Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. by June Yao, Tu Cam Le, Claudine H Kos, Joel M Henderson, Phillip G Allen, Bradley M Denker, Martin R Pollak

“…Focal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults such as diabetes, HIV infection, and hypertension. Point mutations in the alpha-actinin-4 gene ACTN4 cause an autosomal dominant form of human FSGS. …”
Get full text

Influence of Domestic Violence on Pupils Academic Performance in Rubanda District. by Busingye, Scholar

“…The study found that 100% of respondents agreed on several causes of domestic violence, which included unfaithfulness, poverty (12 respondents, 20%), early marriages (5 respondents, 8%), diseases such as HIV/AIDS (9 respondents, 15%), gender inequality (10 respondents, 16%), and alcoholism (10 respondents, 16%). …”
Get full text

The mucosal barrier and anti-viral immune responses can eliminate portions of the viral population during transmission and early viral growth. by Ryan V Moriarty, Athena E Golfinos, Dane D Gellerup, Hannah Schweigert, Jaffna Mathiaparanam, Alexis J Balgeman, Andrea M Weiler, Thomas C Friedrich, Brandon F Keele, Miles P Davenport, Vanessa Venturi, Shelby L O'Connor

“…Little is known about how specific individual viral lineages replicating systemically during acute Human Immunodeficiency Virus or Simian Immunodeficiency Virus (HIV/SIV) infection persist into chronic infection. …”
Get full text

Identification of Mutations that Encode Drug Resistance in the Polymerase Gene of the Human Immunodeficiency Virus by Zhengxian Gu, Hengsheng Fang, Horacio Salomon, Qing Gao, Mark A Wainberg

“…In vitro selection in MT-4 cells was used to generate human immunodeficiency virus-type 1 (HIV 1) variants that are resistant to 2',3'-dideoxycytidine (ddC), 2',3'-didcoxyinosine (ddI) and the (-) enantiomer of 2' ,3'-dideoxy-3'-thiacytidine (3TC). …”
Get full text

Clinic Attendance for Medication Refills and Medication Adherence amongst an Antiretroviral Treatment Cohort in Uganda: A Prospective Study by Setor Kunutsor, John Walley, Elly Katabira, Simon Muchuro, Hudson Balidawa, Elizabeth Namagala, Eric Ikoona

“…Regular clinic attendance for antiretroviral (ARV) drug refills is important for successful clinical outcomes in HIV management. Methods. Clinic attendance for ARV drug refills and medication adherence using a clinic-based pill count in 392 adult patients receiving antiretroviral therapy (ART) in a district hospital in Uganda were prospectively monitored over a 28-week period. …”
Get full text

New Tools in HCV Diagnosis, in Light of the Enhanced Awareness and the New Drugs for Treatment: SMARTube and Stimmunology by Svetlana Gorodin, Serhat Unal, Youchun Wang, Mikhail I. Mikhaylov, Ludmila Bigbulatova, Tamar Jehuda-Cohen

“…To address these challenges an innovative device—SMARTube HIV & HCV—was used. Blood samples were tested for anti-HCV antibodies before and after incubation in the SMARTube, which promotes the in vitro stimulation of in vivo HCV primed lymphocytes, thus enhancing levels of anti-HCV antibodies. …”
Get full text

PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing by Patricia E. Almeida, Alan Brito Carneiro, Adriana R. Silva, Patricia T. Bozza

“…Tuberculosis continues to be a global health threat, with drug resistance and HIV coinfection presenting challenges for its control. …”
Get full text

Applying ‘timeliness’ to the screening and prevention of TB in household contacts of pulmonary TB patients by A. D. Harries, D. Nair, P. Thekkur, R. Ananthakrishnan, R. Thiagesan, J. M. Chakaya, I. Mbithi, B. Jamil, R. Fatima, M. Khogali, R. Zachariah, S. Dar Berger, S. Satyanarayana, A. M. V. Kumar, A. F. Bochner, A. McClelland

Get full text

Leclercia adecarboxylata Cholecystitis with Septic Shock in Immunocompetent Patient by Nooraldin Merza, John Lung, Ahmed Taha, Ahmed Qasim, Jill Frost, Tarek Naguib

“…Vitals showed a temperature of 37°C, pulse of 110 beats/min, blood pressure of 75/50 mmHg, and oxygen saturation of 91% on room air. An HIV panel and hepatitis panel were negative. Liver and gallbladder ultrasound was performed, revealing multiple nonmobile stones with shadowing noted within the gallbladder sac, a thickened gallbladder wall, and a moderate amount of pericholecystic fluid. …”
Get full text

Modulation of first-passage time for bursty gene expression via random signals by Qiuying Li, Lifang Huang, Jianshe Yu

