Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosisResearch in context by Matthew Lynch, Sophie Manoy, Peter D. Sly, Claire E. Wainwright, Ernst Wolvetang, John E. Feenstra, Jason Dowling, Robert S. Ware, Maharshi S. Patel, Diana Hermith-Ramirez, Adam Vogel, Kahn Preece, Tania Zappala, Shuan Dai, Ann Webber, Abrey Yeo, Goutham Subramanian, Geetha Rao, Cindy S. Ma, Sara Jose, Magtouf Gatei, Bowen Xin, Nicoletta Sandona, Peter Lewindon, Katherine G. Sinclair, Sam Nayler, Martin F. Lavin, David J. Coman

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The effect of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and ratsResearch in context by Rune Ehrenreich Kuhre, Borja Ballarín-González, Christian Lehn Brand, Tine Glendorf, Kim Grimstrup Madsen, Karina Rahr Hjøllund, Wouter Frederik Johan Hogendorf, David Højland Ipsen, Sofia Lundh, Thomas Kruse, Signe Beck Petersen, Anna Secher, Andreas Vegge, Kirsten Raun

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Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context by Stephen Joza, Aline Delva, Christina Tremblay, Andrew Vo, Marie Filiatrault, Max Tweedale, Jean-François Gagnon, Ronald B. Postuma, Alain Dagher, Johannes Klein, Michele Hu, Petr Dusek, Stanislav Marecek, Zsoka Varga, John-Paul Taylor, John T. O'Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Stéphane Lehéricy, Marie Vidailhet, Jean-Christophe Corvol, ICEBERG Study Group, Richard Camicioli, Howard Chertkow, Simon Lewis, Elie Matar, Kaylena A. Ehgoetz Martens, Lachlan Churchill, Michael Sommerauer, Sinah Röttgen, Per Borghammer, Karoline Knudsen, Allan K. Hansen, Dario Arnaldi, Beatrice Orso, Pietro Mattioli, Luca Roccatagliata, Oury Monchi, Shady Rahayel, Isabelle Arnulf, Samir Bekadar, Eve Benchetrit, Alexis Brice, Vanessa Brochard, Alizé Chalançon, Benoit Colsch, Florence Cormier-Dequaire, Jean-Christophe Corvol, Virginie Czernecki, Bertrand Degos, Cécile Delorme, Pauline Dodet, Carole Dongmo-Kenfack, Marie-Odile Habert, Farid Ichou, Jonas Ihle, Cécile Galléa, Rahul Gaurav, Marie-Alexandrine Glachant, Manon Gomes, David Grabli, Elodie Hainque, Laetitia Jeancolas, Christelle Laganot, Stéphane Lehéricy, Suzanne Lesage, Smaranda Leu-Semenescu, Richard Levy, Valentine Maheo, Graziella Mangone, Louise Laure Mariani, Aurelie Méneret, Poornima Menon, Fanny Mochel, Vincent Perlbarg, Dijana Petrovska, Fanny Pineau, Nadya Pyatigorskaya, Sophie Rivaud-Pechoux, Emmanuel Roze, Sara Sambin, Julie Socha, Arthur Tenenhaus, Romain Valabregue, Marie Vidailhet, Lydia Yahia-Cherif

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The relationship of baseline high-sensitivity C-reactive protein with incident cardiovascular events and all-cause mortality over 20 yearsResearch in context by Adam Hartley, Somayeh Rostamian, Amit Kaura, Paris Chrysostomou, Paul Welsh, Cono Ariti, Naveed Sattar, Peter Sever, Ramzi Khamis

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A probiotic approach identifies a Treg-centred immunoregulation via modulation of gut microbiota metabolites in people with multiple sclerosis and healthy individualsResearch in co... by Constantin Träger, Maria Kaiser, David Freudenstein, Simon Heckscher, Katja Dettmer, Peter J. Oefner, Gerhard Liebisch, Andreas Hiergeist, André Gessner, De-Hyung Lee, Klemens Angstwurm, Ralf A. Linker, Stefanie Haase

