Regulators of Actin Dynamics in Gastrointestinal Tract Tumors by Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald

“…Reorganization of the actin cytoskeleton underlies cell migration in a wide variety of physiological and pathological processes, such as embryonic development, wound healing, and tumor cell invasion. …”
Get full text

The symbiotic origin of the eukaryotic cell by López-García, Purificación, Moreira, David

“…For several decades, the most accepted scenario involved the evolution of an independent lineage of proto-eukaryotes endowed with an endomembrane system, including a nuclear compartment, a developed cytoskeleton and phagocytosis, which engulfed the alphaproteobacterial ancestor of mitochondria. …”
Get full text

Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces by L. Feller, R. A. G. Khammissa, I. Schechter, G. Thomadakis, J. Fourie, J. Lemmer

“…Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. …”
Get full text

Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells by G. A. Martens

“…The core proteomes of human and rat pancreatic beta cells were compared by label-free LC-MS/MS: this resulted in quantification of relative molar abundances of 707 proteins belonging to functional pathways of intermediary metabolism, protein synthesis, and cytoskeleton. Relative molar abundances were conserved both within and between pathways enabling the selection of a housekeeping network for geometric normalization and the analysis of potentially relevant differential expressions. …”
Get full text

The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degener... by Lisa Schwarz, Grit Vollmer, Christiane Richter-Landsberg

“…The group of small HSPs, namely, HSP27 and αB-crystallin, interact with the cytoskeleton, bind to nonnative proteins, and prevent their aggregation after stress. …”
Get full text

A mathematical model of mechanotransduction by Bradley J. Roth

“… This article reviews the mechanical bidomain model, a mathematical description of how the extracellular matrix and intracellular cytoskeleton of cardiac tissue are coupled by integrin membrane proteins. …”
Get full text

Integrative machine learning frameworks to uncover specific protein signature in neuroendocrine cervical carcinoma by Tao Shen, Tingting Dong, Haiyang Wang, Yi Ding, Jianuo Zhang, Xinyi Zhu, Yeping Ding, Wen Cai, Yalan Wei, Qiao Wang, Sufen Wang, Feiyun Jiang, Bin Tang

“…These kNsDEPs play a central role in cytoskeleton protein binding and showcase robust diagnostic ability and specificity for NECC. …”
Get full text

Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways by W. Nie, A. M. Deters

“…Independent of cell type TSw marginally regulated the expression of genes, which referred to membrane proteins, cytoskeleton, cytokine signaling, and ECM as well as to processes of metabolism and transcription. …”
Get full text

The Desmosomal Plaque Proteins of the Plakophilin Family by Steffen Neuber, Mario Mühmer, Denise Wratten, Peter J. Koch, Roland Moll, Ansgar Schmidt

“…These proteins have been implicated in cell signaling, organization of the cytoskeleton, and control of protein biosynthesis under specific cellular circumstances. …”
Get full text

Vesicles Generated during Storage of Red Blood Cells Enhance the Generation of Radical Oxygen Speciesin Activated Neutrophils by Herbert Jank, Ulrich Salzer

“…This uptake is different from a phagocytotic process and is enhanced upon interference with the cellular actin cytoskeleton. Preincubation of neutrophils with Vsto vesicles results in an enhanced ROS generation by neutrophils, which is further increased upon fMLP stimulation and during zymosan phagocytosis. …”
Get full text

Integrin-Linked Kinase: A Multi-functional Regulator Modulating Extracellular Pressure-Stimulated Cancer Cell Adhesion through Focal Adhesion Kinase and AKT by Shouye Wang, Marc D. Basson

“…The siRNA-mediated loss of function of ILK in regulating increase in adhesion by pressure was not rescued by overexpression of α-parvin, an important ILK binding partner, although pressure promoted ILK–α-parvin association and translocated both ILK and α-parvin from cytosol to membrane/cytoskeleton. ILK may be a key mediator of mechanotransduced signals in cancer cells and an important therapeutic target to inhibit metastatic cancer cell adhesion.…”
Get full text

