Shedding new light on atherosclerosis therapeutics: Nanomedicines targeting atherosclerotic immune microenvironment by Zhiyue Wang, Jie Sheng, Guangming Lu, Longjiang Zhang

“…AIME is characterized by persistent inflammatory responses, shifted immunometabolism, and the formation of adventitial neuroimmune cardiovascular interfaces, all of which are regarded as prospective targets for AS immunotherapy. Recently, the advent of nanotechnology has advanced AS immunotherapy targeting the AIME. …”
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A Cell Differentiation Trajectory-Related Signature for Predicting the Prognosis of Lung Adenocarcinoma by Fan Yang, Yan Zhao, Xiaohan Huang, Jin Zhang, Ting Zhang

“…Then, the consensus clustering analysis was carried out on TCGA-LUAD samples, and the GSEA analysis was performed, then the differences on the expression levels of immune checkpoint genes and immunotherapy response were compared among clusters. …”
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MHC Class 1 and PDL-1 Status of Primary Tumor and Lymph Node Metastatic Tumor Tissue in Gastric Cancers by Ibrahim Halil Erdogdu

“…Despite the use of VEGF-, EGFR-, and HER2-targeting agents, prognosis is still poor in advanced gastric cancer. Although cancer immunotherapy responds well in some patients, clinical use is limited due to unanswered patients. …”
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CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells by Lin Xu, Chunhong Wang, Zhenke Wen, Ya Zhou, Zhongmin Liu, Yongjie Liang, Zengguang Xu, Tao Ren

“…Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. …”
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Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice by Jeannette Lo, Chang-Qing Xia, Ruihua Peng, Michael J. Clare-Salzler

“…Dendritic cell (DC) immunotherapy has been effective for prevention of type 1 diabetes (T1D) in NOD mice but fails to protect if initiated after active autoimmunity. …”
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Evaluation of the microenvironment formed by interferon-β by Mai Yamagishi, Mai Yamagishi, Yutaka Hori, Nobutake Suzuki, Nobutake Suzuki, Yu Peng, Yu Peng, Yoshie Harada, Takashi Funatsu, Osamu Ohara, Yoshitaka Shirasaki, Yoshitaka Shirasaki

“…Our objective is to contribute to the basic understanding of the interplay between immune cells and their microenvironment, with particular relevance to implications for immunotherapy and disease progression.…”
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Movement disorders in autoimmune encephalitis: Clinical spectrum, prognosis, and outcomes from an Indian cohort by Shreyashi Jha, Netravathi M, Vikram Venkappayya Holla, Nitish Kamble, Anita Mahadevan, Pramod Kumar Pal

“…Parkinsonism and FBDS were commonly observed in patients above 45 years of age (P < 0.001). Good response to immunotherapy was observed in 91.4%. Multivariate regression analysis demonstrated that preceding Japanese encephalitis infection, ICU stay, and delay in immunotherapy were poor prognostic factors. …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Conclusion. Anti-PD-1 immunotherapy is effective in cancers refractory to standard chemotherapy. …”
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Identification of Crotonylation Metabolism Signature Predicting Overall Survival for Clear Cell Renal Cell Carcinoma by Jie Zheng, Yingqing Liu, Kai Wei, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

“…Background. Immunotherapy shows promise in treating cancer by leveraging the immune system to combat cancer cells. …”
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Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma by Zhengyan Li, Wei Chen, Shu Yao, Zuxiang Peng, Hongming Liu, Yongliang Tang, Yi Feng

“…However, mitophagy did not seem to affect the effectiveness of immunotherapy.ConclusionThis study provides evidence that mitophagy within the HCC TME modulates intercellular communication, influencing tumor progression and patient prognosis. …”
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A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity by Lanlin Zhang, Jiangyuan Du, Qian Song, Chufan Zhang, Xianghua Wu

