Metformin increases mammographic breast density: a randomized controlled trial by Sadaf Alipour, Ladan Hosseini, Zohreh Forootan, Hadith Rastad, Leila Bayani, Mahboubeh Abedi, Bita Eslami

“…Conclusions This clinical trial showed that consumption of metformin 500 mg twice daily for 6 months is associated with a higher mammographic breast density as compared to the placebo group. …”
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Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis by Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka

“…A recombinant soluble form of thrombomodulin has been approved to treat patients suffering from disseminated intravascular coagulation (DIC) and has thus far shown greater therapeutic potential than heparin. A phase II clinical trial is currently underway in the USA to study the efficacy of thrombomodulin for the treatment of sepsis with DIC complications. …”
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Ivermectin as a Treatment Modality in COVID-19 Patients: A Systematic Review and Meta-Analysis of Up-To-Date RCTs by Raghava Kalyan Maddukuri, Madhavi Latha Desimalla, Reshma Banavathu, Sai Pavan Kumar Arepalli

“…Literature search was carried out in PubMed, Scopus, and google scholar. Clinical trial registries (clinical trail.gov) and preprint servers (Medrxiv) were also searched for registered and preprint data respectively. …”
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Impact of social support and breastfeeding success on the self-efficacy levels of adolescent mothers during the postpartum period by Veysel Can, Mehmet Bulduk, Emine Kurt Can, Nesrullah Ayşin

“…Conclusions In conclusion, social support networks, including partners, mothers, and mothers-in-law, should be incorporated into breastfeeding training programs to help adolescent mothers leverage these resources effectively. Clinical trial number: Not applicable.…”
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Results of non-interventional observational study of ursodeoxycholic acid in primary biliary cirrhosis by Yelena N. Shirokova, Anna F. Sheptulina

“…Open single center clinical trial included 30 patients with PBC of the I-III stage. …”
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Long-Term Stability of Hydromorphone in Human Plasma Frozen at −20°C for Three Years Quantified by LC-MS/MS by Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov

“…To evaluate the stability of the analgesic opioid hydromorphone, 44 human frozen plasma samples of a former clinical trial were reanalyzed after at least three years. …”
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Mathematical modeling of continuous and intermittent androgen suppression for the treatment of advanced prostate cancer by Alacia M. Voth, John G. Alford, Edward W. Swim

“…We will compute and analyze parameter sensitivity analysis for CAS and IAS which may give insight to plan effective data collection in a future clinical trial. Moreover, a periodic model for IAS is used to develop an analytical formulation for relapse times which then provides information about the sensitivity of relapse to the parameters in our models.…”
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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer by Manish Kohli, Rui Qin, Rafael Jimenez, Scott M. Dehm

“…Specific examples of rational clinical trial designs incorporating potential predictive biomarkers from these pathways will illustrate several aspects of pharmacogenetic and pharmacogenomic predictive biomarker development in advanced prostate cancer therapeutics.…”
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The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome by Huynh Thi Xuan Tam, Luong Nguyen Dac Thuy, Ngo Minh Vinh, Tran Ngoc Anh, Bui Thi Van

“…Materials and Methods. A prospective clinical trial was conducted using metformin and MTX to treat psoriasis patients with metabolic syndrome. …”
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Immunological responses in patients with tuberculosis and in vivo effects of acetyl-L-carnitine oral administration by Emilio Jirillo, Maria Altamura, Carlo Marcuccio, Cosimo Tortorella, Claudio De Simone, Salvatore Antonaci

“…In view of the presence of nonspecific and specific immune deficits in TBC patients, a clinical trial was carried out in a group of 20 individuals with active pulmonary TBC by oral administration of acetyl-L-carnitine (ALC). …”
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Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease by Roger F. Butterworth, Ali Canbay

“…L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. …”
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Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism by Meichen Liu, Kai Li, Yunyun Wang, Guoqing Zhao, Jinlan Jiang

“…In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. …”
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Prediction of individual patient outcomes to psychotherapy vs medication for major depression by Devon LoParo, Boadie W. Dunlop, Charles B. Nemeroff, Helen S. Mayberg, W. Edward Craighead

“…We used machine learning to develop predictor variables that combined demographic and clinical items from a randomized clinical trial. The variables predicted a meaningful proportion of variance in end-of-treatment depression severity for cognitive behavioral therapy (39.7%), escitalopram (32.1%), and duloxetine (67.7%), leading to a high accuracy in predicting remission (71%). …”
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Key tips to shift student perspectives through transformative learning in medical education by Efraim J. Hart, Merel H. de Heer-Koster, Maria van der Harst, Joyce L. Browne, Fedde Scheele

“…The potential impact of these tips on medical education is substantial, as they provide a pathway toward a more responsive, ethical, and sustainable future of healthcare. Clinical trial number: Not applicable.…”
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Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris? by Mina Mirnezami, Hoda Rahimi

“…In this randomized double-blind clinical trial, a total of 118 patients with moderate or severe acne were randomly divided into two (case and control) groups. …”
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Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data by Milena Engelke, Jorge Piano Simões, Laura Basso, Nina Wunder, Berthold Langguth, Thomas Probst, Rüdiger Pryss, Winfried Schlee

“…App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression—Improvement scale (CGI-I). …”
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Error fields: personalized robotic movement training that augments one’s more likely mistakes by Naveed Reza Aghamohammadi, Moria Fisher Bittmann, Verena Klamroth-Marganska, Robert Riener, Felix C. Huang, James L. Patton

“…This study reports results from a clinical trial registered on ClinicalTrials.gov with ID: NCT02720341.…”
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Preoperative uterine artery embolisation before hysterectomy in women with giant uterine fibroid and HIV-associated nephropathy by Filip Szkodziak, Sławomir Woźniak, Łukasz Światłowski, Emilia Maleszyk, Piotr Szkodziak, Krzysztof Pyra, Viktor Berczi, Tomasz Paszkowski, Tomasz Jargiełło

“…Although the benefits of pre-operative UAE before planned myomectomy or hysterectomy in high surgical risk patients with large fibroids has yet to be confirmed in a well-designed clinical trial, this procedure seems to be a promising tool to reduce the risk of perioperative complications in such patients.…”
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Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications by Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi

“…The most relevant in vitro and clinical trial studies were then extracted for final interpretation. …”
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The Effect of an Educational Program Based on Behavioral Intention Model on Childbearing in Women During the Covid 19 Pandemic by Somayeh Seifi, Shahnaz Kohan, Zahra Boroumandfar

“…Materials and Methods: This study was a clinical trial with a pretest–posttest design, conducted on 80 women (control group = 40 and intervention group = 40) in comprehensive health centers in 2019. …”
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