Imagery Rescripting (ImRs) and Eye Movement Desensitization and Reprocessing (EMDR) as treatment of childhood-trauma related post-traumatic stress disorder (Ch-PTSD) in adults: eff... by Martine Daniëls, Marie-Louise Meewisse, Annet Nugter, Sophie A. Rameckers, Eva Fassbinder, Arnoud Arntz

“…Therefore, we evaluated the effects of two treatments for adult patients with Ch-PTSD on Schema Modes.Method: Participants (n = 114) of the Imagery Rescripting and Eye Movement Desensitization and Reprocessing (IREM) Randomized Clinical Trial (Boterhoven de Haan, K. L., Lee, C. W., Fassbinder, E., Voncken, M. …”
Get full text

Association of alcohol abstinence with risk of hyperuricemia in rural Chinese adults: the Henan Rural Cohort Study by Xiaokang Dong, Lulu Zhang, Ning Kang, Huanxiang Zhang, Wei Liao, Xiaotian Liu, Pengling Liu, Lei Yin, Chongjian Wang

“…Moreover, sustained alcohol abstinence could be beneficial for preventing HUA. Clinical Trial Registration The Henan Rural Cohort Study was registered on the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). …”
Get full text

Single-cell RNA sequencing reveals the dysfunctional characteristics of PBMCs in patients with type 2 diabetes mellitus by Jindong Zhao, Jindong Zhao, Jindong Zhao, Zhaohui Fang, Zhaohui Fang, Zhaohui Fang

“…Exploring T2DM biomarkers via single-cell RNA sequencing (scRNA-seq) could provide new insights into the underlying molecular mechanisms.MethodsThe clinical trial registration number is ChiCTR2100049613. …”
Get full text

Number of Patients per Cohort and Sample Size Considerations Using Dose Escalation with Overdose Control by Mourad Tighiouart, André Rogatko

“…The main objective of cancer phase I clinical trials is to determine a maximum tolerated dose (MTD) of a new experimental treatment. …”
Get full text

Antibiotic Prophylaxis in Transarterial Therapy of Hepatocellular Carcinoma: A Meta-Analysis by Jun Wang, Xiao Dong He, You Cheng Zhang

“…Accordingly, this meta-analysis examined clinical trial evidence regarding the effects of prophylactic antibiotic therapy versus no prophylactic treatment with respect to infectious complications in patients undergoing transarterial therapy for HCC.…”
Get full text

Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case by Nevin Alayvaz Aslan, Gülsün Gülten

“…Patients with megakaryoblastic leukemia respond poorly to standard induction regimens and they should be advised to participate in a clinical trial.…”
Get full text

Moderate Hypofractionated Post-Prostatectomy Radiotherapy (MYSTERY) Versus Conventionally Fractionated Post-Prostatectomy Radiotherapy (COPORT) for the Patients With Localized Pros... by Yiyin Liang MD, Weiwei Zhang MD, Xianzhi Zhao MD, Huojun Zhang MD, PhD

“…Methods and analysis This study is a prospective, single-center, open-label, randomized controlled clinical trial. Patients with localized prostate cancer will be randomly allocated to receive COPORT (66-74 Gy at 2 Gy per fraction) or MYSTERY (57.5-65 Gy at 2.5 Gy per fraction). …”
Get full text

Efficacy of Multiple Micronutrients Fortified Milk Consumption on Iron Nutritional Status in Moroccan Schoolchildren by Imane El Menchawy, Asmaa El Hamdouchi, Khalid El Kari, Naima Saeid, Fatima Ezzahra Zahrou, Nada Benajiba, Imane El Harchaoui, Mohamed El Mzibri, Noureddine El Haloui, Hassan Aguenaou

“…The consumption of fortified milk reduced the prevalence of iron deficiency by 27% in schoolchildren living in high altitude rural region of Morocco. Clinical Trial Registration. Our study is registered in the Pan African Clinical Trial Registry with the identification number PACTR201410000896410.…”
Get full text

The effects of diacylglycerol edible oil intervention in patients with chronic metabolic syndrome combined with asymptomatic hyperuricemia: study protocol for a multicenter, prospe... by Gui-yu Li, Cui-feng Zhu, Zhao-qi Huang, Chun-li Piao, Jia-jun Yu, Li Wang, Qiang Zeng, Yu-yu Lei, Yue Li, Xiao-ling Zhu, Zhen-tian Zhang, Tian-hua Huang, Meng-shuang Li, Shu-zhong Lin, Nai-wen Zhang, Fangyingnan Zhang, Yong-hua Wang, Dan-ping Xu

“…Trial registration Chinese Clinical Trial Registry ChiCTR2400085336. Registered on June 5, 2024.…”
Get full text

Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreationally ac... by Dawna Salter, Himana Yalamanchi, Aiswarya Yalamanchi, Amulya Yalamanchi

“…This study suggests that SBS, a novel, standardized extract derived from the gum resin of B. serrata, improves recovery and reduces soreness following high-impact eccentric exercise.Clinical Trial Registrationhttps://ctri.nic.in/Clinicaltrials/pubview2.php, Clinical Trial Registry of India (CTRI/2019/07/020323).…”
Get full text

Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

“…No adverse effects were associated with the use of rFib in the volunteer during the clinical trial.SummaryThe results of this clinical trial indicate that intravenous injections of autologous rFib are both safe and effective for treating SS. …”
Get full text

Inspiratory muscle training facilitates liberation from mechanical ventilation in subacute critically ill patients—a randomized controlled trial by Shu-Jane Wang, Tien-Pei Fang, Tien-Pei Fang, Daniel D. Rowley, Nan-Wei Liu, Jui-O Chen, Jui-Fang Liu, Jui-Fang Liu, Hui-Ling Lin, Hui-Ling Lin, Hui-Ling Lin

“…A moderate correlation between increased creatinine levels and respiratory muscle strength was observed, suggesting that creatinine may be a potential biomarker for muscle recovery during IMT.Clinical trial registrationThis study was registered at ClinicalTrials.gov (NCT06611683).…”
Get full text

A multidisciplinary pain management program for patients with chronic low back pain: a randomized, single-blind, controlled, feasibility study by Anna Dalmau-Roig, Christian Dürsteler, Mirari Ochandorena-Acha, Francisco Vilchez-Oya, Inés Martin-Villalba, Amadeu Obach, Marc Terradas-Monllor

“…Trial registration NCT05974072 (registration date July 11, 2023; retrospectively registered; ClinicalTrials.gov).…”
Get full text

Risk of diabetic ketoacidosis caused by sodium glucose cotransporter-2 inhibitors in patients with type 1 diabetes: a systematic review and network meta-analysis of randomized cont... by Ying Liu, Shiwen Yang, Aidou Jiang, Dan Zou, Zhaoyang Chen, Na Su, Na Su

“…We conducted a network meta-analysis to evaluate the incidence of DKA at different doses in the treatment of T1DM.MethodsWe searched electronic databases and clinical trial registries, including PubMed, Embase (Ovid SP), the Cochrane Central Register of Controlled Trials (Ovid SP), and ClinicalTrials.gov, for randomized controlled trials (RCTs) concerning SGLT2 inhibitors in patients with T1DM from inception to December 2023. …”
Get full text

Effects of Electrical Stimulation on Activation of Mirror Neuron Network in Healthy Adults during Motor Execution and Imitation: An fNIRS Study by Yao Cui, Fang Cong, Fu-Biao Huang, Ming Zeng, Jun Wang

“…Our results revealed that ES has potential to increase activation of most MNN brain areas, providing evidence for related rehabilitative interventions and device development. Clinical Trial Registration: This study was registered on the China Clinical Trial Registration Center (identifier: ChiCTR2200064082, registered 26, September 2022, https://www.chictr.org.cn/showproj.html?…”
Get full text

Nonsurgical Outpatient Therapies for the Management of Female Stress Urinary Incontinence: Long-Term Effectiveness and Durability by G. Willy Davila

“…PubMed was searched for reports on prospective clinical trials with at least 12-month follow-up of minimally invasive treatments, pelvic floor rehabilitation, or pharmacotherapy in women with SUI. …”
Get full text

Current Status of New Anticoagulants in the Management of Venous Thromboembolism by Roberto C. Montoya, Ajeet Gajra

“…The current paper will review the characteristics, clinical trial results, and current and potential therapeutic uses of these new agents with a focus on the categories of direct thrombin inhibitors and activated factor X inhibitors.…”
Get full text

Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects by Yahya H. Dallal Bashi, Rachel Mairs, Rand Murtadha, Vicky Kett

“…This paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. …”
Get full text

Anti‐tumor drug supervision in China from 2010 to 2024: the evolution and prospect of drug review standards by Ling Tang, Yuanyuan Song, Hong Zhang, Ruimin Hao, Xin Tong, Xing Ai, Jun Ma, Zhimin Yang

Get full text

Update on Chemotherapy in the Treatment of Urothelial Carcinoma by Carrie Costantini, Frederick Millard

“…Optimal second-line therapy remains undefined, and targeted agents are under investigation. Clinical trial participation should be encouraged in patients with urothelial carcinoma of the bladder to help improve treatment regimens and outcomes. …”
Get full text