Screening of necroptosis-related genes and evaluating the prognostic capacity, clinical value, and the effect of their copy number variations in acute myeloid leukemia by Dake Wen, Ru Yan, Lin Zhang, Haoyang Zhang, Xuyang Chen, Jian Zhou

“…Single-sample gene set enrichment analysis (ssGSEA) was utilized to calculate correlations between the hub-NRDEGs and immune cells. CNV analysis of the hub-NRDEGs was carried out on the TCGA-LAML datasets from the TCGA database. …”
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Alleviating symptoms of paediatric acute rhinosinusitis and acute otitis media with otorrhea using nasal-spraying Bacillus probiotics: a randomized controlled trial by Thanh Huu Khieu, Dung Phuong Le, Binh Thanh Nguyen, Binh Thanh Ngo, Hong Thi Chu, Duc Minh Truong, Hung Minh Nguyen, Anh Hoa Nguyen, Tung Dinh Pham, Anh Thi Van Nguyen

“…These results suggest that nasal-spray Bacillus spore probiotics, with their ability to reduce bacterial load and modulate immune responses, provide a cost-effective and safe solution for alleviating symptoms of both ARS and AOM in children. …”
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Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease... by Georgios Filippou, Antonella Adinolfi, Emilio Filippucci, Nicola Dalbeth, Robert Terkeltaub, Tristan Pascart, Edoardo Cipolletta, Silvia Sirotti, Charlotte Jauffret, Sara Tedeschi, Daniele Cirillo, Luca Ingrao, Alessandro Lucia

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Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection by Ruamviboonsuk V, Kongwattananon W, Chuaypen N

“…Varis Ruamviboonsuk,1,2 Wijak Kongwattananon,1,3 Natthaya Chuaypen4 1Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 2Medical Science Program, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 3Center of Excellence in Retina, Department of Ophthalmology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 4Metabolic Diseases in Gut and Urinary System Research Unit (MeDGURU), Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCorrespondence: Wijak Kongwattananon, Center of Excellence in Retina, Department of Ophthalmology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathum Wan, Bangkok, 10330, Thailand, Tel +662 256 4000, Email wijak.k@chula.ac.thPurpose: Intravitreal brolucizumab, approved for neovascular age-related macular degeneration (nAMD), may trigger immune responses leading to intraocular inflammation (IOI) by increasing pro-inflammatory cytokines. …”
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Integration of clinical, pathological, radiological, and transcriptomic data improves prediction for first-line immunotherapy outcome in metastatic non-small cell lung cancer by Nicolas Captier, Marvin Lerousseau, Fanny Orlhac, Narinée Hovhannisyan-Baghdasarian, Marie Luporsi, Erwin Woff, Sarah Lagha, Paulette Salamoun Feghali, Christine Lonjou, Clément Beaulaton, Andrei Zinovyev, Hélène Salmon, Thomas Walter, Irène Buvat, Nicolas Girard, Emmanuel Barillot

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Molecular cytogenetic characteristics of new spring bread wheat introgressive lines resistant to stem rust by O. A. Baranova, I. G. Adonina, S. N. Sibikeev

“…Evaluation of introgression lines in the field for resistance to the Ug99 race (TTKSK) showed that four lines were immune, two were resistant, three were moderately resistant, and one had an intermediate type of response to infection. …”
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Examining the Prevalence and Associated Factors of Sexually Transmitted Infections in People Living With HIV/AIDS at a Community Health Center in Bandung City, Indonesia by Nuraeni S, Alfian SD, Puspitasari IM

“…Sani Nuraeni,1,* Sofa Dewi Alfian,2,3 Irma Melyani Puspitasari2,3,* 1Master of Pharmacy Program, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 3Center of Excellence for Pharmaceutical Care Innovation (PHARCI), Universitas Padjajdjaran, Sumedang, Indonesia*These authors contributed equally to this workCorrespondence: Irma Melyani Puspitasari, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia, Tel +62 22 84288888 Ext 3510, Email irma.melyani@unpad.ac.idPurpose: This study aims to investigate the prevalence of sexually transmitted infections (STIs) and associated factors among people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) (PLWHA) registered in a community health center (CHC) with HIV/AIDS support and treatment services in Indonesia.Methods: A cross-sectional study that included all PLWHA data from medical records registered in a CHC with HIV/AIDS support and treatment services was conducted in Bandung City, Indonesia, between March 2019 and March 2024. …”
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Association between colorectal cancer and arthritis among Americans in 2005–2016 by Zhongbo Hou, Niping Qin, Yanlin He, Jiang Chen, Yibo Cao, Wei Xie, Tianbao Xiao

