A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens by Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, Irene Li, Asmita Bhattacharya, Yuanyuan Li, Winston Trope, Joseph B. Shrager, Calvin Kuo, Michael G. Ozawa, Amato J. Giaccia, Lu Tian, Sylvia K. Plevritis

Get full text

The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers by Siyer Roohani, Jolina Handtke, Kamal Hummedah, Markus Albertsmeier, Dimosthenis Andreou, Leonidas Apostolidis, Marinela Augustin, Sebastian Bauer, Moritz Billner, Florian Bösch, Christoph K. W. Deinzer, Niklas Deventer, Anna Duprée, Franziska Eckert, Lars Engel, Katja Fechner, Hagen Fritzsche, Verena Gaidzik, Saeed Ghani, Robert Grützmann, Wiebke K. Guder, Rainer Hamacher, Judith S. Hecker, Anne Hendricks, Axel Hillmann, Philipp Houben, Georg Hübner, Philipp Ivanyi, Christina Jentsch, Maren Jordan, Peter Kappl, Moritz Kaths, Torsten Kessler, Johanna Kirchberg, Carolin Knebel, Robert Krempien, Burkhard Lehner, Ulrich Lenze, Lars H. Lindner, Alisa Martina Lörsch, Nadia Maguire, Sophie Müller, Pompiliu Piso, Vlatko Potkrajcic, Peter Reichardt, Stephan Richter, Simone Schewe, Lars M. Schiffmann, Felicitas Scholten, Jana Käthe Striefler, Matthias Schwarzbach, Katharina Seidensaal, Sabine Semrau, Joanna Szkandera, Christoph J. Szuszies, Beate Timmermann, Armin Tuscherer, Armin Wiegering, Moritz T. Winkelmann, David Kaul, Jens Jakob

Get full text

β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

Get full text

Identification and validation of hub gene TNFAIP6 of fibroblast-like synoviocytes in rheumatoid arthritis by LEI Lei, LYU Yuxin, ZHANG Jing

Get full text

Simulations of pH and thermal effects on SARS-CoV-2 spike glycoprotein by Ziyuan Niu, Georgios Kementzidis, Miriam Rafailovich, Marcia Simon, Evangelos Papadopoulos, Bertal H. Aktas, Yuefan Deng

Get full text

Primary liver lymphoma: review of the literature and clinical case presentation by A. K. Smolyaninova, A. V. Gubkin, Ye. Ye. Zvonkov, Yu. A. Kucheryavy

Get full text

Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

Get full text

A Nomogram for Predicting Overall Survival in Primary Central Nervous System Lymphoma: A Retrospective Study by Ling Y, Miao X, Zhou X, Ma J, Lin Z, Li Q, Zhang M, Ma Y, Chen B

“…Yunan Ling,* Xiaqi Miao,* Xiang Zhou,* Jingjing Ma, Zhiguang Lin, Qing Li, Mengxue Zhang, Yan Ma, Bobin Chen Department of Hematology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bobin Chen, Department of Hematology, Huashan Hospital, Fudan University, 12 Urumuqi Road (Middle), Shanghai, 200040, People’s Republic of China, Email bbchen@fudan.edu.cnPurpose: Current prognostic scoring systems for newly diagnosed primary central nervous system lymphoma (PCNSL), such as IELSG prognostic score and MSKCC prognostic score, are widely used but have limitations in clinical practice. …”
Get full text

Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer by Jessica Filoni, Arianna Ferrari, Tatiana Jofra, Anna Rita Putignano, Lorenzo Da Dalt, Susanna Cesarano, Carla Di Dedda, Fabrizia Bonacina, Federica Marchesi, Danilo Norata, Chiara Bonini, Lorenzo Piemonti, Paolo Monti

Get full text

The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review by Faris Shweikeh, Yuhao Zeng, Abdur Rahman Jabir, Erica Whittenberger, Saurav P. Kadatane, Yuting Huang, Mohamad Mouchli, Dani Ran Castillo

Get full text

Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients by Chong Zhang, Wenjin Peng, Meng Ning, Weiru Liang, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Yingwu Liu

