Flexibility in PAM recognition expands DNA targeting in xCas9 by Kazi A Hossain, Lukasz Nierzwicki, Modesto Orozco, Jacek Czub, Giulia Palermo

“…xCas9 is an evolved variant of the CRISPR-Cas9 genome editing system, engineered to improve specificity and reduce undesired off-target effects. …”
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Ambient wing cistern: History, anatomy, imaging and approaches: An overview by Mohamed R. Emara, Alkawthar M. Abdulsada, Abdulaziz S. Alayyaf, Hussein A. Baban, Hala A. Al-Hchaimi, Mustafa Ismail, Samer S. Hoz

“…Results: 836 results were obtained, after exclusion of unrelated engineering articles and veterinary papers, only 60 papers remained. …”
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Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis by Hui Liu, Xiaojuan Bi, Ning Yang, Xue Zhang, Bingbing Fang, Nuerbaiti Kusuman, Wenmei Ma, Jing Li, Jin Chu, Li Sun, Liang Li, Guodong Lü, Renyong Lin

“…Abstract Accumulating evidence has shown that adipose-derived stem cells (ADSCs) have the potential to differentiate into hepatic lineages, which are ideal engraftments for tissue-engineered repair. In this study, we investigated the potential of transplanted induced hepatocyte-like cells (iHEPs) in treating hepatic alveolar echinococcosis and describe an efficient three-step protocol for the generation of iHEPs in vitro from ADSCs. …”
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Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…Simultaneously, OVT leverages genetically engineered viruses to selectively destroy cancer cells and stimulate robust antitumor immune responses. …”
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PROSPECTS AND CHALLENGES OF RESCUING THE SHRINKING LAKE CHAD THROUGH THE UNITED NATIONS’ GREEN CLIMATE FUND by DAIYABU HASSAN MUHAMMAD

“…The most viable plan is the idea of an inter-basin water transfer (IBWT), developed by the Italian Engineering Company Bonfica which involves diverting about 4% of the waters of the tributaries of River Bongi in the Democratic Republic of Congo (DRC) that discharge into the Atlantic Ocean through a series of canals and dams to River Chari (that feeds the Lake) in the Central African Republic (CAR). …”
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Spatial Variations in PAHs and Nitro-PAHs Bound to Total Suspended Solids in Urban Locations in Taiwan by Hsin-Chieh Kung, Bo-Wun Huang, Justus Kavita Mutuku, Guo-Ping Chang-Chien

“…Diagnostic ratios indicate the dominance of combustion processes, especially from diesel engines, in the emission of PAHs and nitro-PAHs compared to petrogenic emissions. …”
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Hydraulic fracture propagation characteristics of directional perforation fracturing in horizontal wells for deep coalbed methane by Shuxin HUANG, Song LI, Bo CHEN

“…However, the mechanisms of hydraulic fracture initiation and propagation under the influence of geological and engineering factors remain unclear. To explore directional perforation fracturing characteristics in deep coal seams, a three-dimensional discrete lattice simulation algorithm was used to establish a numerical model. …”
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Protocol for a systematic review of economic evaluations considering costs and health outcomes of weather and climate-related extreme events in humans by Collins Iwuji, Saeideh Babashahi, Kingsley Orievulu, Ekeminiabasi Eyita-Okon, Dominic Kniveton

“…A comprehensive search will be conducted using several search engines, for example, PubMed, Scopus and Institute for Scientific Information Web of Science. …”
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ErbB- and MUC1-targeted CAR-T cell immunotherapy of oral squamous cell carcinoma by Saffron E. Summers, Saffron E. Summers, Vehid Salih, Andrew D. Foey

“…In this review, the process of CAR-T cell engineering and different generations of these cells will be summarised, highlighting their potential use in treating HNSCC through targeting ErbB and MUC1; TAAs highly expressed by this solid tumour. …”
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Benefit Evaluation of Different Allocation Modes of Soil and Water Conservation Measures in Ta-pieh Mountains Area by ZHOU Jie, TIAN Pei, WU Yijin, JIA Tinghui, SHEN Chenzhu

