Unique ultrastructural organization of human rod photoreceptors by Tylor R. Lewis, Natalia V. Klementieva, Sebastien Phan, Carson M. Castillo, Keun-Young Kim, Lauren Y. Cao, Mark H. Ellisman, Vadim Y. Arshavsky, Oleg Alekseev

“…These structures have two striking features: they are reinforced by a massive microtubular cytoskeleton and contain electron-dense adhesions that mediate their attachment to outer segments. …”
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Intracellular pressure controls the propagation of tension in crumpled cell membranes by Raviv Dharan, Avishai Barnoy, Andrey K. Tsaturyan, Alon Grossman, Shahar Goren, Inbar Yosibash, Dikla Nachmias, Natalie Elia, Raya Sorkin, Michael M. Kozlov

“…Here, we propose, analyze theoretically, and support experimentally a mechanism of tension propagation in membranes crumpled by the contractile cortical cytoskeleton. The tension spreading is mediated by the membrane flow between the crumples. …”
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Characterization of the C-terminal tail of the Arc protein. by Melissa Boldridge, Jody Shimabukuro, Keith Nakamatsu, Christian Won, Chad Jansen, Helen Turner, Lei Wang

“…The activity-regulated cytoskeleton-associate protein Arc (or Arg3.1) is specifically linked to memory formation and a number of cognitive disorders, including Alzheimer's disease and schizophrenia. …”
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Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa by Ikue Shibasaki, Hinata Sugiyama, Yuko Kamada, Hiroaki Nagatomo, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Tsuyoshi Kasai, Takashi Kohda, Teruhiko Wakayama

“…By depolymerizing the cytoskeleton of blastomeres with cytochalasin B and colcemid, some micronuclei could be extracted from blastomeres of ACS embryos using a glass needle of a micromanipulator. …”
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Elastic Membrane That Undergoes Mechanical Deformation Enhances Osteoblast Cellular Attachment and Proliferation by G. K. Toworfe, R. J. Composto, M. H. Lee, P. Ducheyne

“…Upon application of a mechanical force to cells cultured on the functionalized silicone membrane in the form of a dynamic equibiaxial strain, 2% magnitude; at 1-Hz frequency for 2 h, the osteoblast cells elicited slightly elevated phalloidin fluorescence, suggesting that there was reorganization of the cytoskeleton. We concluded from this preliminary data obtained that the engineered surface transduced applied mechanical forces directly to the adherent osteoblast cells via integrin binding tripeptide receptors, present in the FN molecules, resulting in the enhanced cellular attachment and proliferation.…”
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Fortilin binds CTNNA3 and protects it against phosphorylation, ubiquitination, and proteasomal degradation to guard cells against apoptosis by Mari Nakashima, Decha Pinkaew, Uttariya Pal, Fei Miyao, Hanna Huynh, Lena Tanaka, Ken Fujise

“…Although fortilin has been shown to interact with cytoskeleton proteins such as tubulin and actin, its interactions with the components of adherens junctions remained unknown. …”
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Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer by Can Wu, Xiao Wei Zhang, Manman Wang, Jinpan Sun, Jianfei Chen, Yanbin Guan, Xin Pang

“…After nanofiber disassembly, the released 1-Pept converts into Pept under the catalysis of intracellular overexpressed trypsin, which then reassembles into denser Pept NFs, inducing a cascade of effects including disruption of the cytoskeleton, mitochondrial dysfunction, and activation of caspase-3. …”
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Exploring the prognosis of calponin h1 in carcinogenesis: A novel target in biomedical research by Roshna Sankar, Sharon John, Priya Devi, Sameer Gupta, Shalini Gupta

“…H1 calponin is primarily involved in maintaining blood vessel integrity and controlling smooth muscle contraction, in the cytoskeleton. Stromal myofibroblasts play a crucial role in tumor invasion and metastasis by their capacity to alter the extracellular matrix. …”
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An antagonistic role of clock genes and lima1 in kidney regeneration by Xian He, Ziming Wang, Linxi Cheng, Han Wang, Yuhua Sun

“…In per1a and nr1d1 mutants, the expression of RPC genes and the number of RPCs were decreased, resulting in a marked delay in nephron regeneration. lima1a, which encodes a cytoskeleton binding protein that functions to negatively regulate epithelial to mesenchymal transition (EMT), is identified as the direct target of the clock proteins. …”
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Deletion of a Putative GPI-Anchored Protein-Encoding Gene Aog185 Impedes the Growth and Nematode-Trapping Efficiency of Arthrobotrys oligospora by Disrupting Transmembrane Transpor... by Hui Peng, Hengqian Lu, Xinyuan Dong, Xiao Liang, Kangliang Sheng, Jingmin Wang, Xiaowei Kong, Xiangdong Zha, Yongzhong Wang

