A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy by Yiming Xu, Yuan Wu, Xinjie Zheng, Dongxue Wang, Hangqi Ni, Weiyu Chen, Kai Wang

“…Among all, emerging strategies targeting cancer metabolism have shown great potency in treating cancers with immunotherapy. Here, alteration in glucose and copper metabolisms is found to synergistically regulate PD‐L1 expression in lung cancer cells. …”
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Identification of Hepatocellular Carcinoma Subtypes Based on Global Gene Expression Profiling to Predict the Prognosis and Potential Therapeutic Drugs by Cunzhen Zhang, Jiyao Wang, Lin Jia, Qiang Wen, Na Gao, Hailing Qiao

“…TIDE was employed to predict the patient response to immunotherapy. Finally, drug sensitivity was analyzed using the oncoPredict algorithm. …”
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Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity by Nilberto Dias de Araújo, Fábio Magalhães Gama, Mateus de Souza Barros, Thaís Lohana Pereira Ribeiro, Fabíola Silva Alves, Lilyane Amorim Xabregas, Andréa Monteiro Tarragô, Adriana Malheiro, Allyson Guimarães Costa

“…Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). …”
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Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications by Tian-Hang Yu, Yan-Yu Ding, Yan-Yu Ding, Si-Guo Zhao, Jie-Hui Zhao, Yu Gu, Dong-Hui Chen, Fang Zhang, Wen-Ming Hong, Wen-Ming Hong

“…An in-depth examination of DAPK1’s specific mechanisms in glioblastoma could elucidate its role in immunotherapy response. Targeting the DAPK1 gene may offer therapeutic benefits for glioma patients.…”
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High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models by Hak Su Kim, Seung-hyun Kwon, Ok Kyung Choi, Taekyu Lim, Taekyu Lim

“…This study aimed to elucidate the effects of high-dose AA on anti-PD1 immunotherapy in NSCLC.MethodsThe combined effects of high-dose AA and anti-PD1 were investigated using a coculture model of H460 cells and CD8+ T cells and an LLC1 lung cancer syngeneic mouse model. …”
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Reliability of mpMRI in diagnosing cancer prostate following intravesical BCG for bladder cancer by Arjun Pon Avudaiappan, Pushan Prabhakar, Rachel Siretskiy, Andrew Renshaw, Ahmed Eldefrawy, Murugesan Manoharan

“…Abstract Background Detecting carcinoma prostate (CaP) after intravesical Bacillus Calmette Guerin (BCG) immunotherapy for non‐muscle invasive bladder cancer (NMIBC) poses diagnostic challenges. …”
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SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells by Melissa Bernhardt, Anne Rech, Marion Berthold, Melina Lappe, Jan-Niklas Herbel, Florian Erhard, Annette Paschen, Bastian Schilling, Bastian Schilling, Andreas Schlosser

“…This finally led to the discovery of new potential targets for cancer immunotherapy.…”
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Neo-BCV: A Novel Bacterial Liquid Complex Vaccine for Enhancing Dendritic Cell-Mediated Immune Responses Against Lung Cancer by Zilong Zhu, Zhuze Chu, Fei Fei, Chenxi Wu, Zhengyue Fei, Yuxia Sun, Yun Chen, Peihua Lu

“…Background: In the past decade, immunotherapy has become a major choice for the treatment of lung cancer, yet its therapeutic efficacy is still relatively limited due to the various immune escape mechanisms of tumors. …”
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Redox-dependent purine degradation triggers postnatal loss of cardiac regeneration potential by Yuichi Saito, Yuki Sugiura, Akane Sakaguchi, Tai Sada, Chihiro Nishiyama, Rae Maeda, Mari Kaneko, Hiroshi Kiyonari, Wataru Kimura

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Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…Further, patients with high-risk scores had a lower likelihood of benefiting from immunotherapy. Conclusion Using bulk RNA-seq and single-cell RNA-seq, we analyzed myeloid heterogeneity at the single-cell level, and we developed an 8-gene model that predicts survival outcomes and immunotherapy response in PADC.…”
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RETRACTED ARTICLE: Construction and validation of a machine learning-based immune-related prognostic model for glioma by Qi Mao, Zhi Qiao, Qiang Wang, Wei Zhao, Haitao Ju

“…These findings provide new perspectives for glioma prognosis assessment and immunotherapy.…”
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Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and... by Yulin Shi, Yang Yu, Jiahan Zhao, Linan Huang, Qingyang Wang, Qi Sun, Lijuan Liu, Changgang Sun

“…Although improving TEX and enhancing effector function are promising strategies for strengthening immunotherapy, their role in the pathogenesis of TNBC remains unclear. …”
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Identification of a novel immunogenic cell death-related classifier to predict prognosis and optimize precision treatment in hepatocellular carcinoma by Dongjing Zhang, Bingyun Lu, Qianqian Ma, Wen Xu, Qi Zhang, Zhiqi Xiao, Yuanheng Li, Ren Chen, An-jiang Wang

“…In contrast, low ICD score corresponded to abundant immune cell infiltration, high sensitivity to immunotherapy and a positive prognosis, indicating an “immune-hot” phenotype. …”
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Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer by Chien-Tzu Huang*, Jeng-Shiun Du

“…However, the role of immunotherapy in the neoadjuvant setting remains uncertain. …”
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T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications by Claudio Fozza, Maurizio Longinotti

“…We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL.…”
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Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report by Miguel Soto Ontoso, Ruben A. Piernas González, Isabel Ramírez Martínez, José Miguel Meca García

“…We report one case that highlights the variability of clinical manifestations, which in the absence of antibodies was treated with immunotherapy with good response. Conclusion. In places where there is no antibody measurement, or when its measurement is negative, the clinical suspicion supported by CSF studies, magnetic resonance imaging, and electroencephalographic recording, should guide us to start immunotherapeutic treatment early. …”
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Immunotherapeutic Strategies for Alzheimer's Disease Treatment by Beka Solomon

“…Active and/or passive immunization against the amyloid-β peptide has been proposed as a method for preventing and/or treating AD. Immunotherapy represents fascinating ways to test the amyloid hypothesis and offers genuine opportunities for AD treatment, but requires careful antigen and antibody selection to maximize efficacy and minimize adverse events.…”
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Interactions between the tumor microbiota and breast cancer by Hua Guo

“…Gut microbes and their metabolites influence the development of breast cancer by regulating the tumor immune response, estrogen metabolism, chemotherapy, and immunotherapy effects. It was previously thought that there were no microorganisms in breast tissue, but it is now thought that there are microorganisms in breast cancer that can affect the outcome of the disease. …”
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Editorial: Community series in BCR signaling and B cell activation, volume 2 by Wenxia Song, Tae Jin Kim, Tae Jin Kim, Wanli Liu, Wanli Liu

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Intestinal Immune Imbalance is an Alarm in the Development of IBD by Chunli Hu, Shengtao Liao, Lin Lv, Chuanfei Li, Zhechuan Mei

“…These events indicate that intestinal immune imbalance is an alarm for IBD development, further opening new possibilities for the unprecedented development of immunotherapy for IBD.…”
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