A randomized controlled study of auricular point acupressure to manage chemotherapy-induced neuropathy: Study protocol. by Nada Lukkahatai, Michael V Nguyen, Jingyu Zhang, Yu-Min Cho, Chitchanok Benjasirisan, Heijingzi Monica Jia, Claudia M Campbell, Jennifer Kawi, Hulin Wu, Hongyu Wang, Rupsikha Bora, Johannes Thrul, Constance M Johnson, Thomas J Smith

“…<h4>Trial registration</h4>ClinicalTrials.gov, ID NCT04920097 registered on 3 June 2021.…”
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Development and pilot testing of a nurse-led common-sense model of self-regulation-based heart failure self-care program by Zehao Huang, Sek Ying Chair

“…Trial registration Chinese Clinical Trial Registry (No., ChiCTR2300068156; February 9, 2023).…”
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Proliferative Vitreoretinopathy after Eye Injuries: An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid by Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Mario R. Romano, Ciro Costagliola, Francesco Semeraro

“…This paper reviews the current literature and clinical trial data on the pathogenesis of PVR and its correlation with ocular trauma and describes the biochemical/molecular events that will be fundamental for the development of novel treatment strategies. …”
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In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. by Baback Roshanravan, Sophia Z Liu, Amir S Ali, Eric G Shankland, Chessa Goss, John K Amory, H Thomas Robertson, David J Marcinek, Kevin E Conley

“…Here, we describe the impact of a first-in-class cardiolipin-binding compound that is targeted to mitochondria and improves oxidative phosphorylation capacity (Elamipretide, ELAM) in a randomized, double-blind, placebo-controlled clinical trial.<h4>Methods</h4>Non-invasive magnetic resonance and optical spectroscopy provided measures of mitochondrial capacity (ATPmax) with exercise and mitochondrial coupling (ATP supply per O2 uptake; P/O) at rest. …”
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The effect of telenursing follow-up on blood glycosylated hemoglobin and quality of life in the elderly with diabetes type 2 by Elahe Asadi, Fariba Borhani, Abbas Abbaszadeh

“…Materials and Methods: In this clinical trial study, 90 patients with type 2 diabetes referred to the hospitals affiliated with Shahid Beheshti University of Medical Sciences in 1401–1402 were divided into two control and experimental groups (45 patients in each group) by the simple random sampling method. …”
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Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial by Liana Trugilho, Lívia Alvarenga, Ludmila Cardozo, Bruna Paiva, Jessyca Brito, Isis Barboza, Jonatas Almeida, Juliana dos Anjos, Pramod Khosla, Marcelo Ribeiro-Alves, Denise Mafra

“…This double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the effects of a tocotrienol-rich fraction (TRF) supplementation (300 mg/day) on oxidative stress and inflammatory markers, including transcription factors in nondialysis (ND) and hemodialysis (HD) CKD patients for three months. …”
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The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood by Okko Savonius, Irmeli Roine, Saeed Alassiri, Taina Tervahartiala, Otto Helve, Josefina Fernández, Heikki Peltola, Timo Sorsa, Tuula Pelkonen

“…Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. …”
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Comparison of a ready-to-use intranasal dexmedetomidine spray with traditional intranasal dexmedetomidine drops for sedation in preschool children: a prospective, randomized, contr... by Qi-Qi Jin, Wei-Cha Cai, Ying-Feng Zhou, Yan-Tong Zhang, Gang Chen, Meng-Ting Xu, Jun Li, Kai-Ming Yuan

“…Compliance with induction was comparable, with 53.5% in the DS group and 40.0% in the DD group demonstrating “optimal” compliance.ConclusionBoth intranasal spray and syringe drop methods were highly effective in providing sedation and anxiolysis, but the ready-to-use intranasal dexmedetomidine spray was more acceptable to children, offering a viable alternative to the syringe method.Clinical Trial RegistrationChiCTR.org.cn, identifier ChiCTR2400089374.…”
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Quantitation of Phenolic Compounds Related to Antioxidant and Antiosteoporosis Activities in Ripe and Unripe Maesil (Prunus mume) by Chong Woon Cho, Young Sik Park, Xi-Tao Yan, Hyun June Kim, Young Ho Kim, Kyung Tae Kim, Chu Van Men, Jong Seong Kang

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Sex-Related Differences in the Effects of the Mediterranean Diet on Glucose and Insulin Homeostasis by Alexandra Bédard, Louise Corneau, Benoît Lamarche, Sylvie Dodin, Simone Lemieux

“…Results suggest that the more favorable changes in glucose/insulin homeostasis observed in men compared to women in response to the MedDiet are not explained by sex differences in NEFA response. This clinical trial is registered with clinicaltrials.gov NCT01293344.…”
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Efficacy and safety of high-voltage versus standard-voltage pulsed radiofrequency ablation for patients with neuropathic pain: protocol for a systematic review and meta-analysis by Zheng Wang, Yitong Jia, Yanhui Ma, Tengteng Wang, Kunpeng Feng, Guang Feng, Tianlong Wang

