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161
Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L.
Published 2022-07-01“…Correct maintenance of the DNA methylation status is based on the balance of methylation, passive demethylation, and active demethylation. …”
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162
Insights into <i>Solea senegalensis</i> Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration
Published 2025-01-01“…Fish exhibit diverse mechanisms of sex differentiation and determination, shaped by both external and internal influences, often regulated by distinct DNA methylation patterns responding to environmental changes. …”
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163
A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response
Published 2025-01-01“…Significant changes in CNA and DNA methylation were associated with high ZNF32 expression. …”
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164
Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model
Published 2025-02-01“…The administration of CAL and 20E in obese rats significantly increased the percent of total DNA methylation.This is the first in vivo study on this natural ecdysteroid, which may offer new alternatives for treating metabolic diseases. …”
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165
Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery
Published 2021-01-01“…Once during ongoing CP recovery, DEGs relevant to DNA methylation and specific signaling pathways were induced to express. …”
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166
Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease
Published 2019-01-01“…Epigenetic modifications, such as noncoding RNA regulation, DNA methylation, and histone modification, can directly or indirectly affect the regulation of tau phosphorylation, thereby participating in AD development and progression. …”
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167
The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape
Published 2016-01-01“…In recent years, accumulating results have shown the potential role of epigenetic mechanisms, including histone modifications, DNA methylation, and microRNAs, in the development of RA. …”
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168
Genetics and Epigenetics of Parkinson's Disease
Published 2012-01-01“…In addition, increasing evidence suggests that epigenetic mechanisms, such as DNA methylation, histone modifications, and small RNA-mediated mechanisms, could regulate the expression of PD-related genes.…”
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169
Computer analysis of regulation of hepatocarcinoma marker genes hypermethylated by HCV proteins
Published 2023-01-01“…Epigenetic changes are known to play an important role in the molecular genetic mechanisms of virus-induced oncogenesis. Aber rant DNA methylation is a mediator of epigenetic changes that are closely associated with the HCC pathogenesis and considered a biomarker for its early diagnosis. …”
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170
Epigenetic «probes» for lung cancer monitoring: LINE-1 methylation pattern in blood- circulating DNA
Published 2015-07-01“…Malignant cell transformation is accompanied by two processes of DNA methylation changes: promoter hypermethylation of specific genes and hypomethylation of retrotransposons. …”
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171
Atherogenic Factors and Their Epigenetic Relationships
Published 2010-01-01“…This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.…”
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172
Epigenetic Dynamics: Role of Epimarks and Underlying Machinery in Plants Exposed to Abiotic Stress
Published 2014-01-01“…We present a lucid review of epigenetic machinery and epigenetic alterations involving DNA methylation, histone tail modifications, chromatin remodeling, and RNA directed epigenetic changes.…”
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173
Curcumin as a Supportive Therapy in Type 2 Diabetic Patients
Published 2024-01-01“…Also, epigenetic regulation of type 2 diabetes is discussed, especially the role of DNA methylation.…”
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174
Longitudinal genetic studies of cognitive characteristics
Published 2020-03-01“…The appropriate correction of epigenetic factors related to environmental differences in cognitive abilities requires to determine the mechanisms of chromatin modifications and variations in DNA methylation. Transposons representing stress-sensitive DNA elements appeared to mediate the environmental influence on epigenetic modifications. …”
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175
ENCODE: A Sourcebook of Epigenomes and Chromatin Language
Published 2013-03-01“…The result of this project has identified a set of new DNA regulatory elements, based on novel relationships among chromatin accessibility, histone modifications, nucleosome positioning, DNA methylation, transcription, and the occupancy of sequence-specific factors. …”
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176
Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
Published 2010-01-01“…Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively.…”
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177
DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice
Published 2025-02-01“…Abstract Chemotherapeutic agents, such as paclitaxel (PTX), induce neuroplastic changes and alter gene expression in the prefrontal cortex (PFC), which may be associated with chemotherapy‐induced pain and negative emotions. Notably, DNA methylation undergoes adaptive changes in neurological disorders, emerging as a promising target for neuromodulation. …”
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178
Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis
Published 2015-01-01“…This novel methodology, based on BEL, enables us to integrate epigenetic modifications such as DNA methylation or acetylation of histones into a specific disease network. …”
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179
Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
Published 2016-01-01“…Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.…”
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180
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
Published 2025-01-01“…Epigenetic mechanisms, including DNA methylation, histone tail modifications, and the activity of non-coding RNAs, are strongly implicated in the pathogenesis of neurodegenerative diseases. …”
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