Artificial Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure: Systematic Review and Meta-Analysis by Robert S. Brown, Jr, MD, MPH, Robert A. Fisher, MD, FACS, TACC, Ram M. Subramanian, MD, MBA, Adam Griesemer, MD, Milene Fernandes, PharmD, MSc, William H. Thatcher, MS, Kathryn Stiede, BS, Michael Curtis, PhD

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Heterogeneity of Intermediate Care Organization Within a Single Healthcare System by Aaron S. Case, MD, MHS, Chad H. Hochberg, MD, MHS, Binu Koirala, PhD, MGS, BSN, RN, Eleni Flanagan, DNP, MBA, Souvik Chatterjee, MD, William N. Checkley, MD, PhD, Ayse P. Gurses, PhD, MS, MPH, David N. Hager, MD, PhD

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The Complete Blood Count Sepsis Index Using Monocyte Distribution Width for Early Detection of Sepsis in Patients Without Obvious Signs by Scott Levin, PhD, Nima Sarani, MD, Jeremiah Hinson, MD, PhD, Melissa Naiman, PhD, Chad Cannon, MD, Aria Smith, MS, Benjamin Steinhart, MS, Arnaud DeBraine, BS, Sarah Kehoe, PhD, Bryan Immhoff, MD, Yasir Taribichi, MD, Alexandra Malinovska, MD, Kemi Badaki-Makun, MD

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Composite Primary Outcomes Reported in Studies of Critical Care: A Scoping Review by Prashanti Marella, MD, Sansuka De Silva, Antony G. Attokaran, Kevin B. Laupland, PhD, Lars Eriksson, BA, Mahesh Ramanan, MMed

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Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children by Yudy Fonseca, MD, Alise Davies, PA, Stephanie Jarrin, MD, Liliana Simon, MD, Cortney Foster, DO, Sun Kai, Adnan Bhutta, MD

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Evaluating the Adequacy of Central Line-Associated Bloodstream Infection As a Quality Measure: A Cross-Sectional Analysis at a Single Tertiary Care Center by Piyush Mathur, MD, FCCM, FASA, FAMIA, Amanda J. Naylor, MD, MPH, Moises Auron, MD, Jean Beresian, MD, Alexandra Tallman, BSN, RN, SANE-A, Allison Griffith, MSN, RN, CCRN, CPHQ, Kathleen Seasholtz, BSN, RN, HACP, Mariel Manlapaz, MD, Katherine Zacharyasz, MSN, RN, CPHQ, Reem Khatib, MD, MBA, FASA, Shreya Mishra, PhD, Kathryn Haller, PA, Thomas Fraser, MD, Katherine Holman, MD

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Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

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A Retrospective, Single-Center Assessment of Changes in Pain, Agitation, and Delirium Management Before and During the COVID-19 Pandemic by Rachel L. Winner, PharmD, BCCCP, Lydia R. Ware, PharmD, BCPS, BCCCP, Kevin M. Dube, PharmD, BCPS, BCCCP, Mary P. Kovacevic, PharmD, BCPS, BCCCP, Kenneth E. Lupi, PharmD, BCPS, BCCCP, Paul M. Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS, Jeremy R. DeGrado, PharmD, BCCCP

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Luciano Gattinoni—A Fond and Grateful Remembrance by John J. Marini, MD

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Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients by Sarah A. Teele, MD, MSHPEd, Avihu Z. Gazit, MD, Craig Futterman, MD, William G. La Cava, PhD, David S. Cooper, MD, MPH, MBA, Steven M. Schwartz, MD, MS, Joshua W. Salvin, MD, MPH

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Three-Dimensional Electrical Impedance Imaging During Spontaneous Breathing Trials in Patients With Acute Hypoxic Respiratory Failure: A Pilot Study by Nilton Barbosa da Rosa, Jr, MS, Tzu-Jen Kao, MD, PhD, John Brinton, PhD, Patrick J. Offner, Ellen L. Burnham, MD, Jennifer L. Mueller, PhD

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Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children by Thomas C. Seijbel, BSc, Levi Hoste, MD, Corinne M. P. Buysse, MD, PhD, Karolijn Dulfer, PhD, Filomeen Haerynck, MD, PhD, Matthijs de Hoog, MD, PhD, Naomi Ketharanathan, MD, PhD

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Representation of Hispanic Patients in Clinical Trials for Respiratory Failure: A Systematic Review by Emily A. Harlan, MD, MA, MSc, Kaitlin Malley, BS, Grecia Quiroga, MD, Eman Mubarak, MD, Pema Lama, BS, Amanda Schutz, PhD, Adolfo Cuevas, PhD, Catherine L. Hough, MD MSc, Theodore J. Iwashyna, MD PhD, Mari Armstrong-Hough, PhD, Thomas S. Valley, MD, MSc

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