Get full text

Editorial: Obesity and cancer: the possible molecular links by Biswarup Basu, Debanjan Chakroborty, Debanjan Chakroborty, Debanjan Chakroborty, Chandrani Sarkar, Chandrani Sarkar, Chandrani Sarkar

Get full text

Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention by Fuli Fan, Shubei Liu, Bin Wang, Xiaojian Song, Wei Wang

Get full text

Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations by Verena Vogi, David Haschka, Lukas Forer, Simon Schwendinger, Verena Petzer, Stefan Coassin, Ivan Tancevski, Thomas Sonnweber, Judith Löffler-Ragg, Elisabeth Puchhammer-Stöckl, Marianne Graninger, Dominik Wolf, Florian Kronenberg, Johannes Zschocke, Emina Jukic, Günter Weiss

Get full text

Correction of Thrombocytopenia before Elective Surgery / Invasive Procedures in Patients with Liver Cirrhosis (Experts’ Agreement) by M. V. Maevskaya, M. Yu. Nadinskaia, E. N. Bessonova, N. I. Geyvandova, M. S. Zharkova, E. A. Kitsenko, N. V. Korochanskaya, I. A. Kurkina, A. L. Melikyan, V. G. Morozov, Yu. V. Khoronko, T. A. Deeva, K. A. Gulyaeva, V. T. Ivashkin

“…The Russian Scientific Liver Society selected a panel of experts in the field of therapeutic and surgical hepatology, hematology, transfusion medicine to make reasoned statements and recommendations on the issue of treatment of thrombocytopenia before elective surgery / invasive procedures in patients with liver cirrhosis.Results. …”
Get full text

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer by Anne Mills, Leisha A Emens, Mary L Disis, Kunle Odunsi, John B Liao, Tyler Curiel, Margaret Gatti-Mays, Amir Jazaeri, Emese Zsiros, Marcus O Butler, Jyoti Bajpai, Katherine C Kurnit, Haider Mahdi, Laura Doherty, Claire F Friedman, Melissa A Geller, Sarah F Adams, Shelley A Dodt, Veena S John

Get full text

miR-182 promoter hypermethylation predicts the better outcome of AML patients treated with AZA + VEN in a real-world setting by Yilan Xu, Danyang Li, Na Wang, Bei Ge, Chen Meng, Min Zhao, Zihan Lin, Min Li, Yigang Yuan, Yue Cai, Liuzhi Shi, Shenmeng Gao, Haige Ye

“…To determine whether miR-182 promoter methylation is a predictive marker of clinical outcomes in AZA + VEN-treated AML patients in a real-world setting, we analyzed and compared the complete remission (CR)/CR with incomplete hematologic recovery (CRi) rate, overall survival (OS), and leukemia free-survival (LFS) across different methylation groups: miR-182 promoter hypomethylation (median value < 20.21%) and hypermethylation (> 20.21%) in a retrospective study. …”
Get full text

The Diagnostic Pitfall of Lymphadenopathy: Ultrasonic Imaging Findings in a Case of Cat Scratch Lymphadenitis by Li Tiantian, Zhu Miao, Shen Dejuan, Qian Xiaoqin

Get full text

A Nomogram Based on Circulating Inflammatory Factors for Predicting Prognosis of Newly Diagnosed Multiple Myeloma Patients by Wang M, Yue X, Ding Y, Cai Z, Xiao H, Huang H, He J

“…Mowang Wang,1– 4,&ast; Xiaoyan Yue,5,&ast; Yingying Ding,5,&ast; Zhen Cai,1,4 Haowen Xiao,5 He Huang,1– 4 Jingsong He1,4 1Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang Province, People’s Republic of China; 3Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; 4Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang Province, People’s Republic of China; 5Department of Hematology and Cell Therapy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: He Huang; Jingsong He, Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang Province, 310006, People’s Republic of China, Email huanghe@zju.edu.cn; hejingsong@zju.edu.cnPurpose: The growth and survival of multiple myeloma (MM) cells depend heavily on bone marrow microenvironment, where inflammation emerges as a significant feature and is commonly associated with unfavorable prognosis in MM. …”
Get full text

Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

Get full text