Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy: Preliminary Study by Dorota Romaniuk, Malgorzata W. Kimsa, Barbara Strzalka-Mrozik, Magdalena C. Kimsa, Adam Kabiesz, Wanda Romaniuk, Urszula Mazurek

“…Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR. …”
Get full text

Lactoferrin Induces Osteoblast Growth through IGF-1R by Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu

“…Conclusion. Lactoferrin induced IGF-1/IGF-1R in a concentration-dependent manner. …”
Get full text

Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway by Bin Yan, Canjun Zeng, Yuhui Chen, Minjun Huang, Na Yao, Jie Zhang, Bo Yan, Jiajun Tang, Liang Wang, Zhongmin Zhang

“…Interestingly, col-I protein, col-I mRNA, col-III protein, col-III mRNA, and IGF-1 protein, but not IGF-1 mRNA, were inhibited by IGF-1 neutralizing antibody. …”
Get full text

Expression of Concern: Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation. by PLOS One Editors

Get full text

Expression of Concern: Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation

Get full text

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…To evaluate the impact of IGF-1 deficiencies on interneuron development, IGF-1R levels were reduced in the neocortex of neonatal conditional IGF-1R knock out mice by viral injections. …”
Get full text

GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly by Xia Wu, Lu Gao, Xiaopeng Guo, Qiang Wang, Zihao Wang, Wei Lian, Wei Liu, Jian Sun, Bing Xing

“…The thyroid gland volume was significantly increased in patients with higher random GH (p=0.01), higher nadir GH (p=0.008), and higher IGF-1 level (p=0.018). Age (p=0.002) was an independent risk factor for thyroid morphological abnormalities in acromegaly. …”
Get full text

Impact of strict IGF1 control on quality-of-life scores in patients with acromegaly by Chaitanya Gandhi, Marie-Claire Denis, Daniel Holmes, Juan Rivera, Stan van Uum, Shereen Ezzat, Constance Chik

“…ObjectiveExamine, in a real-world setting, whether strict normalization of modestly elevated insulin-like growth factor 1 (IGF1) results in clinical and health-related quality of life benefits in patients with acromegaly using an open-label, non-randomized, 6-month prospective interventional study.MethodsIn patients with acromegaly and modest IGF1 elevation, strict IGF1 control was achieved by addition or dose escalation of pegvisomant. …”
Get full text

PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer by A. Belfiore, M. Genua, R. Malaguarnera

“…In this regard, promising drugs have been developed to target the IGF-I receptor or its ligands. These therapies are limited by the development of insulin resistance and compensatory hyperinsulinemia, which in turn, may stimulate cancer growth. …”
Get full text

Stress-Activated Protein Kinases (SAPKs) in IGF-I Mediated Cell Survival by Darren Krause, Anthony Lyons, Patrick Walsh, Rosemary O’Connor

Get full text

IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels by José Fernando Maya-Vetencourt, Laura Baroncelli, Alessandro Viegi, Ettore Tiraboschi, Eero Castren, Antonino Cattaneo, Lamberto Maffei

“…Moreover, we show that a transitory increase of IGF-1 expression is associated to the plasticity reinstatement induced by environmental enrichment (EE) and that blocking IGF-1 action by means of the IGF-1 receptor antagonist JB1 prevents EE effects on plasticity processes.…”
Get full text

IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Thus, IGF-1R may be a potential therapeutic target for patients with different malignancies. …”
Get full text

Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty by Helena-Jamin Ly, Helena-Jamin Ly, Carina Ankarberg-Lindgren, Hans Fors, Hans Fors, Staffan Nilsson, Jovanna Dahlgren, Jovanna Dahlgren

“…Insulin-like growth factor-1 (IGF-1) is a tool for monitoring GH treatment and dosing. …”
Get full text

IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers by Figen Aydin, Ahmet Kaya, Levent Karapinar, Mert Kumbaraci, Ahmet Imerci, Hasan Karapinar, Cengiz Karakuzu, Mustafa Incesu

“…There was no significant difference in initial IGF-1 levels between the two groups (P=0.399). The mean IGF-1 level increased with HBOT (P<0.05). …”
Get full text

Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs by Ariadne Malamitsi-Puchner, Despina D. Briana, Dimitrios Gourgiotis, Maria Boutsikou, Karl-Philipp Puchner, Stavroula Baka, Antonios Marmarinos, Dimitrios Hassiakos

“…Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. …”
Get full text

The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones by Marcello Maggio, Francesca De Vita, Alberto Fisichella, Fulvio Lauretani, Andrea Ticinesi, Graziano Ceresini, Anne Cappola, Luigi Ferrucci, Gian Paolo Ceda

“…Epidemiological data more consistently support an association between lower testosterone and anemia in adult-older individuals. Low IGF-1 has been especially associated with anemia in the pediatric population and in a wide range of disorders. …”
Get full text

Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…The anti-IAP antibody inhibited IGF-I-stimulated SHPS-1, p52Shc, MAP kinase phosphorylation, and proliferation in endothelial cells. …”
Get full text

Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain by Edoardo Parrella, Valter D. Longo

“…Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. …”
Get full text

Dietary Supplementation of Astragalus Polysaccharides Enhanced Immune Components and Growth Factors EGF and IGF-1 in Sow Colostrum by Lunbo Tan, Ting Wei, Anwen Yuan, Jun He, Jinhui Liu, Daojun Xu, Qing Yang

“…Samples were measured using porcine immunoglobulin (Ig) G, IgM, classical swine fever virus antibody (CSFV Ab), epidermal growth factor (EGF), and insulin-like growth factor- (IGF-) 1 ELISA Quantitation Kits. Dietary supplementation of APS significantly enhanced the presence of IgG, IgM, EGF, and IGF-1 in 0 h-colostrum (P<0.001). …”
Get full text

Study of long-acting vs daily growth hormone: peak levels, AUC, action duration, and IGF-1 by Ashraf Soliman, Fawzia Alyafei, Nada Alaaraj, Noor Hamed, Shayma Mohamed, Ahmed Elawwa, Vincenzo De Sanctis

“…LAGH formulations maintain elevated IGF-1 levels for extended periods, in contrast to the episodic peaks and troughs of natural GH secretion. …”
Get full text