Spectrum and Clinical Characteristics of Renal Diseases in Ghanaian Adults: A 13-Year Retrospective Study by Perditer Okyere, Isaac Okyere, Richard Kobina Dadzie Ephraim, Joseph Attakorah, Charlotte Osafo, Bernard Arhin, Sarah Bachelle, Albert Abaka-Yawson

“…We conclude that hypertension, chronic glomerulonephritis, diabetic nephropathy, and sepsis are the most common causes of renal diseases. …”
Get full text

Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Background Kidney fibrosis is the common final pathway of virtually all advanced forms of chronic kidney disease (CKD) including diabetic nephropathy (DN), IgA nephropathy (IgAN) and membranous nephropathy (MN), with complex mechanism. …”
Get full text

Community-based model for management and follow-up by non-physician healthcare workers to improve awareness, treatment, and control of hypertension: The COTRACO study protocolDetai... by A.J. Lora Mantilla, L.A. Parra Gomez, P.A. Camacho-López, J. Otero-Wandurraga, B. Novella, A. González-Medina, O. Valdez-Tiburcio, F. Lanas, M.C. Rocha-Lezama, J. Alonzo-Arias, C. Rivilla-Piñango, C. Cáceres-Ramírez, S.J. Villabona-Flórez, Y.M. Giraldo-Castrillón, P. López-Jaramillo

“…Expected outcomes: The primary outcome at 12 months of follow-up is the percentage of patients achieving controlled hypertension (defined as systolic BP < 140 mmHg and diastolic BP < 90 mmHg, or < 130 mmHg, and diastolic BP < 80 mmHg for diabetic patients), ensuring it is not inferior to that achieved in the control countries. …”
Get full text

Heart Rate in Hypertension: Review and Expert Opinion by Jamshed Dalal, Arup Dasbiswas, Immaneni Sathyamurthy, Srinivasa Rao Maddury, Prafulla Kerkar, Sandeep Bansal, Joy Thomas, Sankar Chandra Mandal, Soura Mookerjee, Sivakadaksham Natarajan, Viveka Kumar, Nishith Chandra, Aziz Khan, R. Vijayakumar, J. P. S. Sawhney

Get full text

Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…., San Francisco, CA, USA; 6Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA; 7Ophthalmology Division, Creighton University School of Medicine, Phoenix, Arizona, USACorrespondence: Jordan M Graff, Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA, Tel +1 480 843 1868, Email JGraff@BDPEC.comPurpose: Faricimab, the first bispecific antibody designed for intraocular use, is approved for the treatment of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). …”
Get full text

Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation by Hui Liao, Yuanping Li, Xilan Zhang, Xiaoyun Zhao, Dan Zheng, Dayue Shen, Rongshan Li

“…Our previous study on diabetic nephropathy rats indicated that thalidomide (Tha) has renoprotective properties. …”
Get full text

Facteurs associés aux spondyloarthrites axiales difficiles à traiter : résultats d’une étude rétrospective mono centrique sur 134 patients. by G Ndaie, P Lebughe, M Nzita, M Muamba, K Lobukulu, J Kanku, F Kemiche, M Chammakhi, S Rezki, C Mulumba, M Jenny, KJJ Malemba

“…Il n’y avait pas de différence quant à l’âge moyen des patients, aux comorbidités comme l’HTA et le diabète sucré et l’ancienneté de l’AxSpA. Conclusion : D2T AxSpA a concerné 35% des patients de notre étude, elle a été associée à l’inflammation biologique, à la présence d’enthésites et à la fibromyalgie/dépression. …”
Get full text

Thrombotic vs. Bleeding Events of Interruption of Dual Antiplatelet Therapy within 12 Months among Patients with Stent-Driven High Ischemic Risk Definition following PCI by Hao-Yu Wang, Bo Xu, Chen-Xi Song, Chang-Dong Guan, Li-Hua Xie, Yan-Yan Zhao, Zhong-Xing Cai, Sheng Yuan, Ke-Fei Dou

“…These findings were consistent across various stent-driven high-ischemic risk subsets with respect to the primary ischemic endpoints, with a greater magnitude of harm among patients with diffuse multivessel diabetic coronary artery disease. Conclusions. In patients undergoing high-risk PCI, interruption of DAPT in the first 12 months occurred infrequently and was associated with a significantly higher adjusted risk of major adverse cardiovascular events and net adverse clinical events. 2017 ESC stent-driven high ischemic risk criteria may help clinicians to discriminate patient selection in the use of long-term DAPT when the ischemic risk certainly overcomes the bleeding one.…”
Get full text

Comparative safety of the sodium glucose co-transporter 2 (SGLT2) inhibitors: a systematic review and meta-analysis by Kris Aubrey-Bassler, John-Michael Gamble, Jennifer R Donnan, Catherine A Grandy, Eugene Chibrikov, Carlo A Marra, Karissa Johnston, Michelle Swab, Jenna Hache, Daniel Curnew, Hai Nguyen

