Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer by Jingmin Che, Bo Chen, Xusheng Wang, Baoe Liu, Cuixiang Xu, Huxia Wang, Jingying Sun, Qing Feng, Xiangrong Zhao, Zhangjun Song

“…Conclusion This study provides new theoretical evidence and potential therapeutic targets for the immunotherapy strategies of TNBC, holding significant clinical application value.…”
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Characteristics, treatment patterns, and biomarker testing of patients with advanced RET fusion-positive non-small cell lung cancer in a real-world multi-country observational stud... by Urpo Kiiskinen, Grace Segall, Hollie Bailey, Cameron Forshaw, Tarun Puri

“…Comparisons between the two cohorts showed similar proportions of patients treated with chemotherapy (± immunotherapy), but less use of immunotherapy only or targeted therapy in the RET fusion-positive cohort.ConclusionsResults of this real-world study provide insights into clinical characteristics, biomarker testing, and treatment patterns of patients with RET fusion-positive aNSCLC and highlight the need for awareness and education to increase RET testing with the intent to treat with selective RET inhibitors when appropriate to optimize outcomes for patients.…”
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Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas by Børre Fevang, Unn Merete Fagerli, Hanne Sorte, Harald Aarset, Håkon Hov, Marit Langmyr, Thomas Morten Keil, Ellen Bjørge, Pål Aukrust, Asbjørg Stray-Pedersen, Tobias Gedde-Dahl

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Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping by Shansong Huang, Huiying Wang, Jiaqing Cao, Qiang Pang

“…ITLN1 could be a target for enhancing immunotherapy response in CRC.…”
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Pulmonary enteric adenocarcinoma with progression disease after second - line therapy: a case report by Ya Guo, Bin Zhang, Heng Zhang, Yunbin Gao, Haibo Zhao, Pei Jiang, Qing-Qing Yu

“…The results suggest that standard first-line therapies (immunotherapy plus chemotherapy) and colorectal cancer regimens may have a relatively limited impact on survival in KRAS-driver positive advanced PEAC.…”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

“…The difference in the tumor immune microenvironment between the low- and high-risk populations may be the reason for the resistance to immunotherapy in some patients.…”
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Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention by Martin R. Jadus, Josephine Natividad, Anthony Mai, Yi Ouyang, Nils Lambrecht, Sandor Szabo, Lisheng Ge, Neil Hoa, Maria G. Dacosta-Iyer

“…We also review the history of immunotherapy directed towards lung cancers.…”
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Redefining bladder cancer treatment: innovations in overcoming drug resistance and immune evasion by Peng Huang, Jie Wang, Zongze Yu, Jiaan Lu, Zhou Sun, Zhigui Chen

“…Further, it discusses the challenges and mechanisms of resistance to immunotherapy, including those involving immune checkpoint inhibitors. …”
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T cell receptor signaling pathway subgroups and construction of a novel prognostic model in osteosarcoma by Huan Xu, Huimin Tao

“…Our findings may bring a new insight into the immunotherapy for OS patients.…”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…Conclusions. Immunotherapy using checkpoint inhibitors can serve as a novel treatment option for patients in the clinical predicament of having a solid organ transplant and simultaneous metastatic malignancy. …”
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Mast cells: key players in digestive system tumors and their interactions with immune cells by Feihong Shu, Jie Yu, Youjia Liu, Fang Wang, Guoyou Gou, Min Wen, Chen Luo, Xianmin Lu, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie

“…The aim is to propose new strategies for the immunotherapy of digestive system tumors by targeting mast cells.…”
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Neoadjuvant programmed death ligand-1 with chemotherapy versus chemotherapy alone for limited-stage small-cell lung cancer: a retrospective study by Zhi Yang, Yan-qing Wang, Xiujun Chang

“…There were no perioperative deaths.ConclusionsNeoadjuvant immunotherapy shows lower toxicity and fewer perioperative complications. …”
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Autoimmune pancerebellitis as an immune-related adverse event: an illustrative case by D. Valančius, I. Zagorskienė, A. Klimašauskienė

“…Unfortunately, every effective treatment has its side effects, and immunotherapy is no exception. In this article, the authors present an illustrative and rare clinical case of a patient who developed autoimmune pancerebellitis during therapy with immune checkpoint inhibitors. …”
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Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

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Ferroptosis and its relationship with cancer by Chuanchao Su, Yiwen Xue, Siyu Fan, Xin Sun, Qian Si, Zhen Gu, Jingfei Wang, Runzhi Deng

“…The main molecular processes of ferroptosis discovered yet will be presented here, along with the approaches in which it interacts with tumour-associated signaling pathways and its uses in systemic therapy, radiation therapy, and immunotherapy managing tumors.…”
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A case of subcutaneous metastatic malignant melanoma of the left medial ankle: a case report and review of literature by Lauren Workman, Lauren Fang, Martina Blazevic, Joanna Chen, Richard Simman

“…Following left inguinal lymph node dissection, the patient received adjuvant immunotherapy and radiation to the left inguinal area. …”
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PARP inhibitors in the treatment of Pancreatic Cancer - A Review of literature by Jagoda Niewiadomska, Wiktor Grela, Daria Furtak, Dawid Tulej, Paulina Głogowska, Alicja Dziedzic, Natalia Gniaź, Dominika Marciniuk, Natalia Marko, Aleksandra Górska

“…The primary therapy for these cancers is surgery; chemotherapy, radiation therapy, hormone therapy, or immunotherapy are also used.  More and better treatments are being sought for this disease. …”
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Identifying MTHFD1 and LGALS4 as Potential Therapeutic Targets in Prostate Cancer Through Multi-Omics Mendelian Randomization Analysis by Huan Han, Hanwen Su, Zhihua Lv, Chengliang Zhu, Jingtao Huang

“…TIDE analysis was utilized to investigate gene immunotherapy response. Single-cell RNA sequencing data from the GSE176031 dataset were used to investigate the gene expression patterns. …”
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Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination by Tian He, Yating Li, Weiqi Li, Muqing Zhang, Guishuan Wang, Peng Zhou, Guoqi Song, Wenqing Li

“…A next-generation STING agonist MSA-2 is a promising tumor immunotherapy strategy. However, the methods for improving the anti-tumor efficacy of MSA-2 are a lot of effort. …”
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STAT3 Expression and Its Correlation with PD-L1 Expression in Non-Hodgkin’s Lymphoma and Hodgkin’s Lymphoma at Dr. Saiful Anwar Regional Public Hospital in Malang, Indonesian Popul... by Ailen Oktaviana Hambalie, Eviana Norahmawati, Agustina Tri Endharti, Diah Prabawati Retnani, Nayla Rahmadiani

“…Despite the availability of many therapeutic modalities for lymphoma, such as Brentuximab vedotin, Nivolumab, and Pembrolizumab, it is still necessary to identify appropriate strategies with minimal side effects. Immunotherapy is a promising approach, exemplified by targeting JAK/STAT3 signaling, which can inhibit tumor growth and enhance antitumor immune responses. …”
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