“…Aog185 deletion could damage the intrinsic components of the membrane and cytoskeleton. Specifically, knockout of Aog185 disrupted transmembrane transport homeostasis during the phagocytosis, cell autophagy, and oxidative phosphorylation processes, which were associated with the fusion of cells and organelle membranes, transport of ions and substrates, and energy metabolism. …”
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Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis by Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, Halis Akalın, Guher Goral, Haluk Barbaros Oral

“…The differentially expressed miRNAs and their predicted target genes involved in endocytosis, regulation of actin cytoskeleton, MAPK signaling pathway, and cytokine-cytokine receptor interaction and its chemokine signaling pathway indicate their potential roles in chronic brucellosis and its progression. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…By regulating downstream signaling pathways such as NF-κB, MAPK/ERK, PI3K/AKT, TGF-β, and Wnt/β-catenin, GPCRs also upregulate mesenchymal transcription factors including Snail, ZEB, and Twist superfamilies which regulate cell polarity, cytoskeleton remodeling, migration, and invasion. Likewise, ERS-induced UPR upregulates gene transcription and expression of proteins related to EMT enhancing tumor aggressiveness. …”
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Neurotensin is a Versatile Modulator of In Vitro Human Pancreatic Ductal Adenocarcinoma Cell (PDAC) Migration by Tatjana Mijatovic, Philippe Gailly, Véronique Mathieu, Nancy De Nève, Paul Yeaton, Robert Kiss, Christine Decaestecker

“…Neurotensin both induced altered expression of αV and β5 integrin subunits in PDACs cultured on vitronectin resulting in modified adhesion abilities, and caused modifications to the organization of the actin cytoskeleton through the NT-mediated activation of small Rho GTPases. …”
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Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis by Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu

“…Significant KEGG pathway enrichment included ribosome biogenesis in eukaryotes, RNA transport, proteoglycans in cancer, dilated cardiomyopathy, rheumatoid arthritis, vascular smooth muscle contraction, focal adhesion, regulation of the actin cytoskeleton, and hypertrophic cardiomyopathy. The PPI network identified 10 hub genes including HSP90AA1, CDC5L, MDM2, LRRK2, CFTR, IQGAP1, CAND1, TOP2A, DDX21, and HIF1A. …”
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The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum by Lucija Mijanović, Darija Putar, Lucija Mimica, Sabina Klajn, Vedrana Filić, Igor Weber

“…To attach to the extracellular matrix (ECM), mammalian cells form integrin adhesion complexes consisting of many proteins that together link the ECM and the actin cytoskeleton. Similar to mammalian cells, the amoeboid cells of the protist Dictyostelium discoideum also use multiprotein adhesion complexes to control their attachment to the underlying surface. …”
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Transient ocular hypertension remodels astrocytes through S100B. by Weiran Huang, Kenji Matsushita, Rumi Kawashima, Susumu Hara, Yuichi Yasukura, Kaito Yamaguchi, Shinichi Usui, Koichi Baba, Andrew J Quantock, Kohji Nishida

“…Glial fibrillary acidic protein (GFAP), S100B, and actin staining were used to characterize astrocyte morphology and cytoskeleton, with qPCR used to measure mRNA expression. …”
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The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment. by William R Hardin, Germain C M Alas, Nikita Taparia, Elizabeth B Thomas, Melissa C Steele-Ogus, Kelli L Hvorecny, Aaron R Halpern, Pavla Tůmová, Justin M Kollman, Joshua C Vaughan, Nathan J Sniadecki, Alexander R Paredez

“…This work supports the emerging view that Giardia's unconventional actin cytoskeleton has an important role in supporting parasite attachment.…”
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Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria by I. V. Leppyanen, A. N. Kirienko, A. A. Lobov, E. A. Dolgikh

“…They may be involved in the regulation of reactions with calcium, the reorganization of the actin cytoskeleton and other important processes in plants. …”
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Activity of Various Cathepsin Proteases and Enrichment of Klotho Protein in the Urine and Urinary Extracellular Vesicles After SARS-CoV-2 Infection by Niharika Bala, Ramish H. Rafay, Sarah C. Glover, Abdel A. Alli

“…The identified proteins were predominantly associated with cellular membranes and with function of the cytoskeleton, enzyme regulation, and signal transduction. …”
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Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures by Yán Wāng

“…Although PM2.5 primarily affects the nucleus, cytoskeleton, mitochondria, endoplasmic reticulum, and lysosomes, other organelles like ribosomes, Golgi apparatus, and peroxisomes have received limited attention. …”
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