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Mechanotransduction as a therapeutic target for brain tumours by Lauren Gomes, Carlos Pardo-Pastor, Jody Rosenblatt, Antonios N. Pouliopoulos

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Multimodal data integration for biologically-relevant artificial intelligence to guide adjuvant chemotherapy in stage II colorectal cancerResearch in context by Chenyi Xie, Ziyu Ning, Ting Guo, Lisha Yao, Xiaobo Chen, Wanghong Huang, Suyun Li, Jiahui Chen, Ke Zhao, Xiuwu Bian, Zhenhui Li, Yanqi Huang, Changhong Liang, Qingling Zhang, Zaiyi Liu

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Artificial intelligence-driven genotype–epigenotype–phenotype approaches to resolve challenges in syndrome diagnosticsResearch in context by Christopher C.Y. Mak, Hannah Klinkhammer, Sanaa Choufani, Nikola Reko, Angela K. Christman, Elise Pisan, Martin M.C. Chui, Mianne Lee, Fiona Leduc, Jennifer C. Dempsey, Pedro A. Sanchez-Lara, Hannah M. Bombei, John A. Bernat, Laurence Faivre, Frederic Tran Mau-Them, Irene Valenzuela Palafoll, Natalie Canham, Ajoy Sarkar, Yuri A. Zarate, Bert Callewaert, Ewelina Bukowska-Olech, Aleksander Jamsheer, Andreas Zankl, Marjolaine Willems, Laura Duncan, Bertrand Isidor, Benjamin Cogne, Odile Boute, Clémence Vanlerberghe, Alice Goldenberg, Elliot Stolerman, Karen J. Low, Vianney Gilard, Jeanne Amiel, Angela E. Lin, Christopher T. Gordon, Dan Doherty, Peter M. Krawitz, Rosanna Weksberg, Tzung-Chien Hsieh, Brian H.Y. Chung

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Hypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studiesResearch in context by Peng Xu, Santiago Estrada, Rika Etteldorf, Dan Liu, Mohammad Shahid, Weiyi Zeng, Deborah Früh, Martin Reuter, Monique M.B. Breteler, N. Ahmad Aziz

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Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood culturesResearch in context by Vincenzo Di Pilato, Chiara Bonaiuto, Fabio Morecchiato, Alberto Antonelli, Tommaso Giani, Gian Maria Rossolini

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COPD risk due to extreme temperature exposure: combining epidemiological evidence with pathophysiological mechanisms by Jiayu Xu, Guogang Xu, Zehua Liu, Ruoyu Hou, John S. Ji, Cunrui Huang

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Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses’ Health Study IIResearch in context by Naoko Sasamoto, Long H. Ngo, Allison F. Vitonis, Simon T. Dillon, Maryam Aziz, Amy L. Shafrir, Stacey A. Missmer, Towia A. Libermann, Kathryn L. Terry

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The vascular-immune-neural network: a new pathophysiological paradigm and the dawn of cytoprotection in stroke by Yiliang Fang, Zhiyi Zhu, John H. Zhang, Fu-Dong Shi, Qingwu Yang

