan, Yiqian Huang, Liansheng Wang, Junqi Lin, Xinpeng Song, Hui Tang, Haotian Cao, Hua Chai

“…The following drug analysis suggested Dasatinib and YM155 as potential therapeutic agents for improving the prognosis of patients in pan-DTC immunotherapy, thereby contributing to the enhancement of cancer patient survival. …”
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Metastatic brain tumors: from development to cutting‐edge treatment by Guilong Tanzhu, Liu Chen, Jiaoyang Ning, Wenxiang Xue, Ce Wang, Gang Xiao, Jie Yang, Rongrong Zhou

“…For lung cancer, targeted therapy and immunotherapy have shown efficacy, while in breast cancer, monoclonal antibodies, tyrosine kinase inhibitors, and antibody–drug conjugates are effective in BM. …”
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NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target by Hongbo Huang, Qingwang Hua

“…In general, NEIL3 mediates NSCLC progression and affects sensitivity to immunotherapy and chemotherapy; therefore, it is a potential molecular target for treatment.…”
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Clinical, histopathological and parasitological follow-up of dogs naturally infected by Leishmania infantum before and after miltefosine treatment and associated therapies. by Amábilli de Souza Rosar, Carolina Leite Martins, Álvaro Menin, Carolina Reck, Edmundo Carlos Grisard, Glauber Wagner, Mário Steindel, Patricia Hermes Stoco, Patricia Flavia Quaresma

“…Three dogs were treated exclusively with miltefosine, while eighteen received combination therapy with miltefosine with other treatments such as allopurinol, domperidone and immunotherapy. Skin biopsies were obtained from the abdomen to assess inflammatory responses and to quantify parasite loads using qPCR. …”
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Treatment Patterns and Outcomes Among Patients With Advanced or Recurrent Endometrial Cancer Initiating First-Line Therapy in the United States by Robert L. Coleman, Jamie Garside, Jean Hurteau, Joehl Nguyen, Monica Kobayashi

“…Of the patients who received at least 1 LOT, use of immunotherapy in the second-line setting was more common in the dMMR/MSI-H subgroup. …”
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Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab by Francine Foss, Youn H. Kim, Julia Scarisbrick, Oleg Akilov, Robert Ristuccia, Karen Dwyer, Wende Wu, Martine Bagot

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MAM‐STAT3‐Driven Mitochondrial Ca+2 Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients by Arshad Ahmed Padhiar, Xiaohong Yang, Syed Aqib Ali Zaidi, Zhu Li, Jinqi Liao, Wei Shu, Arif Ali Chishti, Liangge He, Gulzar Alam, Abdullah Faqeer, Ilyas Ali, Shuai Zhang, Ting Wang, Tao Liu, Meiling Zhou, Gang Wang, Yan Zhou, Guangqian Zhou

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Radiomics and radiogenomics in intrahepatic cholangiocarcinoma by A. D. Smirnova, G. G. Karmazanovsky, E. V. Kondratyev, N.  A. Karelskaya, V. N. Galkin, A.  Yu. Popov, B. N. Gurmikov, D. V. Kalinin

“…Correlation of texture features with the expression of immunotherapy target genes KRAS/NRAS/BRAF as well as IDH1/2 mutation was shown. …”
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Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab by Ziping Li, Fujing Zhang, Xianghong Jin, Junling Zhuang

“…Abstract Background Immunotherapy is a significant risk factor for severe COVID-19 in multiple myeloma (MM) patients. …”
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Cancer-associated fibroblasts and their role in tumor progression by M. S. Ermakov, A. A. Nushtaeva, V. A. Richter, O. A. Koval

“…CAFs control tumor angiogenesis, cell motility, tumor immunogenic properties, and the development of resistance to chemo- and immunotherapy. As a result of metabolic adaptation of rapidly growing tumor tissue to the nutrients and oxygen deprivation, the main type of energy production in cells changes from oxidative phosphorylation to anaerobic glycolysis. …”
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Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

“…Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising future for wide applications in cancer immunotherapy and autoimmune disease. The key of clinical application and commercial-scale manufacturing of BsAbs is the amenability to assembly and purification of desired heterodimers. …”
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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets by Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu

“…With the encouraging results of cancer immunotherapy in recent years, more investigation into the impact of glutamine metabolism on immune cell function in the cancer microenvironment could lead to the discovery of new targets and therapeutic approaches. …”
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DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma by Ze Qian, Yifan Jiang, Yacong Wang, Yu Li, Lin Zhang, Xiaofeng Xu, Diyu Chen

“…We also discovered a correlation between ACADS and ICD, suggesting that ACADS is an essential target for immunotherapy in HCC. Graphical Abstract…”
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