Improving CD3 bispecific antibody therapy in solid tumors using combination strategies by Katy Lloyd, Jim Middelburg, Vitalijs Ovcinnikovs, Nora Pencheva, Kristel Kemper, Thorbald van Hall

“…There are numerous FDA-approved CD3 bsAbs for both hematological and solid tumors. Despite these recent advances, the success of CD3 bsAbs in solid cancer has been hampered by hurdles like limited intratumoral T cell numbers, immunosuppressive tumor microenvironments (TME), and poor memory T-cell induction. …”
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Comparative Effectiveness of Remestemcel-L-rknd versus Ruxolitinib in Pediatric Patients with Steroid-Refractory Acute Graft-Versus-Host Disease using Simulated Treatment Compariso... by Gabriel Tremblay, Dimitrios Tomaras, Eric Strati, Anna Forsythe

“…**Background:** Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a lifesaving treatment for hematologic malignancies, but acute graft-versus-host-disease (aGVHD) is a potentially deadly adverse effect experienced by up to half of allo-HSCT recipients. …”
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Oral health status in children undergoing chemotherapy at Erbil city: A case control study. by Zahraa Emaad Ahmed, Sazan Sherdl Salim

“…Conclusion: Children affected by hematological diseases showed higher rates of plaque but with no significant differences when compared to the controls. …”
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Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? by Andrea Zajacova, MD, Hélène Schoemans, MD, PhD, Mark Greer, MD, MRCP, Hildegard Greinix, MD, Peter Jaksch, MD, Osnat Shtraichman, MD, Rayid Abdulqawi, MD, PhD, Are M. Holm, MD, PhD, Robin Vos, MD, PhD, Saskia Bos, MD, PhD

“…This review addresses common concerns regarding referral and listing of PcGvHD patients for LuTx (such as risk of relapse of hematological malignancy, infectious complications and rejection) and survival outcomes of this specific cohort of patients. …”
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Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment by Rahul Navab, Pragyat Futela, Verkha Kumari, Jayesh Valecha, Ramansh Bandhu Gupta, Rohit Jain

“…Multiple Myeloma (MM) is a hematologic malignancy characterized by clonal plasma cell development, leading to serious complications. …”
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Antiphospholipid Syndrome as a Cause of Recurrent Portal Vein Thrombosis in a Man with a Medical History of other Thrombosis by R. G. Sayfutdinov, R. R. Saifutdinov, R. R. Akhunova, T. V. Saifutdinova, G. R. Absalyamova, T. V. Dvoryankina, G. R. Akhunova

“…APS is a syndrome that includes venous and/or arterial thrombosis, various forms of obstetric pathology, thrombocytopenia, as well as a variety of neurological, skin, cardiovascular and hematological disorders. The article presents a clinical case of a male patient with several episodes of vascular thrombosis, two of which (thrombophlebitis of the veins of the lower extremities and stroke) developed at the age of 39 years, and recurrent thrombosis of the portal vein since 2018. …”
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Correction of Thrombocytopenia with Thrombopoietin Receptor Agonists in Patients with Liver Cirrhosis Before Elective Surgery or Invasive Procedures by T. A. Deeva, M. V. Maevskaya, V. T. Ivashkin

“…Thrombocytopenia is a common hematological complication of liver cirrhosis, affecting up to 75–86 % of patients with decompensated cirrhosis. …”
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Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease by Zachary Kostamo, Manuel A. Ortega, Chavonna Xu, Patricia R. Feliciano, Elizabeth Budak, Daisy Lam, Valerie Winton, Rebecca Jenkins, Archita Venugopal, Margaret Zhang, John Jamieson, Brent Coisman, Kennedy Goldsborough, Britney Hernandez, Celeste K. Kanne, Erica N. Evans, Jordan Zgodny, Yankai Zhang, Jawa Darazim, Ashwin Patel, Michael A. Pendergast, John Manis, Adam J. Hartigan, Giuseppe Ciaramella, Seung-Joo Lee, S. Haihua Chu, Vivien A. Sheehan

“…Our results highlight the importance of functionally assessing the mature red cell environment when evaluating novel gene editing strategies for hematologic disorders.…”
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Prevalence and community awareness of bovine Trypanosomiasis in Wolaita zone Kindo Koysha woreda, southern Ethiopia by Saifemichael Ushecho, Amene Fekadu