Unraveling the Determinants of Protrusion Formation by Mita Varghese, Peter Gorsevski, Marilyn L. Cayer, Nancy S. Boudreau, Carol A. Heckman

“…We conclude that cells establish functional domains by rearranging the cytoskeleton.…”
Get full text

Genotype-phenotype insights of pediatric dilated cardiomyopathy by Ying Dai, Yan Wang, Youfei Fan, Bo Han

“…Research has shown that DCM exhibits notable genetic heterogeneity, with over 100 DCM-related genes identified to date, primarily involving functions such as calcium handling, the cytoskeleton, and ion channels. As human genomic variations are linked to phenotypes, DCM phenotypes are influenced by numerous genetic variations across the entire genome. …”
Get full text

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease by Tung D. Nguyen, Michael A. Winek, Mihir K. Rao, Shaiva P. Dhyani, Monica Y. Lee

“…Studies implicate nucleoskeletal elements (e.g. nuclear lamina) and the linker of nucleoskeleton and cytoskeleton (LINC) complex in force transmission, emphasizing nucleo-cytoskeletal communication in mechanotransduction. …”
Get full text

Tight junction proteins in glial tumors development and progression by Jakub Moskal, Slawomir Michalak, Slawomir Michalak

“…Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tight junction-associated Marvel protein family, junctional adhesion molecule family, and proteins that anchor the cytoskeleton, such as zonula occludens proteins and the cingulin family. …”
Get full text

Exogenous LEA proteins expression enhances cold tolerance in mammalian cells by reducing oxidative stress by Martina Lo Sterzo, Domenico Iuso, Luca Palazzese, Margherita Moncada, Francesca Boffa, Aurora Scudieri, Luisa Gioia, Marta Czernik, Pasqualino Loi

“…Their protective action was due to the mitigation of cold-induced mitochondrial stress and the overproduction of reactive oxygen species (ROS), leading in turn to enhanced cytoskeleton stability and decreased DNA damage. Our studies showed that plant-derived LEA proteins exhibit remarkable cold protection effects in mammalian cells through their potent antioxidant properties, which was found comparable to Vitamin E.…”
Get full text

Longitudinal growth of the Saccharina kelp embryo depends on actin filaments that control the formation of a corset-like structure composed of alginate by Samuel Boscq, Ioannis Theodorou, Roman Milstein, Aude Le Bail, Sabine Chenivesse, Bernard Billoud, Bénédicte Charrier

“…Thus, in addition to revealing the existence of a mannuronate-rich alginate corset-like structure that may restrict the enlargement of the zygote and the embryo, thereby promoting the formation of the apico-basal growth axis, we demonstrate stage- and cytoskeleton-dependent differences in cell wall deposition in Saccharina embryos.…”
Get full text

Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…The role of mechanisms such as alterations in the actin cytoskeleton, oxidative stress, mitochondrial dysfunction, and inadequate autophagy within the microenvironment of podocyte injury have garnered increasing attention. …”
Get full text

Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? by Simone Steinbach, Mariana Molina, Lea T Grinberg, Luisa Aring, Annika Guntermann, Katrin Marcus, Helmut Heinsen, Renata E Paraizo Leite, Caroline May

“…These proteins are associated with the cytoskeleton, neuronal plasticity, or calcium homeostasis. …”
Get full text

Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets. by Yuan Tian, Nicolette Heinsinger, Yinghui Hu, U-Ming Lim, Yi Wang, Aaron Zefrin Fernandis, Sophie Parmentier-Batteur, Becky Klein, Jason M Uslaner, Sean M Smith

“…Multiple interactome proteins were differentially regulated by TDP-43 overexpression and toxicity, including those involved in RNA regulation, cell survival, cytoskeleton reorganization, protein modification, and diseases. …”
Get full text