“…This can provide theoretical guidance for studies of some cellular key events such as latency of HIV and lysis time of bacteriophage $λ.$ In conclusion, our results reveal impacts of external signal on FPT and aid understanding the regulation mechanism of gene expression.…”
Get full text

Community support for injured patients: A scoping review and narrative synthesis. by Rashi Jhunjhunwala, Anusha Jayaram, Carol Mita, Justine Davies, Kathryn Chu

“…<h4>Background</h4>Community-based peer support (CBPS) groups have been effective in facilitating access to and retention in the healthcare system for patients with HIV/AIDS, cancer, diabetes, and other communicable and non-communicable diseases. …”
Get full text

Coccidioidomycosis Masquerading as Eosinophilic Ascites by Kourosh Alavi, Pradeep R. Atla, Tahmina Haq, Muhammad Y. Sheikh

“…He had eosinophilia of 11.1% with negative testing for stool studies, HIV, and tuberculosis infection. Ascitic fluid exam was remarkable for low serum-ascites albumin gradient (SAAG), PMN count >250/mm3, and eosinophils of 62%. …”
Get full text

Is tattooing associated with increased seroprevalence of transfusion-transmitted infections among blood donors: A single-center study from Southeastern India by Charumathy Arjunan, Abhishekh Basavarajegowda

“…The serological prevalence of the two groups was compared for HIV, hepatitis B virus, hepatitis C virus, Syphilis, and Malaria. …”
Get full text

Women’s Perspectives on Influencers to the Utilisation of Skilled Delivery Care: An Explorative Qualitative Study in North West Ethiopia by Biruhtesfa Bekele Shiferaw, Lebitsi Maud Modiba

“…The factors that influenced or motivated women to give birth in health facility in their previous, current, and future pregnancies include access to ambulance transport service, prevention of mother to child HIV transmission service, referral service, women friendly service, and emergency obstetric services, good interpersonal care from health workers, and fear and experience of obstetric danger signs and complications. …”
Get full text

Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination by Farhad Ghanizadeh Gerayeli, Farnaz Hosseini, Zohreh Bagheri, Amir Savardashtaki, Zahra Shabaninejad, Ali Mohammad Amani, Sohrab Najafipour

“…Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. …”
Get full text

Stress and Traditional Support: The Role of Orphans’ and Vulnerable Children’s Primary Caregivers in Rural Ethiopia by Aweke Tadesse, Kenan Li, Jesse Helton

“…Background/Objectives: Orphans’ and Vulnerable Children’s (OVC) primary caregivers (PCGs) in Ethiopia live with multiple social and emotional problems stemming from extreme poverty, war, environmental disasters, and the HIV pandemic. Family and community supports are strained, leaving OVC’s PCGs dependent on inconsistent humanitarian aid. …”
Get full text

SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject by R. Wumba, M. Mandina, Y. Nlandu, J. R. Makulo, A. Tshimpi, P. Mbala, A. Mbangama, P. Kabututu, J. M. Kayembe

“…The model was then compared to data from the HIV literature. Conclusion. Reported data could contribute to a better understanding of molecular mechanisms of cellular infection by SARS-CoV-2 as well as to a more easy explanation of the action of pharmacological agents used for the treatment, while elucidating intimate mechanisms of the immunity of infected subject.…”
Get full text

Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) by J. M. Kagira, N. Maina, J. Njenga, S. M. Karanja, S. M. Karori, J. M. Ngotho

“…The observed co-infections included malaria (100%), helminthosis (64.5%), typhoid (22.5%), urinary tract infections (16.1%), HIV (12.9%), and tuberculosis (3.2%). The species of helminthes observed included Ancylostoma duodenale (38.7%), Ascaris lumbricoides (45.7%), Strongyloides stercoralis (9.7%), and Taenia spp. (3.2%). …”
Get full text

Usual prevention in unusual settings: A scoping review of place-based health interventions in public-facing businesses. by Jack Tsai, Nicholas A McCann

“…These 42 studies were categorized based on health conditions of focus, including cardiovascular health (12 studies); HIV (6 studies); diabetes (5 studies); cancers (13 studies); and all other conditions (14 studies). …”
Get full text

TB preventive therapy: uptake and time to initiation during implementation of ‘7-1-7’ by A.D. Harries, D. Nair, P. Thekkur, R. Ananthakrishnan, R. Thiagesan, J.M. Chakaya, I. Mbithi, B. Jamil, R. Fatima, M. Khogali, R. Zachariah, S.D. Berger, S. Satyanarayana, A.M.V. Kumar, A.F. Bochner, A. McClelland

Get full text