How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health by Ayazhan Akhatova, Celine Jones, Kevin Coward, Marc Yeste

“…Abstract Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. …”
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Single-cell analysis of Mycobacterium tuberculosis with diverse drug resistance using surface-enhanced Raman spectroscopy (SERS) by Andrey Zyubin, Anastasia Lavrova, Marine Dogonadze, Evgenii Borisov, Eugene B. Postnikov

“…The latter is focused on the spectral bands, which correspond to a set of glutathione bands and DNA methylation patterns revealed due to 5-methylcytosine spectral biomarkers. …”
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Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…<h4>Background</h4>Epigenetic modifications, such as DNA methylation and histone modifications, are pivotal in regulating gene expression pathways related to inflammation and cancer. …”
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Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

“…ALA increased DNA demethylase, HMTs, and HATs while decreasing global DNA methylation, DNMT, HDMs, and HDACs mRNA expression/activity in all cervical cancer cell lines. …”
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Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma by Patrick Pearson, Kendra Smith, Nilita Sood, Elizabeth Chia, Alicia Follett, Michael B. Prystowsky, Simon Kirby, Thomas J. Belbin

“…Results In 20 patients from the TCGA cohort of HNSCC patients where ZNF154 and ZNF132 DNA methylation and RNA expression could be compared in tumor and adjacent normal tissue, there was increased DNA methylation and decreased expression of both ZNF154 and ZNF132 in primary tumours. …”
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A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data reveal... by Zhou An, Meichun Zeng, Xianhua Wang

“…By incorporating consistent summary data-based Mendelian randomization associations between DNA methylation and smoke/Barrett’s esophagus, gene expression and smoke/Barrett’s esophagus, and DNA methylation and gene expression, we identified that the genetic variant-cg00935895-RBM43 (ENSG00000184898)-smoke/Barrett’s esophagus axis exerted an effect on smoke/Barrett’s esophagus by altering the DNA methylation level, which regulated the expression level of RBM43. …”
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EpigenomeViewer: A Shiny Web Application for Visualizing Methylation Patterns Across Biological Samples by Nurul Syakima Ab Mutalib

“…DNA methylation plays a crucial role in gene regulation and is involved in the development of numerous diseases including cancer. …”
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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease by Zhihao Qi, Quan Li, Shuhua Yang, Chun Fu, Burong Hu

“…<b>Methods:</b> Summary statistics from expression quantitative trait loci (eQTL), DNA methylation QTL (mQTL), and protein QTL (pQTL) on European descent were included. …”
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Decoding the Methylation Patterns of ABC Transporters in Colorectal Cancer by Nurul Nabilah Norhisan, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Yew Fu Tieng, Imilia Ismail, Muhammad-Redha Abdullah-Zawawi, Learn-Han Lee, Nurul Syakima Ab Mutalib

“…The molecular mechanisms that drive CRC, particularly the DNA methylation patterns in ATP-binding cassette (ABC) genes, have attracted considerable attention because of their potential roles in CRC drug resistance, initiation, and progression. …”
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Supplementation with serine-enriched non-essential amino acids from minimum essential medium promotes blastocyst development of in vitro-fertilized bovine embryos by Nobuhiko ITAMI, Yuji HIRAO

“…Non-essential amino acids (NEAAs) are widely used for the culture of bovine embryos fertilized in vitro; however, the necessity and optimal concentration of individual NEAA must be verified to produce four-criteria-compliant blastocysts. DNA methylation is a critical event for blastocyst formation in bovines, and serine is a common NEAA that serves as a methyl donor and participates in DNA methylation. …”
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Epigenetic Markers of Renal Function in African Americans by Samantha M. Bomotti, Jennifer A. Smith, Alicia L. Zagel, Jacquelyn Y. Taylor, Stephen T. Turner, Sharon L. R. Kardia

“…Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. …”
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Role of Epigenetics in Modulating Phenotypic Plasticity against Abiotic Stresses in Plants by Fayaz Ahmad Dar, Naveed Ul Mushtaq, Seerat Saleem, Reiaz Ul Rehman, Tanvir Ul Hassan Dar, Khalid Rehman Hakeem

“…The variation in DNA methylation in different organisms exhibits variable phenotypic responses. …”
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Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts by Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni

“…P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT. …”
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Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus by Lei Wang, Feng Ding, Shaojie Shi, Xingxing Wang, Sijia Zhang, Yingliang Song

“…This phenomenon may be related to changes in osteogenesis-related gene expression caused by DNA methylation. In this study, we established T2DM models to extract adipose-derived stem cells (ASCs) for different gene identifications through DNA methylation sequencing. …”
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Neighborhood environment associations with cognitive function and structural brain measures in older African Americans by Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

“…We did not find evidence that DNA methylation mediates the observed associations between neighborhood characteristics and cognitive function. …”
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Effects of endocrine disrupting chemicals, blood metabolome, and epigenetics on breast cancer risk: A multi-dimensional mendelian randomization study by Ningning Song, Xinquan Xi, Kuan Yang, Chongzhe Pei, Lingzhou Zhao

“…The study also examines the 1400 blood metabolome as potential mediators and explores EDCs-associated DNA methylation changes as potential factors, with a focus on European populations. …”
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Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells by Adele Murrell

“…Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. …”
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Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence by Valentina Gonzalez-Jaramillo, Eliana Portilla-Fernandez, Marija Glisic, Trudy Voortman, Mohsen Ghanbari, Wichor Bramer, Rajiv Chowdhury, Tamar Nijsten, Abbas Dehghan, Oscar H. Franco, Jana Nano

“…Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. …”
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Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…Although changes in aberrant DNA methylation play a major role in the pathogenesis of most ocular diseases, histone modifications are seldom investigated. …”
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Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis by Anqi Wang, Sitong Yan, Weijia Jiang, Xiang Chen, Yuhan Huang, Xiangyu Zu, Xiao Du, Lulu Fan, Jiatao Liu, Guoping Sun

“…Furthermore, the DNA methylation pattern of CLIP4 was found to have significant prognostic value. …”
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