Panoptosis – new frontier in research in head neck cancer by Shrikant B. Mali

“…Head and neck squamous cell carcinoma (HNSCC) is a common cancer that can develop resistance to therapeutic approaches, including chemotherapy, targeted therapy, and immunotherapy. PANoptosis, a non-apoptotic cell death mechanism, has been identified as a potential solution. …”
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Induction of Tolerance via the Sublingual Route: Mechanisms and Applications by Philippe Moingeon, Laurent Mascarell

“…The clinical efficacy of sublingual immunotherapy (SLIT) with natural allergen extracts has been established in IgE-dependent respiratory allergies to grass or tree pollens, as well as house dust mites. …”
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Improving Retrieval Performance of Case Based Reasoning Systems by Fuzzy Clustering by F. Saadi, Baghdad Atmani, F. Henni

“…The approach is tested with the publicly available immunotherapy dataset. The results of the experimentations show that the integration of the FCM algorithm in the retrieval step reduces the search space (the large volume of information), resolves the problem of the vagueness of medical information, speeds up the calculation and response time, and increases the search efficiency, which further improves the performance of the retrieval step and, consequently, the CBR system.…”
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Aligning knowledge concepts to whole slide images for precise histopathology image analysis by Weiqin Zhao, Ziyu Guo, Yinshuang Fan, Yuming Jiang, Maximus C. F. Yeung, Lequan Yu

“…In the application of lung cancer subtyping, breast cancer HER2 scoring, and gastric cancer immunotherapy-sensitive subtyping tasks, ConcepPath significantly outperformed previous SOTA methods, which lacked the guidance of human expert knowledge.…”
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Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report by Gosselin-Rousselle Louise, Gaudimier Zoé, Pamelard Pierre-Olivier, Sader Paul, Moizan Hervé

“…Conclusion: While definitive causality between Pembrolizumab and osteonecrosis of the jaw cannot be established with the current evidence, this case adds to the growing body of literature suggesting that immune checkpoint inhibitors may be implicated in the pathogenesis of osteonecrosis of the jaw. As the use of immunotherapy expands in oncology, further research is essential to elucidate this association and provide guidelines.…”
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ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives by Marco Folci, Giacomo Ramponi, Dana Shiffer, Aurora Zumbo, Michele Agosti, Enrico Brunetta

“…PR3-derived PR1 peptide is being studied as an immunotherapy target in leukemia and multiple myeloma. …”
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Ocular Melanoma Metastasizing to Intra-Abdominal Lymph Nodes by David Aranovich, Karen Meir, Michal M. Lotem, Liat Appelbaum, Hadar Merhav

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DNA Vaccination: Using the Patient's Immune System to Overcome Cancer by Georg Eschenburg, Alexander Stermann, Robert Preissner, Hellmuth-Alexander Meyer, Holger N. Lode

“…Along this line, the development of immunotherapy in general and the innovative concept of DNA vaccination in particular may provide a venue to achieve this goal. …”
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Primera parte. Hombre de 45 años con neumonía grave, infección diseminada por citomegalovirus y agammaglobulinemia by Mónica Fernandes Pineda, Andrés F. Zea-Vera

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Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…Nowadays, oncogene-directed therapy and immunotherapy represent the two most promising avenues for patients with metastatic melanoma. …”
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DRG2 as a Biomarker to Enhance the Predictive Efficacy of PD-L1 Immunohistochemistry Assays by Muralidharan Mani, Seong Hee Choi, Hyuk Nam Kwon, Jeong Woo Park

“…PD-L1 immunohistochemistry (IHC) assays are used as a companion diagnostic for immunotherapy with immune checkpoint inhibitors (ICIs). …”
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Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer by Hany E. Marei, Khaled Bedair, Anwarul Hasan, Layla Al-Mansoori, Sara Caratelli, Giuseppe Sconocchia, Alice Gaiba, Carlo Cenciarelli

“…Innovative treatment approaches are desperately needed because treatment resistance brought on by current clinical drugs impedes therapeutic efficacy. The T cell-based immunotherapy known as chimeric antigen receptor (CAR) T cell treatment, which uses the patient’s immune cells to fight cancer, has demonstrated remarkable efficacy in treating hematologic malignancies; nevertheless, the treatment effects in solid tumors, like breast cancer, have not lived up to expectations. …”
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Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment by Eleni Thodou, Maria Befani, George Triantafyllidis, Theodosia Choreftaki, George Kanellis, Nikolaos Giannakoulas

“…It is also the first report highlighting the importance of this novel immunotherapy in the management of refractory Hodgkin lymphoma with breast involvement.…”
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Photodynamic therapy for oral cancer: Mechanisms, efficacy, and clinical applications by Shyamaladevi Babu, Madhan Krishnan

“…Future directions include exploring synergistic combinations of PDT with chemotherapy and immunotherapy, aiming to potentiate therapeutic responses and improve long-term survival rates. …”
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Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.…”
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Intratumoral microbiota, fatty acid metabolism, and tumor microenvironment constitute an unresolved trinity in colon adenocarcinoma by Guangyi Liu, Kun Liu, Lei Ji, Yang Li

“…More importantly, the crosstalk between the three can have a significant impact on prognosis, response to immunotherapy, and drug sensitivity of patients. Pathological image profiling showed that changes in the TME originating from intratumoral microbiota disturbance could be reflected in pathological image features. …”
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Convalescent plasma therapy in severe coronavirus disease-2019: A narrative review by Rasmi Ranjan Sahoo, Kasturi Hazarika, Prashant Bafna, Manesh Manoj, Anupam Wakhlu

“…Passive immunotherapy using whole blood or plasma from recovered patients is a potential therapeutic strategy for infections with no known drug therapy or prophylactic vaccines. …”
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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment by Tian Z, Wang X, Chen S, Guo Z, Di J, Xiang C

“…Zui Tian,* Xudong Wang,* Shuai Chen,* Zijian Guo, Jingkai Di, Chuan Xiang Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan Xiang, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China, Email chuanxiang@sxmu.edu.cnAbstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. …”
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In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? by Carlotta Mattioda, Claudia Voena, Gianluca Ciardelli, Clara Mattu

“…Currently available therapies, including chemotherapy, immunotherapy, and CAR-T cells, are often associated with important side effects and with the development of drug resistance and, consequently, disease relapse. …”
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Dynamics analysis and optimal control of a fractional-order lung cancer model by Xingxiao Wu, Lidong Huang, Shan Zhang, Wenjie Qin

“…Next, by considering surgery and immunotherapy as control measures, we discussed the existence of an optimal solution and derived its expression using the Pontryagin maximum principle. …”
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