“…This study aims to compare the efficacy and safety of high-voltage PRF ablation and standard-voltage PRF ablation for the treatment of patients with NP.Methods and analysis We will search PubMed/MEDLINE, EMBASE, Web of Science, the Cochrane Library, conference proceedings for relevant abstracts, clinical trials registers (ClinicalTrials.gov) and the WHO’s International Clinical Trial Registry Platform (from the date of inception until 15 March 2022). …”
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The effects of integrated traditional Chinese and western medicine rehabilitation programs on post-acute ankle sprain: A randomized controlled trial study protocol. by Hang Gao, Xiao Chen, Jiayi Ren, Xinglai Zhang, Yuqian Hu, Zhao Ma, Yuanjia Gu, Jiming Tao, Weian Yuan

“…<h4>Trial registration</h4>The trial was registered at Chinese Clinical Trial Registry https://www.chictr.org.cn/showproj.html?…”
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Short-Course Induction Treatment with Intrathecal Amphotericin B Lipid Emulsion for HIV Infected Patients with Cryptococcal Meningitis by Gerardo Alvarez-Uria, Manoranjan Midde, Raghavakalyan Pakam, Pradeep Sukumar Yalla, Praveen Kumar Naik, Raghuprakash Reddy

“…However, the good tolerability of intrathecal administration of AmB lipid emulsion and the clinically important mortality reduction observed with the short-course induction treatment warrant further research, ideally through a randomized clinical trial.…”
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Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. by Ana María Ramos Cedeño, Leslie Pérez Ruiz, Julio Dámaso Fernández Águila, Tamara Guerra, Maritza Cabrera Zamora, Hailen Bobillo López

“…</p><p><strong>Abstract</strong></p><p>To demonstrate the effectiveness of Leukocim an open, phase IV clinical trial was designed, 39 patients from Cienfuegos were evaluated with 73 neutropenic episodes in primary or secondary prophylaxis or treatment, the demographic parameters behaved with an age 49.86 year old average, the predominant sex was the feminine 64.38%, 73.97% belonged to the white race, when the effectiveness was analyzed we obtained that 46.5% received the treatment in an ambulatory way, whereas 52.1% was hospitalized; one patient abandoned before beginning the treatment, the 12,3% of patients abandoned the study, the dose number received in order to correction CAN was between 3 and 7, behaving with a stocking of 1.26 before receiving the treatment and of 5.82 after the same one receiving the next cycle chemo y/o radiotherapy in time demonstrating this way the effectiveness of the product.…”
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Diagnosis of Sleep Apnea Hypopnea Syndrome Using Fusion of Micro-motion Signals from Millimeter-wave Radar and Pulse Wave Data by Xiang ZHAO, Wei WANG, Chenyang LI, Jian GUAN, Gang LI

“…Experimental results of a clinical trial dataset at Shanghai Jiaotong University School of Medicine Affiliated Sixth People’s Hospital demonstrated that the AHI estimated by the proposed approach correlates with the gold standard PSG with a coefficient of 0.93, indicating good consistency. …”
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IoC2 monitoring versus standard practice in reducing opioid consumption in elderly patients undergoing laparoscopic colorectal surgery: a study protocol for a randomised controlled... by Zhe Li, Jing Zhao, Xiaowen Liu, Huamei Cai, Yun Yan

“…The primary outcome will be to compare intraoperative sufentanil consumption between the two groups to assess the potential role of IoC2 in optimising perioperative analgesia in elderly patients.Ethics and dissemination This study has been approved by the ethics committee of China-Japan Friendship Hospital (2024-KY-148-3) and registered in the Chinese Clinical Trial Registry (ChiCTR2400089115). The findings will be disseminated through academic presentations and peer-reviewed journal publications, providing valuable data and insights into the role of IoC2 in guiding intraoperative pain management.Trial registration number ChiCTR2400089115.…”
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Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Owing to gaps between preclinical and clinical studies, nano-immunotherapy faces multiple challenges, including the biosafety of nanomaterials and clinical trial design. In this review, we provide an overview of cancer immunotherapy and summarize the evidence indicating how nanomedicine-based approaches increase the efficacy of immunotherapies. …”
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Effects on Parental Stress of Early Home-Based CareToy Intervention in Low-Risk Preterm Infants by Giuseppina Sgandurra, Elena Beani, Emanuela Inguaggiato, Jakob Lorentzen, Jens Bo Nielsen, Giovanni Cioni

“…This trial is registered with Clinical Trial.gov NCT01990183.…”
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Comparison of the Efficacy and Safety of Temporary Spinal Cord Stimulation versus Pulsed Radiofrequency for Postherpetic Neuralgia: A Prospective Randomized Controlled Trial by Xiaohong Li, Pan Chen, Jian He, Xiang Huang, Dacheng Tang, Lumiao Chen, Xiaoping Wang

“…This study was prospectively registered in the Chinese Clinical Trial Registry (ChiCTR2100050647).…”
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Protocol for visual-acoustic intervention with service delivery in-person and via telepractice (VISIT) non-inferiority trial for residual speech sound disorder by Tara McAllister, Jonathan L. Preston, Elaine R. Hitchcock, Nina R. Benway, Jennifer Hill

“…Trial registration ClinicalTrials.gov identifier NCT06517225, 07/23/2024. …”
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