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Evolution of SARS-CoV-2 antibody repertoire after successive mRNA vaccinations under immunosuppressive treatmentResearch in context by Jim B.D. Keijser, Eileen W. Stalman, Luuk Wieske, Maurice Steenhuis, Koos P.J. van Dam, Laura Y.L. Kummer, Zoé L.E. van Kempen, Joep Killestein, Adriaan G. Volkers, Sander W. Tas, Laura Boekel, Gerrit J. Wolbink, Laura Fernandez Blanco, Niels J.M. Verstegen, Sofie Keijzer, Gerard van Mierlo, Olvi Cristianawati, Arend J. Boogaard, Karlijn van der Straten, Jacqueline van Rijswijk, Marit J. van Gils, Anja ten Brinke, S. Marieke van Ham, Taco W. Kuijpers, Filip Eftimov, Theo Rispens, Anneke J. Van der Kooi, Joop Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Geert R.A.M. D'Haens, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma, Marc L. Hilhorst, Yosta Vegting, Frederike J. Bemelman, Alexandre E. Voskuyl, Bo Broens, Agner R. Parra Sanchez, Cécile A.C.M. Van Els, Jelle De Wit, Abraham Rutgers, Karina De Leeuw, Barbara Horváth, Jan J.G.M. Verschuuren, Annabel M. Ruiter, Lotte Van Ouwerkerk, Diane Van der Woude, Renée C.F. Van Allaart, Y.K. Onno Teng, Pieter Van Paassen, Matthias H. Busch, Papay B.P. Jallah, Esther Brusse, Pieter A. Van Doorn, Adája E. Baars, Dirk Jan Hijnen, Corine R.G. Schreurs, W. Ludo Van der Pol, H. Stephan Goedee, Koos A.H. Zwinderman, Rivka De Jongh, Carolien E. Van de Sandt, Lisan H. Kuijper, Mariël C. Duurland, Ruth R. Hagen, Jet Van den Dijssel, Christine Kreher, Amélie V. Bos, Virginia Palomares Cabeza, Veronique A.L. Konijn, George Elias, Elham S. Mirfazeli

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From intensive care monitors to cloud environments: a structured data pipeline for advanced clinical decision supportResearch in context by Sijm H. Noteboom, Eline Kho, Maria Galanty, Clara I. Sánchez, Frans C.P. ten Bookum, Denise P. Veelo, Alexander P.J. Vlaar, Björn J.P. van der Ster

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Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureusResearch in context by Suvendu Ojha, Simran Sinsinwar, Puja Chatterjee, Sarmistha Biswal, Pinkilata Pradhan, Tushar Kant Beuria

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Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic reviewResearch in context by Malak Elbatarny, Yu Tong Lu, Mostin Hu, John Coles, Seema Mital, Amanda Ross-White, Osami Honjo, David J. Barron, Anthony O. Gramolini

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The role of neuroinflammation in cerebral amyloid angiopathy by Hilde van den Brink, Sabine Voigt, Mariel Kozberg, Ellis S. van Etten

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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosisResearch in context by Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong, Ruize Yu, Rong Jiang, Haotian Dai, Jingyuan Zhang, Xiaohua Gu, Yongle Xu, Chunwei Li, Shan Shan, Feng Xu, Yue Hong, Tao Ren

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Investigating the effect of polygenic background on epilepsy phenotype in ‘monogenic’ familiesResearch in context by Karen L. Oliver, Ingrid E. Scheffer, Colin A. Ellis, Bronwyn E. Grinton, Samuel F. Berkovic, Melanie Bahlo, Zaid Afawi, Dina Amrom, Eva Andermann, Jocelyn F. Bautista, Susannah T. Bellows, Judith Bluvstein, Gregory D. Cascino, Seo-Kyung Chung, Patrick Cossette, Sarah W. Curtis, Norman Delanty, Orrin Devinsky, Dennis Dlugos, Michael P. Epstein, Catharine Freyer, Micheline Gravel, Rebekah V. Harris, Erin L. Heinzen, Olivia J. Henry, Heidi E. Kirsch, Robert C. Knowlton, Eric H. Kossoff, Rebecca Loeb, Daniel H. Lowenstein, Anthony G. Marson, Heather C. Mefford, Paul V. Motika, Terence J. O'Brien, Ruth Ottman, Juliann M. Paolicchi, Slave Petrovski, William O. Pickrell, Mark I. Rees, Lynette G. Sadleir, Jerry J. Shih, Rani K. Singh, Michael C. Smith, Philip E.M. Smith, Rhys H. Thomas, Judith Weisenberg, Peter Widdess-Walsh, Melodie R. Winawer

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