“…Some studies have found that arthritis could reduce the risk of CRC through inflammatory immune mediation. However, there have been no reports on whether arthritis is related to CRC. …”
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Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…Numerous potential pathophysiological mechanisms have been discussed, including (1) an indirect role of infectious agents (i.e. a role of infections located distant from the eye, mainly through their interactions with the immune system) and (2) a direct role of some infectious agents implying potential infection of various cells types within AMD-related tissues. …”
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Characterisation of EfbA from the Endodontic Pathogen Enterococcus faecalis and Prediction of Immunodominant EfbA Epitope Peptides: An In-vitro and In-silico Study by Dev Arora, AS Smiline Girija, J Vijayashree Priyadharsini

“…Conclusion: Among the two epitopes, LLLSAHPSY was identified as the most significant immune-dominant epitope predicted, which needs to be further evaluated for vaccine synthesis and experimentation.…”
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A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…The MHC genes play a key role in the immune responses and are located on the short arm of chromosome 6. …”
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Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma by Zihao Sun, Mengfei Hu, Xiaoning Huang, Minghan Song, Xiujing Chen, Jiaxin Bei, Yiguang Lin, Size Chen

“…In contrast, patients in the low-DCRGS subgroup were resistant to chemotherapy but sensitive to the CTLA-4 immune checkpoint inhibitor and targeted therapy. …”
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Comparative effects of different dietary pectin types on growth performance and intestinal health in pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) by Lulu Zhu, Xiaoxue Meng, Xuehan Wang, Jiongting Fan, Beiping Tan, Junming Deng

“…Daily growth coefficient and feed conversion ratio were calculated to assess growth performance, while intestinal mucosal barrier function as well as intestinal physical, chemical, immune, and biological barrier was evaluated to assess intestinal health. …”
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The Optimum Dietary Phenylalanine Requirement of Hybrid Grouper (Epinephelusfuscoguttatus ♀ × Epinepheluslanceolatus ♂) Juveniles: Effects on Growth Performance, Gut Micromorpholog... by Pinxian Yang, Haijiao Wang, Lei Ma, Haoran Yin, Zhanying Zhu, Cong Liu, Wei Huang, Zhiyu Zhou, Xiaoyi Wu, Sehrish Taj

“…Generally, optimal Phe content in the diet of hybrid grouper was estimated to be 12.7 g/kg of dry matter (27.3 g/kg of dietary protein), and at this level, the feed utilization, gut micromorphology, and immunity of fish were also elevated.…”
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From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment by Basingab FS, Alshahrani OA, Alansari IH, Almarghalani NA, Alshelali NH, Alsaiary AH, Alharbi N, Zaher KA

“…The technical challenges include efficient and targeted delivery to tumor sites without affecting healthy tissue; biological, such as potential toxicity, immune system activation, or resistance mechanisms; economic, involving high production and scaling costs; and regulatory, requiring rigorous testing for safety, efficacy, and long-term effects to meet stringent approval standards. …”
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Multi-omics analysis reveals interactions between host and microbes in Bama miniature pigs during weaning by Wen Ma, Li Yin, Ying Hu, Xu Liu, Zhenghong Guo, Bingyang Zhong, Haofeng Qiu, Jing Li

“…The upregulated genes after weaning were enriched in immune response categories, whereas downregulated genes were enriched in protein degradation. …”
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Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity by Miro Saarela, Essi Parviainen, Ana Lleo, Luca di Tommaso, Hanna Raunio, Krista Kankaanranta, Katri Vuopala, Aino Rönkä, Sini Nurmenniemi, Raija Kallio, Arja Jukkola, Katri S. Selander

“…CD57 + infiltration was similar in normal livers, NASH- and PBC groups, but highly increased in the checkpoint inhibitor-treated patients. Immune cell infiltrates were similar between NASH and normal livers. …”
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Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-𝛼 Antibody in Mice by Masaji Okada, Yoko Kita, Noriko Kanamaru, Satomi Hashimoto, Yasushi Uchiyama, Masahiko Mihara, Yoshikazu Inoue, Yoshiyuki Ohsugi, Tadamitsu Kishimoto, Mitsunori Sakatani

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Mobilization of plant genetic resources from the territory of India by N. P. Loskutova, T. M. Ozerskaya

“…Balabanov took part in a specialized collecting mission launched to study and collect wild forms of rice and to assimilate methods of breeding high-yielding, immune and highquality cultivars. In 1976, an expedition team led by V. …”
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Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV by Diana L. Vares-Lum, Louie Mar A. Gangcuangco, Juwon Park, Eduardo Manzano, Michael Ortega, Dominic C. Chow, Cecilia Shikuma

“…The pathogenesis of CKD in HIV remains poorly understood but is likely from a combination of various factors, such as traditional comorbidities, prolonged antiretroviral therapy, immune dysregulation, and direct HIV effect on the kidneys. …”
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