Correction of cellular and humoral links immunity in piglets under the weaning condition by Nataliia Ohorodnyk, Vitalii Tkachuk, Nataliia Motko, Andriy Boyko, Serhii Pavkovych

“…Accordingly, this study aimed to investigate the effect of a complex liposomal preparation on the cellular and humoral components of the piglet immune system after weaning. A standardised methodology was used to determine the number of different populations and subpopulations of T-lymphocytes in piglet blood samples collected before and at specific intervals after weaning. …”
Get full text

New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine by Minghui Zhang, Minghui Zhang, Zongao Wang, Zongao Wang, Shaojun Liu, Shaojun Liu, Yuxuan Li, Yuxuan Li, Yanting Gong, Yanting Gong, Min Liu, Min Liu

“…In this paper, we review the expression and significance of TRPV1 receptor in various cancer cell types, the role of TRPV1 in the apoptosis-proliferation balance, cancer cell invasion and metastasis, and tumor micro-environment, with emphasis on the mechanisms by which TRPV1 receptor mediates inflammatory response, immune system, and thus regulates cancer. We discussed the latest directions and current challenges of TRPV1 receptor-targeting therapy for cancer, and summarized the odorous traditional herbs that modulate TRPV1 receptors, with a view to developing anti-tumor drugs targeting TRPV1 receptors in the future.…”
Get full text

Distinctive blood and salivary proteomics signatures in Qatari individuals at high risk for cardiovascular disease by Ghada Yousif, Selvasankar Murugesan, Mohamed Nadhir Djekidel, Annalisa Terranegra, Giusy Gentilcore, Jean Charles Grivel, Souhaila Al Khodor

“…Pathway enrichment analysis of the differentially detected proteins revealed that the immune system activation and extracellular matrix remodeling are the most enriched pathways in the CVD-HR group. …”
Get full text

Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…Cancer vaccines are an effective combinatorial partner to sensitize the host immune system to the tumor and boost the efficacy of immune therapies. …”
Get full text

An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells. by Heidi H Cao, Sabrina Molina, Susan Sumner, Blake R Rushing

“…Aflatoxin B1 (AFB1) is a class 1 carcinogen and mycotoxin known to contribute to the development of hepatocellular carcinoma (HCC), growth impairment, altered immune system modulation, and malnutrition. AFB1 is synthesized by Aspergillus flavus and is known to widely contaminate foodstuffs, particularly maize, wheat, and groundnuts. …”
Get full text

The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook by Hager Mohamed, Vandana Miller, Stephen R. Jennings, Brian Wigdahl, Fred C. Krebs

“…They activate the adaptive immune system upon recognition of pathogen-associated molecular patterns (PAMPs) on infected cells. …”
Get full text

Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women by Débora Nonato Miranda de Toledo, Priscilla Vilela dos Santos, Nathalia Sernizon Guimarães, Alessandra de Paula Carli, Patrícia Regina Soares de Souza, Luiza Oliveira Perucci, Caio César de Souza Alves, André Talvani

“…Immunosenescence is a process of immune system remodeling based on the natural aging process. …”
Get full text

Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration by Susanne W. Bruun, Knud Josefsen, Julia T. Tanassi, Aleš Marek, Martin H. F. Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C. Antvorskov, Jesper Larsen, Niels H. Heegaard, Karsten Buschard

“…If present in pancreas, gliadin could interact directly with the immune system and the beta cells to initiate diabetes development. …”
Get full text

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. …”
Get full text

The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition by Yiming Zhou, Haoyu Lu, Shen Zhao, Beibei Yan, Hong Wang, Xiaoli Zhou, Ying Xiao

“…The gut is home to a large number of intestinal microbiota that play an important role in the metabolism and immune system of the host. A growing body of evidence suggests that a high-fat diet is closely associated with many metabolic disorders, including fatty liver and type 2 diabetes. …”
Get full text

Cyanidin-3-O-Glucoside Modulates the In Vitro Inflammatory Crosstalk between Intestinal Epithelial and Endothelial Cells by Daniela Ferrari, Francesco Cimino, Deborah Fratantonio, Maria Sofia Molonia, Romina Bashllari, Rossana Busà, Antonella Saija, Antonio Speciale

