Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…In this review, we will discuss the structure and functions of PP2A in T cell differentiation and diseases and therapeutic applications of PP2A-mediated immunotherapy.…”
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Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer by Roberto Eduardo Aguirre Fernández, Miguel Ángel Serra Valdés

“…Current clinical practice guidelines offer treatment models that involve surgery, radiotherapy, chemotherapy, immunotherapy and therapy directed at specific growth receptors, however, genetic and molecular biology aspects are not always taken into account in medical practice. …”
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Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored by Ying Wang, Shuang Sun, Jie Zhu, Li Cui, Hong-Liang Zhang

“…Biomarkers of GBS have been extensively explored and some of them are proved to assist in the clinical diagnosis and in monitoring disease progression as well as in assessing the efficacy of immunotherapy. Herein, we systemically review the literature on biomarkers of GBS, including infection-/immune-/BNB, B-CSF-B, and PNS damage-associated biomarkers, aiming at providing an overview of GBS biomarkers and guiding further investigations. …”
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Cutaneous Squamous Cell Carcinoma with Signet-Ring Cell Component and CDX2 Expression in a Patient Treated with PD-1 Inhibitor: A Case Report of a Common Tumor with Unusual Differe... by Sherehan Zada, Jeremiah Tao, Maria Del Valle Estopinal

“…Our findings suggest a form of acquired SCC cell resistance to immunotherapy that might involve CDX2-related pathways.…”
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Research Advances in Antitumor Mechanism of Evodiamine by Luning Li, Cunxin Zhang, Chen Huang, Xinchen Tian, Wenxue Sun, Shulong Jiang

“…There is growing evidence that evodiamine can inhibit the rapid proliferation of tumor cells, induce cell cycle arrest at a certain phase, increase the incidence of apoptosis, promote autophagy, inhibit microangiogenesis and migration, and regulate immunotherapy. Evodiamine can inhibit Wnt/β-catenin, mTOR, NF-κB, PI3K/AKT, JAK-STAT, and other signaling pathways in various cancer cells, and it can significantly downregulate the expression of many tumor markers, such as VEGF and COX-2. …”
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CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms by Raanan Greenman, Chris J. Weston

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Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block by Alisha Khan, Sana Riaz, Robert Carhart

“…We conclude by recommending a higher degree of caution and awareness among all physicians when treating patients on immunotherapy and a multidisciplinary approach when considering resumption of immune checkpoint inhibitor therapy.…”
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The Role of Immune Defects and Colonization of Staphylococcus aureus in the Pathogenesis of Atopic Dermatitis by Danuta Nowicka, Ewelina Grywalska

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Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier by Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

“…The interaction between cancer-associated fibroblasts (CAFs) and TME influences immune responses, including resistance to immunotherapy. Notably, human papillomavirus-driven HNSCC exhibits distinct DR characteristics that further influence the prognosis. …”
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Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective by Wuzhen Chen, Jingxin Jiang, Wenjie Xia, Jian Huang

“…Based on the truth that TEXs play crucial roles in suppressing the immune system, studies on modification of exosomes as immunotherapy strategies will also be discussed.…”
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Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies by Nidhi Agrawal, S.K. Lanjhiyana, Meenakshi Jaiswal, Mohammad Akbar Siddiqui, Sakshi Gupta

“…Recently, novel strategies including targeted therapy and immunotherapy have emerged as novel possibilities for treating CRC. …”
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Candida Biofilms and the Host: Models and New Concepts for Eradication by Hélène Tournu, Patrick Van Dijck

“…Alternative strategies against biofilms include the lock therapy and immunotherapy approaches, and material coating and improvements. …”
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New Antibody Conjugates in Cancer Therapy by Serengulam V. Govindan, David M. Goldenberg

“…Importantly, the advantages of combining RAIT with radiation sensitizers, with immunotherapy, or a drug conjugate targeting a different antigen are being studied clinically and preclinically. …”
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The Use of Bacteria in Cancer Treatment: A Review from the Perspective of Cellular Microbiology by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…The therapeutic role of bacteria has gained attention since the known methods such as radiation, chemotherapy, and immunotherapy have got drawbacks. Bacteria have demonstrated a favorable impact in treating cancer through eradication of tumors. …”
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A Case of Heterotopic Ossification in Papillary Renal Cell Carcinoma Type 2 by Facundo Davaro, Elizabeth Davaro, Amna Qureshi, Lindsay Lombardo

“…These entities carry with them unique prognoses and necessitate treatment with specific immunotherapy agents should advanced disease be uncovered. …”
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Strategies to Overcome Antileishmanial Drugs Unresponsiveness by Shyam Sundar, Anup Singh, Om Prakash Singh

“…In the current review, we highlight various steps which could be implemented to halt the increasing unresponsiveness of drugs such as monitoring of therapy in the form of rational dosing and duration of treatment, understanding the mechanism of action of the drugs and drug resistance, identification of markers of resistance, distribution of drugs free of cost, evolution of effective combination therapy and immunotherapy, and proper management of HIV/VL coinfection and post-kala-azar dermal leishmaniasis (PKDL). …”
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Bilateral Asynchronous Renal Cell Carcinoma with Metastatic Involvement of the Tongue by Naseem Ghazali, Charlotte Davis, A. W. Barrett, John V. Tighe

“…Due to end-stage primary pulmonary malignancy, and poor function of the remaining kidney, immunotherapy was unsuitable. Palliative local resection of the lingual metastasis alleviated functional difficulties and was preventative against airway obstruction, but the patient died five months later.…”
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Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023–2038 by Zixing Wang, Wei Han, Ran Fei, Yaoda Hu, Fang Xue, Wentao Gu, Cuihong Yang, Yubing Shen, Luwen Zhang, Jingmei Jiang

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RNA N6‐Methyladenosine‐Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN‐γ Signaling in Gastric Cancer by Dongjun Jang, Chanwoong Hwa, Seoyeon Kim, Jaeik Oh, Seungjae Shin, Soo‐Jin Lee, Jiwon Kim, Sang Eun Lee, Yoojin Yang, Dohee Kim, Seoho Lee, Hae Rim Jung, Yumi Oh, Kyunggon Kim, Hye Seung Lee, Joon‐Yong An, Sung‐Yup Cho

“…Abstract Immunotherapy holds potential as a treatment for gastric cancer (GC), though immune checkpoint inhibitor (ICI) resistance remains an obstacle. …”
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CT45A1‐mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell‐in‐cell structure, potentiating the progression of microsatellite... by Hao‐Wei Teng, Hsiang‐Yueh Huang, Chun‐Chi Lin, Yuh‐Ching Twu, Wen‐Hao Yang, Wen‐Chun Lin, Hsin‐Yi Lan, Yen‐Yu Lin, Wei‐Lun Hwang

“…Patients with microsatellite instability‐high (MSI‐H) colorectal cancer (CRC) have high tumor mutation burden and tumor immunogenicity, exhibiting a higher response rate to immunotherapy and better survival. However, a portion of MSI‐H CRC patients still experience adverse disease outcomes. …”
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