Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker by Yaoting Zhang, Sultan Kadasah, Jiaheng Xie, Dongsheng Gu

“…Our further investigation of the coexpression pattern of HNSCC could provide a reference for drug resistance and immunotherapy studies.…”
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A Potential Concept In The Management of Tumors With Modulation of Prostaglandin, Nitric Oxide and Antioxidants by Noori S. Al-Waili

“…Evidence supports the efficacy of PG inhibition in malignancies, and the concept of PG inhibition, NO modulation, anti-oxidants, immunotherapy with antibody or immune cells, and anti-inflammatory agents when used in the prevention and management of malignancies are discussed.…”
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Modulation of Immunoregulatory Properties of Mesenchymal Stromal Cells by Toll-Like Receptors: Potential Applications on GVHD by Bruno Sangiorgi, Rodrigo Alexandre Panepucci

“…The capacity to enhance the immunosuppressive phenotype of MSCs through TLRs stimulation might be properly elucidated in order to improve the MSC-based immunotherapy against GVHD.…”
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Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 by Semi Kim, Jung Weon Lee

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Progressive loss of upper limb function as a presenting feature of glenohumoral metastasis from a primary tongue malignancy by Adarsh Kudva, Vasantha Dhara, Asmita Unadkat

“…Palliative chemo or radio-therapy, immunotherapy or surgical treatment are indicated depending on the site, number of bony metastases and performance score of the patient; however with guarded prognosis. …”
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Oral manifestation associated with avelumab by Kevin Chung, Annu Singh, Joseph M. Huryn, Cherry L. Estilo

“…Emerging immunotherapies are becoming more prominent in treating various cancers. …”
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Toll-Like Receptor 4 Activation in Cancer Progression and Therapy by Alja Oblak, Roman Jerala

“…Cancer immunotherapy has been the focus of intense research since the late 19th century when Coley observed that bacterial components can contribute to cancer regression by eliciting an antitumor immune response. …”
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Durable Clinical Benefit after Dual Checkpoint Inhibition and Single-agent Nivolumab Following Pembrolizumab Failure in Mismatch Repair-deficient Colon Cancer by Yat-Fung Chow, Hou-Hsuan Cheng, Ming-Huang Chen

“…Immunotherapy with immune checkpoint inhibitors (ICIs) is beneficial in treating tumors with high microsatellite instability or DNA mismatch repair deficiency (dMMR) tumors. …”
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Case report: Primary cardiac undifferentiated sarcoma complicated by esophagus stenosis by Yuxin Ge, Xiaopan Lv, Rui Zhang, Dongxiao Hao, Guifei Si, Yuquan Li, Xuemin Yuan, Xiuping Li

“…Following postoperative treatment that included radiotherapy and immunotherapy, the patient developed esophagus stenosis.…”
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David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma by Te-Lin Hsu, San-Chi Chen

“…Although the efficacy of vinorelbine is modest, some studies suggest its synergistic effect with immunotherapy. In our case report, a patient with metastatic AS received frontline paclitaxel followed by pembrolizumab, but this treatment failed. …”
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The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis by Beibei Wu, Beibei Wu, Beibei Wu, Ding Luo, Ding Luo, Xuejie Wang, Xuejie Wang, Chen Qiao, Chen Qiao, Rui Li, Jian Liu, Jian Liu

“…Leading contributors include the United States, the National Cancer Institute, the journal Cancer Immunology Immunotherapy, and researcher Steven A. Rosenberg. Other prominent contributors include China, the National Institutes of Health, researcher Roberto Salgado, and the Journal of Immunology. …”
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Construction of a novel cuproptosis-related gene signature and integrative analyses in cholangiocarcinoma by Liye Wang, Pan Li, Shuai Gong, Lina Pang, Mingyu Li, Chi Zhang, Shengli Zhang, Xiaoke Zhang, Guozhong Jiang, Wei He

“…The comprehensive results showed that a low-risk score was correlated with metabolism-related pathways, high infiltration of CD8 T cells, B cells, and M1 macrophages, active immunity and less aggressive phenotypes, high chemotherapeutic sensitivity, and more benefit from immunotherapy. In contrast, a high-risk score was associated with cancer and metastasis-related pathways, high infiltration of M2 macrophages, high expression of immune checkpoint genes, suppressive immunity and more aggressive phenotypes, and less benefit from chemotherapeutic and immunotherapy. …”
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A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Kaiwen Tian, Jiayi Zeng, Jiumin Liu, Yuming Yu

“…Identifying immune-related lncRNAs and constructing a model would probably provide new insights into biomarkers and immunotherapy for ccRCC and aid in the prognosis prediction. …”
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Construction of an anaplastic thyroid cancer stratification signature to guide immune therapy selection and validation of the pivotal gene HLF through in vitro experiments by Li Pengping, Yin Kexin, Xie Yuwei, Sun Ke, Li Rongguo, Wang Zhenyu, Jin Haigang, Wang Shaowen, Huang Yuqing

“…Our study aims to identify ATC patients who might bene t from immunotherapy.MethodsOur study uses multiple algorithms by R4.2.0, and gene expression and clinical data are collected from TCGA, GEO and local cohort. …”
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METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer by Fang Wang, Chen Yang, Fang Zheng, Yang Yan, Guifang Li, Yanyan Feng, Hejia Xu, Zilong He, Dongyan Cai, Hairong Sun, Xiaowei Qi, Yong Mao

“…Abstract Background Colorectal cancer (CRC) is characterized by poor responsiveness to immune evasion and immunotherapy. RNA 7-methylguanine (m7G) modification plays a key role in tumorigenesis. …”
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Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation by Yu Tang, Ruizhi Zhang, Gan Mao, Chong Li, Yisong Gao, Xuebing Zhou, Wenxiang Nie, Tianyu Song, Suao Liu, Kaixiong Tao, Peng Zhang, Wei Li

“…Additionally, we aimed to identify the clinical potential of combining epigenetic inhibitors with immune checkpoint inhibitors to improve the efficacy of immunotherapy for gastric cancer. Methods The correlation between ARID1A gene expression and gastric cancer patient survival was analyzed using the GEO dataset GSE62254. …”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…In addition, we found that CYFIP2 expression values in pancreatic cancer were positively correlated with the expression of most immune cells, especially CD8 + T Cells, and significantly negatively correlated with macrophages M0, and negatively correlated with the metastatic and invasive ability of pancreatic cancer cells, which may provide new strategies and ideas for pancreatic cancer immunotherapy.…”
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Endocrine treatment mechanisms in triple-positive breast cancer: from targeted therapies to advances in precision medicine by Xiu Yang, Daxin Yang, Xue Qi, Xiujuan Luo, Guangmei Zhang

“…Current strategies in TPBC treatment, including endocrine and HER2-targeted therapies, are explored alongside emerging approaches such as immunotherapy and CRISPR/Cas9 gene editing. Additionally, we discuss the tumor microenvironment (TME) and its role in treatment resistance, highlighting promising avenues for intervention through combination therapies and predictive biomarkers. …”
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Posttranslational Modifications and the Immunogenicity of Biotherapeutics by Roy Jefferis

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Uncommon Cause of Psychotic Behavior in a 9-Year-Old Girl: A Case Report by Willemina K. Van Putten, Said Hachimi-Idrissi, Anna Jansen, Viola Van Gorp, Luc Huyghens

“…Prompt recognition of this disorder followed by immunotherapy results in full neurological recovery.…”
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