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Expression of palmitoyl transferases in brain structures of mice genetically predisposed to depressive-like behavior
Published 2018-08-01“…However, the study demonstrates that the genetic predisposition to depression-like behavior in ASC mice is not associated with changes in ZDHHC5, ZDHHC9, or ZDHHC21 palmitoyl transferase expression.…”
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Systemic Lupus Erythematosus (SLE): A review on the prevalence, clinical manifestation, and disease assessment
Published 2020-09-01“…The aetiology of SLE is not fully understood, but both genetic predisposition and ecological triggers are thought to be involved in the disease manifestation. …”
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Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions
Published 2024-01-01“…The report delves into the patient’s complex background, including psychosocial stressors, genetic predisposition to depression, and a history of personality traits that may have influenced her response to ketamine. …”
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Non-Scarring Alopecia in Females: A Comprehensive Review
Published 2024-08-01“…Various aetiologic factors are implicated in non-scarring alopecia, including genetic predisposition, loss of immune privilege, oxidative damage, and hormonal fluctuations. …”
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Primary Biliary Cirrhosis in A Patient with Turner Syndrome
Published 2005-01-01“…The present case may support the importance of X chromosome genes in the development of genetic predisposition to PBC, and emphasizes the necessity for a systematic study of the prevalence of PBC in patients with Turner syndrome.…”
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Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia
Published 2019-01-01“…The alterations of the CD4/CD8 lymphocyte ratio, relative content of TH17 cells, and intermediate monocytes in FDR are features of genetic predisposition to T2DM and may play a role in pathogenesis of T2DM. …”
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Familial Prevalence of Inflammatory Bowel Disease in Northern Alberta
Published 1990-01-01“…These results support the hypothesis that a genetic predisposition in families combined with possible environmental and lifestyle influences determine the relative risk of developing Crohn's disease and ulcerative colitis.…”
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Understanding cancer predisposition in Singapore: what’s next
Published 2023-01-01“…Knowledge of an underlying genetic predisposition to cancer allows the use of personalised prognostic, preventive and therapeutic strategies for the patient and carries clinical implications for family members. …”
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Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases
Published 2012-01-01“…Microbial dysbiosis in IBD with lack of beneficial bacteria, together with genetic predisposition, is the most relevant conditions in the pathogenesis of the pediatric IBD.…”
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Aortic Disease in the Young: Genetic Aneurysm Syndromes, Connective Tissue Disorders, and Familial Aortic Aneurysms and Dissections
Published 2013-01-01“…In the absence of familial history and other clinical findings, the proportion of thoracic and abdominal aortic aneurysms and dissections resulting from a genetic predisposition is still unknown. In this study, we propose the review of the current genetic knowledge in the aortic disease, observing, in the results that the causative genes and molecular pathways involved in the pathophysiology of aortic aneurysm disease remain undiscovered and continue to be an area of intensive research.…”
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Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients
Published 2017-01-01“…Emergence of autoimmune thyroid diseases depends upon genetic predisposition and environmental triggers. Mechanism of action for isotretinoin is not known but the drug may play a role in triggering autoimmunity in genetically susceptible individuals.…”
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End-stage ADPKD with a low-frequency PKD1 mosaic variant accelerated by chemoradiotherapy
Published 2024-03-01“…This case highlights how environmental factors may contribute to the genetic predisposition to ADPKD.…”
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Type 2 Diabetes Mellitus in a 15 Years Old Adolescent: Case Report and Literature Review
Published 2024-04-01“…The main risk factors for suffering from it in adolescents are: obesity, genetic predisposition and family history. The case of a 15-year-old female patient who attended health services with a previous diagnosis of prediabetes and overweight is presented. …”
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Dandy-Walker Syndrome. Case Report and Literature Review
Published 2022-11-01“…It is mainly based on an abnormal development of the cerebrospinal fluid communication pathways. Genetic predisposition associated with malformations and chromosomal alterations has been suggested. …”
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Review of NVP and HG and Early Pharmacotherapeutic Intervention
Published 2012-01-01“…The most common etiologies for NVP include the hormonal changes associated with pregnancy, the physiologic changes in the gastrointestinal tract, and a genetic predisposition. Up to 10% of women will require pharmacotherapy to treat the symptoms of NVP despite conservative measures. …”
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Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy
Published 2018-08-01“…The etiology and pathogenesis of ICP are related to disorders of bile acid metabolism caused by hormonal factors (elevation of estrogen and progesterone levels) and genetic predisposition. The leading clinical signs of ICP include pruritus and jaundice that develop most commonly in the third trimester of pregnancy, and characteristic changes of laboratory scores: increase in bile acid level (over 10 mcmol/l) and moderate elevation of transaminase activity. …”
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Signaling Pathway Puts the Break on Fat Cell Formation
Published 2001-01-01“…These environmental factors may be complicated in some individuals by an unfavorable genetic predisposition. Pharmaceutical companies lead active research programs to identify drugs that target weight control centers in the body and which may help individuals control their weight; however, no satisfactory magic bullet to fight obesity has yet come through the pipeline [7,8].…”
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Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences
Published 2012-01-01“…By helping parents and young children change certain behaviors and exposures during critical time periods, we may be able to alter or modify one’s genetic predisposition. However, further research is needed to determine which efforts are effective at decreasing the incidence of obesity and to develop new methods of prevention. …”
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Natural Killer Cell and Large Granular Lymphocyte Deficiency in the Gut of Children with Inflammatory Bowel Disease
Published 1990-01-01“…The lack of natural killer cells and LGL in the gut epithelium in children with IBD may be indicative of a possible genetic predisposition. The authors also present a new therapeutic strategy consisting of low dose interferon-alpha-2a that is efficacious in ameliorating ulcerative col iris and Crohn's disease and concomitantly increasing the number of natural killer cells and LGL in the gut.…”
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Construction of an Integrated Positive Youth Development Conceptual Framework for the Prevention of the Use of Psychotropic Drugs among Adolescents
Published 2011-01-01“…Theories of drug use and abuse, including neurological, pharmacological, genetic predisposition, psychological, and sociological theories, were reviewed. …”
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