“…Generally, both focus group discussion and hematological findings revealed bovine trypanosomiasis is the major constraint for livestock production in the area. …”
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Serological estimation of values for urea, uric acid, and creatinine as a prognostic marker in oral submucous fibrosis patients: An institutional clinic-biochemical study by Vishal Mehrotra, Kriti Garg, Rahul Srivastava, Shazia Aslam, Jyoti Kiran, Vinayak Rai

“…Background: The changes observed in the hematological/serological values and histopathological findings in oral submucous fibrosis (OSMF) patients may help in providing insight into the pathogenesis of this premalignant condition. …”
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Impact of nutritional screening on mortality and intensive care unit length of stay by Blanca Cecilia Díaz Chavarro, Blanca Cecilia Díaz Chavarro, Manuel Romero-Saldaña, Manuel Romero-Saldaña, Jorge Karim Assis Reveiz, Guillermo Molina-Recio, Guillermo Molina-Recio

“…The other cohort of 630 patients was those exposed to screening with the Malnutrition Universal Screening Tool (MUST) scale. Hematological, clinical, and nutritional variables were considered and their relationship with adverse events, length of hospital stay, and discharge status.ResultsThere were significant differences between the two cohorts (p < 0.001), with increased mortality and length of hospital stay in patients who received standard nutritional screening without MUST. …”
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Acute Stroke Management and Outcome: An Experience from One Private Tertiary Care Center in Eastern India by Debabrata Chakraborty, Devarati Biswas, Sakshi Puri, Abdul Malik, Shagufta Eqbal, Insha Aleena, Ritwika Ghosh, Sadanand Dey, Priyanjita Sen, Sucharita Paul

“…In relation to an acute stroke, we noted patient demographics, clinical, radiological, and hematological details, treatment, and outcome (in hospital and after 3 months). …”
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Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…It also showed significantly improved persistence and comparable tumor control in a microphysiological human in vitro model and a xenograft model of human glioblastoma, but also demonstrated increased off-target recognition of IL-13Rα1.Conclusion Taken together, this work demonstrates the utility of extending CARPOOL to diseases beyond hematological malignancies and represents the largest exploration of signaling combinations in human primary cells to date.…”
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Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

“…We examine the circumstances that led to the approval of rituximab and trastuzumab, the first successful antibodies for the treatment of hematologic and solid cancers. We detail the generation of the ADC and BsAb formats that dramatically augmented antibody-mediated precision cytotoxicity. …”
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Biochemical Status of Beta-Thalassemia Major Patients in Erbil City by Omar Surchi, Sarkawt Ali

“… Background and objectives: β -thalassemia major patient is one of the hereditary hemolytic diseases, which can cause many hematological and biochemical changes in the affected patient. …”
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Risk Factors and Predictive Model for Disseminated Intravascular Coagulation in Patients with Multiple Myeloma by Rong Bao MM, Mengtong Fan MM, Min Hu MM, Ling Li BD,   Hasichaolu BD

“…Objectives Multiple myeloma (MM) is a hematologic malignancy comprising approximately 10% of all blood cancers. …”
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Clinical round: 27 year old patient with initially diagnosed Crohn's disease and severe protein and energy deficiency by V. S. Scherbakha, O. Z. Okhlobystina, A. V. Korolev, O. S. Shifrin, A. V. Stepanov, A. S. Tertychny, A. V. Okhlobystin, V. T. Ivashkin

“…Later on patient underwent examination to exclude hematological disorder. In 1.5 years before admission to Vasilenko clinic of Sechenov University patient lost 30 kg of body weight. …”
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Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice by Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette

“…Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types of hematological malignancies, but have shown limited efficacy in patients with glioblastoma (GBM) or other solid tumors. …”
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The influence of sex on sleep characteristics in the adult and older adult population: findings from the EPISONO sleep study by Mayra dos Santos Silva, Priscila Farias Tempaku, Priscila Farias Tempaku, Monica Levy Andersen, Monica Levy Andersen, Sergio Tufik, Sergio Tufik, Dalva Poyares, Dalva Poyares

“…They also underwent full-night polysomnography (PSG) and peripheral blood collection for biochemical and hematological measurements. In both editions (2007 and 2015), physical and anthropometric assessments were also assessed. …”
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Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

“…Background Chimeric antigen receptor natural killer (CAR-NK) therapy holds great promise for treating hematologic tumors, but its efficacy in solid tumors is limited owing to the lack of suitable targets and poor infiltration of engineered NK cells. …”
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