“…Dendritic cell- (DC-) based vaccination has emerged as a promising antitumour immunotherapy. However, overcoming immune tolerance and immunosuppression in the tumour microenvironment (TME) is still a great challenge. …”
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Exploring Unique Extracellular Vesicles Associated Signatures: Prognostic Insights, Immune Microenvironment Dynamics, and Therapeutic Responses in Pancreatic Adenocarcinoma by Kai Nan, Ming Zhang, Zilong Geng, Yuankai Zhang, Lin Liu, Zhi Yang, Peng Xu

“…Specifically, elevated expression of LINC00996 correlated positively with immune infiltration and enhanced response to immunotherapy. Conversely, heightened expression of TRHED-AS1 was associated with compromised immune cell infiltration and diminished responsiveness to immunotherapy. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.…”
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Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis by Aldona Pietrzak, Ewelina Grywalska, Mateusz Socha, Jacek Roliński, Kinga Franciszkiewicz-Pietrzak, Lidia Rudnicka, Marcin Rudzki, Dorota Krasowska

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Hepatic sinusoidal obstruction syndrome (SOS) associated with checkpoint inhibitor therapy by Marianna Litterio, Nicole Marchetti, Francesco Carubbi, Marianna Tudini, Luciano Mutti, Claudio Ferri

“…We present the case of a patient with metastatic lung adenocarcinoma treated with the ICI pembrolizumab who developed SOS with marked portal hypertension as a rare severe, toxic side effect of immunotherapy. This report highlights the importance of considering SOS in patients who develop liver dysfunction and/or portal hypertension during or after immunotherapy for neoplastic disease. …”
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Proceedings of clinical trials on bile tract cancer by XIONG Yichen, YANG Ziyi, SANG Yuer, GONG Wei

“…SAGC and SPINE studies showed that immunotherapy combined with chemotherapy or other targeted therapeutics may yield better survival benefit. …”
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Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4 by Zheng-Cai Jia, Bing Ni, Ze-Min Huang, Yi Tian, Jun Tang, Jing-Xue Wang, Xiao-Lan Fu, Yu-Zhang Wu

“…MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials. MAGE-A4 antigen is extensively expressed in various histological types of tumors, so it represents an attractive target for tumor immunotherapy. …”
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Development and preliminary validation of five miRNAs for lung adenocarcinoma prognostic model associated with immune infiltration by Huanzhang Yang, Jingli Hua, Yanxia Han, Dong Chang, Wenlong Zheng

“…Abstract Our aim was to investigate the potential value of immune-related miRNA signaling in predicting clinical prognosis and immunotherapy. We first identified immune-related miRNAs in lung adenocarcinoma (LUAD), and then constructed a miRNA-based risk model by lasso regression modeling. …”
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IGF2BP2 Shapes the Tumor Microenvironment by Regulating Monocyte and Macrophage Recruitment in Bladder Cancer by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Lizhao Wang, Quanpeng Qiu, Rundong Song, Yuanchun Pu, Yuanquan Zhang, Nan Mei, Mengzhao Zhang, Jinhai Fan

“…ABSTRACT Background Immunotherapy has shown promise for bladder cancer (BC) treatment but is effective only in a subset of patients. …”
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Anti-LAG-3 antibody LBL-007 plus anti-PD-1 antibody toripalimab in advanced nasopharyngeal carcinoma and other solid tumors: an open-label, multicenter, phase Ib/II trial by Gang Chen, Dong-Chen Sun, Yi Ba, Ya-Xiong Zhang, Ting Zhou, Yuan-Yuan Zhao, Hong-Yun Zhao, Wen-Feng Fang, Yan Huang, Zhen Wang, Chao Deng, De-Sheng Hu, Wei Wang, Jin-Guan Lin, Gui-Ling Li, Su-Xia Luo, Zhi-Chao Fu, Hai-Sheng Zhu, Hui-Li Wang, Sheng-Li Cai, Xiao-Qiang Kang, Li Zhang, Yun-Peng Yang

“…For other tumors, ORRs were 15.8% in immunotherapy-naive patients and 3.7% in immunotherapy-treated patients. …”
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