“…Intestinal epithelium represents a protective physical barrier and actively contributes to the mucosal immune system. Polarized basolateral intestinal secretion of inflammatory mediators, followed by activation of NF-κB signaling and inflammatory pathways in endothelial cells, efficiently triggers extravasation of neutrophils from the vasculature, therefore contributing to the development and maintenance of intestinal inflammation. …”
Get full text

Protective Effects of Sanyar Prebiotic on Immunity and Tissue Changes of Common Carp (Cyprinus carpio) Exposed to CuSO4 Stress by Ramezan Rajani, Mohammad Farhangi, Hojjatallah Jafaryan, Hossein Adineh, Maryam Alizadeh

“…Prebiotics, as feed additives, can activate the antioxidant and immune systems of fish and significantly improve the survival of aquaculture animals in stressful conditions. …”
Get full text

Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…Immunotherapy has emerged as a promising alternative, harnessing the immune system to target cancer cells. However, the complexity of immune responses and tumor heterogeneity challenges its effectiveness. …”
Get full text

Risk factors and outcomes of vitamin D deficiency in very preterm infants by Hannah Cho, Yoon Lee, Saelin Oh, Ju Sun Heo

“…Background: Vitamin D is essential for bone health and immune system. Vitamin D deficiency (VDD) poses a high-risk to very preterm (VP) infants. …”
Get full text

Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…It emphasizes their beneficial effects on respiratory health by modulating intestinal microbial equilibrium, augmenting immune system functionality, and attenuating inflammatory responses. …”
Get full text

Therapeutic Anticoagulation with Argatroban and Heparins Reduces Granulocyte Migration: Possible Impact on ECLS-Therapy? by Andre Bredthauer, Manuel Kopfmueller, Michael Gruber, Sophie-Marie Pfaehler, Karla Lehle, Walter Petermichl, Timo Seyfried, Diane Bitzinger, Andreas Redel

“…Nevertheless, they can also have a negative effect on the immune system. This study is aimed at investigating the influence of these substances on polymorphonuclear neutrophils (PMNs), whose nonspecific defense mechanisms can promote thrombogenesis. …”
Get full text

Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link? by Dorin Nicolae Gheorghe, Liliana Foia, Vasilica Toma, Amelia Surdu, Elena Herascu, Dora Maria Popescu, Petra Surlin, Cristin Constantin Vere, Ion Rogoveanu

“…The changes caused by the infection in the subjects’ immune system, diet, and lifestyle can facilitate the development of oral conditions such as periodontal disease. …”
Get full text

On the space of SARS-CoV-2 genetic sequence variants by A. Yu. Palyanov, N. V. Palyanova

“…These new data potentially contain information about the mechanisms of the variability and spread of the virus, its interaction with the human immune system, the main parameters characterizing the mechanisms of the development of a pandemic, and much more. …”
Get full text

Protease shaving of Mycobacterium tuberculosis facilitates vaccine antigen discovery and delivery of novel cargoes to the Mtb surface by Bianca A. Lepe, Christine R. Zheng, Owen K. Leddy, Benjamin L. Allsup, Sydney L. Solomon, Bryan D. Bryson

“…Together, these studies reveal potential novel targets for new Mtb vaccines as well as facilitate new approaches to study difficult-to-study cellular compartments during bacterial growth and infection.IMPORTANCEThe surface of a bacterial pathogen is a critical interface between the bacterium and the immune system. A better understanding of this interface would facilitate the discovery of new vaccine targets, new virulence proteins, and enable new technologies that modify the bacterial surface. …”
Get full text

Estimating the Effectiveness of Pfizer and Sinopharm Vaccines and their Relationship to Occupation, Residence, Smoking, and Body Mass Index During Pregnancy Smoking by Shahad Th. Jameel, Asmaa Haseeb Hwaid, Abdulrazak SH. Hasan

“…Vaccination contributes to preventing infection associated with symptoms and reduces the risk of infection by stimulating the immune system to produce antibodies. This study aimed to determine the effectiveness of Pfizer and Sinopharm vaccines and their relationship to occupation, residence, pregnancy, mass index, and smoking. …”
Get full text