-
101
Candidate Genes Associated with Delayed Neuropsychomotor Development and Seizures in a Patient with Ring Chromosome 20
Published 2020-01-01“…Gene ontology included microtubule-based movement, nucleosome assembly, DNA repair, and cholinergic synaptic transmission. Defects in these bioprocesses are associated with the development of neurological diseases, intellectual disability, neuropathies, and seizures. …”
Get full text
Article -
102
Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair
Published 2025-01-01“…Here, we report that inhibitors of glycogen synthase kinase 3 beta (GSK3β) and the homologous recombination DNA repair (HRR) pathway are synthetic lethal with FHIT loss in lung cancer. …”
Get full text
Article -
103
FBP1 Is an Interacting Partner of Menin
Published 2014-01-01“…Menin interacts with proteins that regulate transcription, DNA repair and processing, and maintenance of cytoskeletal structure. …”
Get full text
Article -
104
Silver single atoms and nanoparticles on floatable monolithic photocatalysts for synergistic solar water disinfection
Published 2025-01-01“…The photothermal effect of the plasmonic Ag nanoparticles reduces the bacterial resistance to ROS and impairs DNA repair capabilities. Under sunlight irradiation, the synergistic effect of Ag single atoms and nanoparticles enables 4.0 cm2 AgSA+NP/ZIF to achieve over 6.0 log inactivation (99.9999%) for the stress-resistant Escherichia coli (E. coli) in oligotrophic surface water within 30 min. …”
Get full text
Article -
105
Role of sirtuins in epigenetic regulation and aging control
Published 2024-04-01“…This multifactorial regulatory system affects many processes: cellular metabolism, mitochondrial functions, epigenetic regulation, DNA repair and more. As is expected, the activity of sirtuin proteins affects the manifestation of classic signs of aging in the body, such as cellular senescence, metabolic disorders, mitochondrial dysfunction, genomic instability, and the disruption of epigenetic regulation. …”
Get full text
Article -
106
Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening
Published 2025-01-01“…Protein arginine methyltransferases (PRMTs) play crucial roles in gene regulation, signal transduction, mRNA splicing, DNA repair, cell differentiation, and embryonic development. …”
Get full text
Article -
107
Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes
Published 2025-01-01“…Nuclear lipids play roles in regulatory processes, such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis. …”
Get full text
Article -
108
Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer
Published 2025-01-01“…As a core component of the cohesin complex, SMC1A was initially recognized for its involvement in chromosomal cohesion and DNA-repair pathways. However, recent studies have unveiled its pivotal role in epithelial–mesenchymal transition (EMT), metastasis, and chemo- and radio-resistance in cancer cells. …”
Get full text
Article -
109
Vitrification affects the post-implantation development of mouse embryos by inducing DNA damage and epigenetic modifications
Published 2025-02-01“…The homologous recombination (NHEJ) is the major DNA repair pathway for vitrified embryos. Vitrification elevated H3K4me2/3, H4K12ac, and H4K16ac levels and reduced m6A modification in blastocysts. …”
Get full text
Article -
110
A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i>
Published 2025-01-01“…The proteins YAP-1 (Yes-associated protein 1) and PARP-1 (Poly-(ADP-ribose)–polymerase-1) have been implicated in this resistance, playing crucial roles in cell proliferation and DNA repair mechanisms, respectively. This study explored the inhibitory potential of natural compounds from <i>Lepidium meyenii</i> (Peruvian Maca) on the YAP-1 and PARP-1 protein systems to develop novel therapeutic strategies for GBM. …”
Get full text
Article -
111
The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria
Published 2025-01-01“…Transcriptome analysis indicated that the transfer of ARGs affects bacterial ion binding, oxidative stress, and energy metabolism processes, while the expression of genes related to cell membrane permeability, DNA repair, bacterial drug resistance, and quorum sensing also increase. …”
Get full text
Article -
112
Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb
Published 2013-01-01“…We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. …”
Get full text
Article -
113
Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA
Published 2025-01-01“…Proteomic analysis revealed that MS275 altered the expression of known pemetrexed targets, as well as several proteins involved in pyrimidine metabolism and DNA repair, which could potentiate pemetrexed cytotoxicity. …”
Get full text
Article -
114
Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers
Published 2025-01-01“…BackgroundStudies have shown that more than half of the human genome expression is affected by circadian rhythms, which includes genes involved in cell cycle control, DNA repair and apoptosis that are critical in cancer biology. …”
Get full text
Article -
115
The Impact of Oleuropein on Cisplatin-Induced Toxicity in Cochlear Cells in Relation to the Expression of Deoxyribonucleic Acid Damage-Associated Genes
Published 2024-05-01“…Some of the DNA damage-associated genes whose expression was upregulated with CDDP were downregulated with OLE–CDDP, while the expression of genes such as Gadd45g and Rev1 was further downregulated. The expression of DNA repair-related Abl1, Dbd2, Rad52, and Trp53 genes was downregulated with CDDP, whereas their expression was upregulated with OLE–CDDP treatment. …”
Get full text
Article -
116
Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome.
Published 2025-01-01“…To dissect the biogenesis of cccDNA, we took advantage of an in vitro rcDNA repair system to precipitate host factors interacting with rcDNA and identified co-precipitated proteins by mass spectrometry. …”
Get full text
Article -
117
p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation
Published 2016-01-01“…The number of radiation-induced γH2AX DNA repair foci was higher in mMSCs kept under normoxia but not in p53−/− cells. …”
Get full text
Article -
118
PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials
Published 2024-01-01“…Poly ADP-Ribose Polymerase inhibitors (PARPi) are novel anti-cancer agents that induce DNA damages and cause cell death in tumor cells with impaired DNA repair, known as the synthetic lethality concept. …”
Get full text
Article -
119
Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients’ FOXP1 and GGT levels
Published 2025-01-01“…Further analysis showed that capecitabine combined with oxaliplatin down-regulated the expression of DNA repair related-proteins and up-regulated the expression of key molecules of the apoptosis pathway, thus enhancing the killing effect of oxaliplatin on gastric cancer cells (P < 0.05). …”
Get full text
Article -
120
Compilation and functional classification of telomere length-associated genes in humans and other animal species
Published 2023-06-01“…Functional analysis has shown that telomere length can be influenced by genetic variants in the genes encoding: (1) structural components of telomerase; (2) the protein components of telomeric regions (shelterin and CST complexes); (3) the proteins involved in telomerase biogenesis and regulating its activity; (4) the proteins that regulate the functional activity of the shelterin components; (5) the proteins involved in telomere replication and/or capping; (6) the proteins involved in the alternative telomere lengthening; (7) the proteins that respond to DNA damage and are responsible for DNA repair; (8) RNA-exosome components. The human genes identified by several research groups in populations of different ethnic origins are the genes encoding telomerase components such as TERC and TERT as well as STN1 encoding the CST complex component. …”
Get full text
Article