Insights on the utilisation of tissue culture to aid new breeding techniques for cowpea (Vigna unguiculata L.) improvement by Malizukiswe Vincent Vacu, Promise Sifiso Nzama, Muyiwa Seyi Adegbaju

“…New breeding techniques (NBTs), including gene editing tools, single base pair alterations, and DNA methylation methods, offer promising alternatives to accelerate cowpea improvement. …”
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Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age by T. Ząbek, E. Semik-Gurgul, T. Szmatoła, A. Gurgul, A. Fornal, M. Bugno-Poniewierska

“…In the recent years, the research on aging includes studies of age-related epigenetic effects observed on the DNA methylation level. We applied reduced representation bisulfite sequencing (RRBS) to uncover a range of age DMR sites in genomes of blood leukocytes derived from juvenile and aged horses of native Hucul breed. …”
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The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells by Katarína Smolková, Petr Ježek

“…Arg172 mutants of human IDH2—frequently found with similar mutants of cytosolic IDH1 in grade 2 and 3 gliomas, secondary glioblastomas, and acute myeloid leukemia—catalyze reductive carboxylation of 2-oxoglutarate and reduction to D-2-hydroxyglutarate, which strengthens the neoplastic phenotype by competitive inhibition of histone demethylation and 5-methylcytosine hydroxylation, leading to genome-wide histone and DNA methylation alternations. D-2-hydroxyglutarate also interferes with proline hydroxylation and thus may stabilize hypoxia-induced factor α.…”
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Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort by Thorarinn Gislason, Torben Sigsgaard, Vivi Schlünssen, Joachim Heinrich, Jesús Martínez-Moratalla, Øistein Svanes, Mathias Holm, Bertil Forsberg, Dan Norbäck, Rain Jogi, Kjell Torén, Deborah Jarvis, Magnus Ekström, Adrian Lowe, Caroline J Lodge, Michael Abramson, Shyamali Dharmage, Kathrine Pape, Cecilie Svanes, Gita Mishra, Caroline Lodge, Lyle Gurrin, Bruce Thompson, Eva Lindberg, Christer Janson, Simone Accordini, Ane Johannessen, Bryndis Benediktsdottir, Karl Franklin, Andrei Malinovschi, Anna Oudin, Francisco Gómez Real, José Luis Sánchez-Ramos, Lennart Bråbäck, Torgeir Storaas, Shanshan Xu, Julia Dratva, John Holloway, Jorunn Kirkeleit, Christine Cramer, Gro Tjalvin, Anne Mette Lund Würtz, Randi Jacobsen Bertelsen, Oskar Jõgi, Signe Timm, Francisco Javier Callejas, Raúl Godoy, Trude Duelien Skorge, Christine Drengenes, Nils Oskar Jõgi, Maryia Khomich, Toril Mørkve Knudsen, Ingrid Kuiper, Juan Pablo López-Cervantes, Marianne Lønnebotn, Shokouh Makvandi-Nejad, Antonio Pérez, Anders Røsland, Rajesh Shigdel, Svein Magne Skulstad, Kai Triebner, Hilde Vindenes, Jose Luis Sanchez, Jose Maldonado, David Martino, Jennifer Perret, Lucia Calciano, William Horsnell, Susanne Krauss-Etchmann

“…Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through impact on offspring DNA methylation.Future plans Follow-up is planned at 5–8 years intervals, first in 2021–2023. …”
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Mechanism of Repeat-Associated MicroRNAs in Fragile X Syndrome by Karen Kelley, Shin-Ju E. Chang, Shi-Lung Lin

“…Our studies showed that ramRNA-induced DNA methylation of the FMR1 5′-UTR CGG trinucleotide repeat expansion is responsible for both pathological and neurocognitive characteristics linked to the transcriptional FMR1 gene inactivation and the deficiency of its protein product FMRP. …”
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Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells by Chang Pyo Hong, Moon Kyung Choe, Tae-Young Roh

“…Chromatin structure and dynamics that are influenced by epigenetic marks, such as histone modification and DNA methylation, play a crucial role in modulating gene transcription. …”
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Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations by Stephanie E. King, Nicola A. Schatz, Olena Babenko, Yaroslav Ilnytskyy, Igor Kovalchuk, Gerlinde A. S. Metz

“…Using a systems biology approach, comprehensive DNA methylation (DNAm), miRNA, and mRNA profiling revealed a moderate impact of PNMS in the F1 generation, but drastic changes in F2 and F3 generations, suggesting compounding effects of PNMS with each successive generation. …”
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Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression by Cyprien A. Rivier, Natalia Szejko, Daniela Renedo, Santiago Clocchiatti-Tuozzo, Shufan Huo, Adam de Havenon, Hongyu Zhao, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone

“…Epigenetic age, derived from DNA methylation data, provides a more nuanced representation of aging-related biological processes. …”
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Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…To determine the impact of TICAM2 ablation on innate epigenetic memory in sepsis, we measured genome-wide DNA methylation in bone marrow monocytes and found that Ticam2 -/- cells exhibit a unique profile of altered methylation at CEBPE binding sites and regulatory features for key immune genes such as Dmkn and Btg1. …”
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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to investigate the response of a representative panel of GBM patient-derived cancer stem cells (CSCs) to astrocytic differentiation and RT and TMZ treatments. …”
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LASSO–MOGAT: a multi-omics graph attention framework for cancer classification by Fadi Alharbi, Aleksandar Vakanski, Murtada K. Elbashir, Mohanad Mohammed

“…This article introduces Least Absolute Shrinkage and Selection Operator–Multi-omics Gated Attention (LASSO–MOGAT), a novel graph-based deep learning framework that integrates messenger RNA, microRNA, and DNA methylation data to classify 31 cancer types. By utilizing differential expression analysis (DEG) with Linear Models for Microarray (LIMMA) and LASSO regression for feature selection and leveraging graph attention networks (GATs) to incorporate protein–protein interaction (PPI) networks, LASSO–MOGAT effectively captures intricate relationships within multi-omics data. …”
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Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective by Stephanie A. Fernandes, Andrew G. L. Douglas, Miguel A. Varela, Matthew J. A. Wood, Yoshitsugu Aoki

“…Two basic mechanisms have been proposed as being potentially responsible for c9FTD/ALS: loss-of-function of the protein encoded by this gene (associated with aberrant DNA methylation) and gain of function through the formation of RNA foci or protein aggregates. …”
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Chromosome-scale telomere to telomere genome assembly of common crystalwort (Riccia sorocarpa Bisch.) by Katarzyna Krawczyk, Joanna Szablińska-Piernik, Łukasz Paukszto, Mateusz Maździarz, Paweł Sulima, Jerzy Andrzej Przyborowski, Monika Szczecińska, Jakub Sawicki

“…Moreover, collinearity of Marchantiales was analyzed as well as gene family evolution and DNA methylation profile. The availability of this genome, which is the second telomere-to-telomere liverwort assembly, opens up new avenues for in-depth analysis of R. sorocarpa genetic diversity and genomic characteristics.…”
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Breeding for postharvest physiological deterioration in cassava: problems and strategies by Wilton Mbinda, Asunta Mukami

“…Continuous improvements based on the new plant breeding technologies (genome editing, speeding breeding and RNA-dependent DNA methylation) in cassava and innovations in postharvest handling and storage of the storage roots are expected to provide sustainable solutions for PPD constraints and make cassava an important food security and nutrition and industrial crop.…”
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Role of HNF6 in liver homeostasis and pathophysiology by Miaomiao Tian, Weizhen Gao, Shujun Ma, Huiling Cao, Yu Zhang, Fuxiang An, Jianni Qi, Zhen Yang

“…Its expression is affected by epigenetic modifications such as DNA methylation, post-translational modifications, and microRNAs. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…Epigenetic alterations, including DNA methylation and histone modifications, are also prevalent in both cancer types. …”
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Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines by Sam Humphries, Sean M. Burnard, Courtney D. Eggins, Simon Keely, Danielle R. Bond, Heather J. Lee

“…HMAs act in a replication-dependent manner to remove DNA methylation from the genome. However, AML cells targeted by HMA therapy are often quiescent within the bone marrow, where oxygen levels are low. …”
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The Fractal Dimension of Nuclear Chromatin as a Prognostic Factor in Acute Precursor B Lymphoblastic Leukemia by Randall L. Adam, Rosana C. Silva, Fernanda G. Pereira, Neucimar J. Leite, Irene Lorand-Metze, Konradin Metze

“…Blasts with lower R2 values, equivalent to accentuated “coarseness” of the chromatin pattern, which may reflect profound changes of the DNA methylation, indicated a poor prognosis. In conclusion the goodness-of-fit of the Minkowski–Bouligand dimension of chromatin can be regarded as a new and biologically relevant prognostic factor for patients with B-ALL.…”
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Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis by Qian Guo, Xinxin Zhong, Zihan Dang, Baiquan Zhang, Zixin Yang

“…Mutations, somatic copy number alterations, and DNA methylation lead to its aberrant expression. GBN5 expression is associated with many clinical features. …”
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Liberties of the genome: insertions of mitochondrial DNA fragments into nuclear genome by M. V. Golubenko, V. P. Puzyrev

“…Partial copies of mitochondrial DNA in the human nuclear genome can interfere with mtDNA during experimental studies of the mitochondrial genome, such as genotyping, heteroplasmy assessment, mtDNA methylation analysis, and mtDNA copy number estimation. …”
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