Torsades de Pointes due to Excessive Marijuana Use in a Susceptible Patient by Vivek D. Shah, Adeba Mohammad, Shuktika Nandkeolyar, Liset Stoletniy, Tahmeed Contractor

“…While she demonstrated normal baseline QTc measurements years earlier, she was found to have a genetic predisposition to QTc prolongation (genetic mutation, family history of prolonged QTc), suggesting that specific patient populations are at higher risk of these adverse events. …”
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Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus by Jolanta Dorota Torzecka, Joanna Narbutt, Anna Sysa-jedrzejowska, Maciej Borowiec, Anetta Ptasinska, Grzegorz Woszczek, Marek L. Kowalski

“…The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. …”
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Febrile Seizures and Febrile Seizure Syndromes: An Updated Overview of Old and Current Knowledge by Abdulhafeez M. Khair, Dalal Elmagrabi

“…Their etiology and pathophysiological pathways are being understood better over time; however, there is still more to learn. Genetic predisposition is thought to be a major contributor. …”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…Several genetic factors are involved in OA, including inherited genes, genetic susceptibility, and genetic predisposition. As the pathogenesis of OA is unknown, there are almost no effective treatments available to prevent the onset or progression of the disease. …”
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Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions by Diletta Bonciani, Alice Verdelli, Veronica Bonciolini, Antonietta D'Errico, Emiliano Antiga, Paolo Fabbri, Marzia Caproni

“…There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. …”
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Hereditary colorectal cancer: genetics and screening diagnostics by O. I. Kit, D. I. Vodolazhsky, Yu. A. Gevorkyan, N. V. Soldatkina, F. N. Grechkin, M. A. Kozhushko, I. Yu. Yefimova

“…In 30% of cases disease development is associated to genetic predisposition, however only 5% of all CRC cases are linked to established hereditary syndromes, such as Lynch syndrome (hereditary non-polyposis colorectal cancer), family adenomatous polyposis, MUTYH-associated polyposis, juvenile polyposis, hereditary mixed polyposis syndrome, Peutz-Jeghers syndrome and serrated polyposis syndrome. …”
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Polymorphism of genes and drug-induced liver injury by P. Ye. Tkachenko, M. V. Mayevskaya, V. T. Ivashkin

“…The most cases are related to idiosyncrasy phenomenon which is based on genetic predisposition for production of reactive metabolites at xenobiotic transformation reactions in the liver. …”
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Inflammatory Bowel Disease in Indo-Canadians with and without Antineutrophil Cytoplasmic Autoantibodies by Hugh James Freeman

“…This study supports the view that these diseases arise in individuals with a genetic predisposition following exposure to some, as yet unknown, environmental factor.…”
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The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population by Svitlana Yermolenko, Yaroslav Chumachenko, Viktor Orlovskyi, Irina Moiseyenko, Oleksandr Orlovskyi

“…Arterial hypertension (AH) belongs to the diseases with genetic predisposition that determines the necessity of research on the genetic component’s influence on this disease development. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…Although the exact etiology of TAK remains unclear, a genetic predisposition to the disease has been established. …”
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Blood Vessel Segmentation and Classification of Diabetic Retinopathy with Machine Learning-Based Ensemble Model by Cihan Akyel, Bünyamin Ciylan

“…The incidence of diabetes has increased in recent times due to factors such as obesity and genetic predisposition. Diabetes wears out the eye vessels over time. …”
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Finding Genetic Risk Factors of Gestational Diabetes by Soo Heon Kwak, Hak C. Jang, Kyong Soo Park

“…Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy that is suspected to have a strong genetic predisposition. It is associated with poor perinatal outcome, and both GDM women and their offspring are at increased risk of future development of type 2 diabetes mellitus (T2DM). …”
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Age-related features of alpha rhythm dynamics: a brief review by I.S. Polikanova, I.N. Mikheev, S.V. Leonov, O.V. Martynova

“…Parameters of the alpha rhythm, such as individual stability, genetic predisposition, and age-related characteristics, make it a promising marker for both normative development and brain aging in determining cognitive and biological age.…”
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Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration by Nicolas De Schryver, Xavier Wittebole, Peter Van den Bergh, Vincent Haufroid, Eric Goffin, Philippe Hantson

“…In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. …”
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A modern approach to the treatment of plaque psoriasis by Drvar Daniela Ledić, Vlahinić Tomislav, Maleš Željan, Turčić Petra, Čeović Romana

“…The etiopathogenesis of the disease is multifactorial, the key factors being genetic predisposition combined with immunological disorders, environmental factors and skin barrier damage. …”
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Plotting of Ethylene Glycol Blood Concentrations Using Linear Regression before and during Hemodialysis in a Case of Intoxication and Pharmacokinetic Review by Youngho Kim

“…Pharmacokinetic review revealed minimal elimination of EG by alcohol dehydrogenase (ADH) which could be related to genetic predisposition for ADH activity and home medications as well as presence of propylene glycol. …”
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Susceptibility to Aneuploidy in Young Mothers of Down Syndrome Children by Lucia Migliore, Francesca Migheli, Fabio Coppedè

“…That study indicated that women who have a DS child at a young age might have a genetic predisposition to chromosome malsegregation in both somatic and germ line cells. …”
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Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B by I. G. Bakulin

“…Rates of progression of persistent HBV infection to liver cirrhosis stage depend on several factors – spectrum of viral markers, immune status of the patient, his/her age, gender, genetic predisposition, etc. Lamivudine has capacity for prolonged and persistent block of HBV replication. …”
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Asthma in Sickle Cell Disease by Manisha Newaskar, Karen A. Hardy, Claudia R. Morris

“…In patients with a genetic predisposition of atopic asthma, these changes are probably more severe and result in increased susceptibility to sickle cell complications. …”
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FROM ONCOLOGIST TO SURGEON - GENETICS IN COLORECTAL METASTASIS FOR SURGEONS by Marília Polo Mingueti e SILVA, Jorge SABBAGA, Henry Luiz NAJMAN, Carlos David Carvalho NASCIMENTO, Ricardo Lemos COTTA-PEREIRA, João Eduardo Leal NICOLUZZI, Maria Ignez BRAGHIROLI

“…The percentage of patients with a true hereditary genetic predisposition is less than 10%, and these are related to the presence or absence of colonic polyps as an important manifestation of the disease. …”
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