“…Random effects models were used to estimate pooled relative risks (RRs).Intervention SGLT2 inhibitors, compared with placebo or active comparators.Primary outcomes Acute kidney injury (AKI), diabetic ketoacidosis (DKA), urinary tract infections (UTI), bone fractures and lower limb amputations.Results We screened 2418 citations of which 109 were included. …”
Get full text

miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma by Xiaoyuan Lu, Li Jing, Sicong Liu, Haihong Wang, Buze Chen

“…MiR-149-3p may be involved in the occurrence and development of UCEC via pathways including PI3K-Akt signaling pathway, Ras signaling pathway, AGE-RAGE signaling pathway in diabetic complications, focal adhesion, and MAPK signaling pathway. miR-149-3p may inhibit the function of CD8 T cells, cytotoxic cells, eosinophils, iDC, mast cells, neutrophils, NK CD56bright cells, NK CD56dim cells, pDC, T cells, T helper cells, TFH, Th17 cells, and Treg. miR-149-3p was significantly upregulated in UCEC cell lines compared with endometriotic stromal cells. …”
Get full text

Overcoming beta-lactam resistance in Pseudomonas aeruginosa by targeting metallo-beta-lactamase VIM-1: a one-microsecond molecular dynamics simulation study by Mohammed Salleh M. Ardawi, Samar A. Badreddine, Muhammad Yasir, Muhammad Yasir, Aiah M. Khateb, Aiah M. Khateb, Safaa A. Turkistani, Ahmed Afandi, Samah O. Noor, Adhari Alselmi, Adhari Alselmi, Vivek Dhar Dwivedi, Vivek Dhar Dwivedi, Esam I. Azhar, Esam I. Azhar

Get full text

In Vitro Activities of Ceftobiprole and Doripenem Tested against Frequently Encountered Aerobic and Facultative Gram-Positive and Gram-Negative Bacterial Pathogens Isolated from Pa... by James A Karlowsky, Mel DeCorby, Daryl J Hoban, George G Zhanel

“…BACKGROUND: In 2008, ceftobiprole was approved by Health Canada for the treatment of patients with complicated skin and skin structure infections including diabetic foot infections; approval of ceftobiprole by the United States Food and Drug Administration is pending. …”
Get full text

Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. …”
Get full text

Exploring the multifaceted roles of Sonneratia apetala and Nipa fruticans in coastal habitat restoration and bioactive properties discovery by Sabina Yasmine, Rezwana Zaman Proma, Md. Ripaj Uddin, Mohammad Saydur Rahman, Md. Hamedul Islam, Muhammad Abdullah Al Mansur, AHM Shofiul Islam Molla Jamal, Abu Yousuf, Md. Hasnain Mustak, Sarker Kamruzzaman, M. Mahboob Ali Siddiqi

“…Results: S. apetala fruits exhibit substantial antioxidant, antimicrobial, analgesic, antidiarrheal, and anti-diabetic properties. Additionally, the bark and leaves offer considerable therapeutic benefits. …”
Get full text

Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured using Early Treatment Diabetic Retinopathy Study (ETDRS) charts and spectral-domain optical coherence tomography (OCT). …”
Get full text

Comprehensive analysis of Pan-Immune Inflammation and all-cause mortality in rheumatoid arthritis: a database-driven approach, 1999-2018 by Muradil· Mardan, Huoliang Zheng, Qingyin Xu, Shaokuan Song, Zeyu Lu, Hui Deng, Hao Cai, Qizhu Chen, Bingyi Yang, Kudelaiti· Abuduwufuer, Pengbo Chen, Bo Li, Shengdan Jiang, Leisheng Jiang, Xin-feng Zheng

“…Subgroup analyses confirmed consistent findings, with a notable interaction observed in diabetic patients (P for interaction = 0.002).ConclusionsPIV is a significant and independent predictor of all-cause mortality in RA patients, characterized by a nonlinear association and a distinct threshold effect. …”
Get full text

Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

Get full text

Effect of Sucrose Spray on some Phytochemical Characteristics of Stevia (Stevia rebaudiana Bertoni) under Field Conditions by Vahid Akbarpour, Hossein Aruei, Kambiz Mashayekhi, Majid Azizi Arani, Mohammad Ali Bahmanyar

“…One of the features of this sweetener is that it is very useful for diabetics due to its lack of absorption in the digestive system. …”
Get full text

Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“…Methods Thirty-nine (34% female) non-diabetic adults (mean [standard deviation] age 68 [5] years) and body mass index 24.0 [2.6] kg/m2) participated in this double-blind, randomised controlled trial. …”
Get full text