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A double dissociation between semantic and spatial cognition in visual to default network pathways
Published 2025-01-01Get full text
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo
Published 2024-12-01“…In this study, we rationally designed a bpAb, KJ015, that shares a common light chain with two Fab arms and exhibits functionally balanced high affinity for two HER2 non-overlapping epitopes. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody
Published 2024-12-01“…Herein, we dissect the molecular mechanism of 23ME–00610 blockade of hCD200R1 by solving the crystal structure of 23ME–00610 Fab in complex with hCD200R1 and performing mutational studies, which show 23ME–00610 blocks the interaction between hCD200 and hCD200R1 through steric hindrance. …”
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Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae
Published 2025-02-01“…Abstract Background The structure of chloroplast genomes (cpDNAs) in Fabaceae (Fab.) has undergone significant evolutionary modifications. …”
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1117
Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma
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1118
A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome
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1119
Ethnobotanical survey on anti-tuberculosis plants in Mbujimayi, Democratic Republic of the Congo
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1120
Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs
Published 2024-12-01Get full text
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