“…[Results] (1) There was no obvious benefit of soil and water conservation in normal farming, but the benefit of soil and water conservation was improved under terraced field + tillage mode, and the comprehensive benefit of stone ridge terraced field + peanut-rape was the best, and the reduction rate of soil erosion reached 55%; (2) The allocation mode of biological measures combined with engineering measures has good water and soil conservation benefits, but there are differences in the benefits of runoff and sediment reduction. …”
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Assessing Driving Risk Level: Harnessing Deep Learning Hybrid Model With Intercity Bus Naturalistic Driving Data by Wei-Hsun Lee, Che-Yu Chang

“…Through comprehensive feature engineering and examinations of three temporal neural models, this research identifies the best parameter configurations. …”
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A literature review of climate-smart landscapes as a tool in soil- water management in Sub-Saharan Africa by Turyasingura, Benson, Tumwesigye, Wycliffe, Atuhaire, Abraham, Tumushabe, Jennifer Turyatemba, Akatwijuka, , Rogers

“…Using "landscape governance" AND "climate smart landscape," 31 papers (31) were obtained from the Web of Science (WOS) and twenty-nine (27) from the Scopus databases using search engines from (1992-2022). On equitable climate-smart landscapes, it was found that multi-stakeholder participation in landscape management is an iterative and changing process that can assist in addressing and resolving disputes as well as facilitating fair negotiation procedures for underrepresented and minority groups. …”
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Internet Usage and Academic Performance of Students At Uganda Martyrs University Kabale Campus. by Niwashaba, Brendah

“…From the study findings, upgrading the system, organizing internet training, installation of generating set, institutional subscription to some sites, employing computer engineers, increasing work station, continuous system maintenance, and installation of a library dedicated server were some of the possible solutions to the challenges encountered by students in the use of internet facilities at Uganda Martyrs University, Kabale campus. …”
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Improving the Properties of Non G30 Soil for Use as Subbase Material with Tea Production Waste-Lime Blend. by Baluku, Bennet

“…This research examined the potential of enhancing the engineering properties of non-G30 soil from Kabale Municipality for use as subbase material by stabilizing it with a mixture of lime and tea production waste. …”
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Assessing the Effect of Saturation Variations on the Factor of Safety of Slopes in Elgon Sub-Region. by Muboki, Peterson

“…In conclusion, this research contributes valuable insights into geotechnical engineering practices in the Elgon sub-region. By understanding how saturation affects slope stability, we can develop informed management strategies for similar geological settings. …”
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Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer by Congcong Chen, Yang Li, Yayun Gu, Qiqi Zhai, Songwei Guo, Jun Xiang, Yuan Xie, Mingxing An, Chenmeijie Li, Na Qin, Yanan Shi, Liu Yang, Jun Zhou, Xianfeng Xu, Ziye Xu, Kai Wang, Meng Zhu, Yue Jiang, Yuanlin He, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Juncheng Dai, Guangfu Jin, Zhibin Hu, Cheng Wang, Hongxia Ma, Hongbing Shen

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One-pot green synthesis of BSA-capped O-CQDs as an effective fluorescent sensing platform for sensitive and selective detection of promethazine drug by S. Viji, A. Dinesh, K. Radhakrishnan, L. Srimathi Priya, C. Sivasankari, Madhappan Santhamoorthy, Manikandan Ayyar, V. Mohanavel, Mohamed Hashem, Hassan Fouad, G. Ramachandran, S. Santhoshkumar

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Formulating a Blue Ocean Strategy in the Banking Services Industry: Enhancing Customer Satisfaction through Improved Demand Fulfillment and Presenting an Optimal Pattern by Manuchehr Ghanbari, Ali Sabzali Yameqani, Yousef Rabbani, Kobra Sabzali Yamaqani

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Which impacts matter for pavement management decisions? Quantifying social sustainability based on a capability approach by Jessica Boakye, Egemen Okte

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Protocol for automated tracking and quantification of adult zebrafish anxiety behavior using ZebraTrack by Atanu Pramanik, Shubham Nema, Yogesh Bhargava, Anamika Bhargava

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