Anti-HSV-1 agents: an update by Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian

Subjects: “…HSV-1…”
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HSV-1 miR-H6 Inhibits HSV-1 Replication and IL-6 Expression in Human Corneal Epithelial Cells In Vitro by Fang Duan, Jingyu Liao, Qiang Huang, Yuhong Nie, Kaili Wu

“…HSV-1 infection in the cornea could lead to blindness. …”
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Advanced progress in the genetic modification of the oncolytic HSV-1 virus by Mi Zhou, Mi Zhou, Mi Zhou, Zhenyu Shen, Zhenyu Shen, Zhenyu Shen

“…Certain genetic alterations have shown efficacy in improving clinical outcomes for HSV-1-based therapies. These modifications include silencing specific genes and inserting exogenous genes into the HSV-1 genome. …”
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Antiviral activity of Ferula assa-feotida on HSV-1, 2 in vitro by Javad Charostad, Tahere Navidfar, Masoumeh Kiani, Paul Schinitzler, Akram Astani

“…No HSV-1 or HSV-2 activity was detected in cells treated prior to and following viral infection. …”
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The Role of Cyclooxygenase in Multiplication and Reactivation of HSV-1 in Vestibular Ganglion Neurons by Yuehong Liu, Shufeng Li, Zhengmin Wang

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to suppress reactivation of HSV-1 in trigeminal ganglions. However, whether this drug can affect reactivation of HSV-1 in vestibular ganglions is unclear. …”
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HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia by Mark R. Wallace

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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Therefore, In order to reduce the GCV dose required, we aim to compare the therapeutic efficacy of HSV1-sr39TK, an HSV1-TK mutant with increased GCV prodrug catalytic activity, with wildtype TK in C6 glioma cells. …”
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Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection by Chandran Ramakrishna, Mari S. Golub, Abby Chiang, Teresa Hong, Markus Kalkum, Edouard M. Cantin

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Prolonged Intractable Hiccups Associated with HSV (I&II) Esophagitis and H. pylori Gastritis by Christina Hopkins, Asha Bansari, Michael Ladna, Bahram Dideban

“…EGD revealed circumferential ulceration of middistal esophagus and biopsies confirmed HSV (I&II) esophagitis and H. pylori gastritis. He was prescribed triple therapy for H. pylori and acyclovir for HSV esophagitis. …”
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A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1 by Juan Xiang, Chaoyang Fan, Hongchang Dong, Yilei Ma, Pei Xu

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An updated review of HSV-1 infection-associated diseases and treatment, vaccine development, and vector therapy application by Dan Su, Liping Han, Chengyu Shi, Yaoxin Li, Shaoju Qian, Zhiwei Feng, Lili Yu

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Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors by Lin Wei, Yang Hu, Licheng Bai, Chenxu Xiao, Zhang Liu, Yun You, Keke Wang, Yunyuan Huang, Junfei Zhu, Jun Weng, Wenling Zhou, Han Li, Honghe Zhao, Zhiyong Wu, Meng Mei, Zigong Wei

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Evaluation of anti-viral photodynamic therapy effects of different concentrations of 5-ALA using light irradiation on HSV-1 by Farhad Farzaneh, Masoud Parsania, Mitra Sadeghpour Natanzi, Negar Parsania, Mohammad Amin Salehi, Sepehr Fekrazad, Hamed Bagheri, Reza Fekrazad

“…Six experimental groups were used: [1] Control (no 5-ALA or light), HSV-1 with 0.05 g/ml 5-ALA and 630 nm light, [2] HSV-1 with 0.05 g/ml 5-ALA (no light), [3] HSV-1 with 0.1 g/ml 5-ALA and light, [4] HSV-1 with 0.1 g/ml 5-ALA (no light), and [5] HSV-1 with light (no 5-ALA). …”
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Physiological oxygen concentration during sympathetic primary neuron culture improves neuronal health and reduces HSV-1 reactivation by Sara A. Dochnal, Patryk A. Krakowiak, Abigail L. Whitford, Anna R. Cliffe

“…Furthermore, culture in these lower oxygen conditions diminishes the progression to full HSV-1 reactivation despite minimal impacts on latency establishment and earlier stages of HSV-1 reactivation. …”
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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. …”
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Different Strategies for Reducing Intestinal Background Radioactivity Associated with Imaging HSV1- Expression Using Established Radionucleoside Probes by Alessandro Ruggiero, Peter Brader, Inna Serganova, Pat Zanzonico, Shangde Cai, Neil S. Lipman, Hedvig Hricak, Ronald G. Blasberg

“…One limitation of HSV1- tk reporter positron emission tomography (PET) with nucleoside analogues is the high background radioactivity in the intestine. …”
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HIV-1 Replication in HIV-Infected Individuals Is Significantly Reduced When Peripheral Blood Mononuclear Cells Are Superinfected with HSV-1 by Taneth Yamsuwan, Chintana Chirathaworn, Pokrath Hansasuta, Parvapan Bhattarakosol

“…This study investigated HSV-1 replication in PBMCs from 25 HIV-infected individuals and 15 healthy donors and the effects of HSV-1 superinfection on HIV-1 production. …”
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A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs’ Susceptibility by Souichi Yamada, Shizuko Harada, Hikaru Fujii, Hitomi Kinoshita, Phu Hoang Anh Nguyen, Miho Shibamura, Tomoki Yoshikawa, Madoka Kawahara, Hideki Ebihara, Masayuki Saijo, Shuetsu Fukushi

Subjects: “…herpes simplex virus type 1 (HSV-1)…”
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Interest and Expectations for a Herpes Vaccine Among People Diagnosed with Genital HSV 1-2 Infection: Results from an Italian Survey by Lovel Lisac, Angelo Roberto Raccagni, Riccardo Lolatto, Flavia Passini, Chiara Maci, Elena Bruzzesi, Nicolò Moschetta, Antonella Castagna, Silvia Nozza

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Biological Evaluation of 3-Aryl and/or 4-(<i>N</i>-Aryl)aminocoumarins Against Human Pathogens: Antileishmanial and Antiviral Activities by Vitor Won-Held Rabelo, Leonardo Simões de Abreu Carneiro, Luan Letieri Belem Martins, Fernando Almeida-Souza, Luciene Soares Silva, Leonardo dos Santos Corrêa Amorim, Maria Leonisa Sanchez-Nuñez, Kátia da Silva Calabrese, Paula Alvarez Abreu, Camilla Djenne Buarque, Izabel Christina Nunes de Palmer Paixão

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